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Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain

Standard

Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain. / Sprenger, Christian; Morris, Laurel S; Koda, Ken; de la Mora, Daniela M; Yamada, Tomomi; Mano, Hiroaki; Kashiwagi, Yuto; Yoshioka, Yoshichika; Morioka, Yasuhide; Seymour, Ben.

in: Brain and neuroscience advances, Jahrgang 2, 2018, S. 2398212818779646.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sprenger, C, Morris, LS, Koda, K, de la Mora, DM, Yamada, T, Mano, H, Kashiwagi, Y, Yoshioka, Y, Morioka, Y & Seymour, B 2018, 'Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain', Brain and neuroscience advances, Jg. 2, S. 2398212818779646. https://doi.org/10.1177/2398212818779646

APA

Sprenger, C., Morris, L. S., Koda, K., de la Mora, D. M., Yamada, T., Mano, H., Kashiwagi, Y., Yoshioka, Y., Morioka, Y., & Seymour, B. (2018). Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain. Brain and neuroscience advances, 2, 2398212818779646. https://doi.org/10.1177/2398212818779646

Vancouver

Sprenger C, Morris LS, Koda K, de la Mora DM, Yamada T, Mano H et al. Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain. Brain and neuroscience advances. 2018;2:2398212818779646. https://doi.org/10.1177/2398212818779646

Bibtex

@article{3f6997aa0fa244c2907f8c6ed901a030,
title = "Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain",
abstract = "A cardinal feature of persistent pain that follows injury is a general suppression of behaviour, in which motivation is inhibited in a way that promotes energy conservation and recuperation. Across species, the anterior cingulate cortex is associated with the motivational aspects of phasic pain, but whether it mediates motivational functions in persistent pain is less clear. Using burrowing behaviour as an marker of non-specific motivated behaviour in rodents, we studied the suppression of burrowing following painful confirmatory factor analysis or control injection into the right knee joint of 30 rats (14 with pain) and examined associated neural connectivity with ultra-high-field resting state functional magnetic resonance imaging. We found that connectivity between anterior cingulate cortex and subcortical structures including hypothalamic/preoptic nuclei and the bed nucleus of the stria terminalis correlated with the reduction in burrowing behaviour observed following the pain manipulation. In summary, the findings implicate anterior cingulate cortex connectivity as a correlate of the motivational aspect of persistent pain in rodents.",
author = "Christian Sprenger and Morris, {Laurel S} and Ken Koda and {de la Mora}, {Daniela M} and Tomomi Yamada and Hiroaki Mano and Yuto Kashiwagi and Yoshichika Yoshioka and Yasuhide Morioka and Ben Seymour",
year = "2018",
doi = "10.1177/2398212818779646",
language = "English",
volume = "2",
pages = "2398212818779646",
journal = "Brain and neuroscience advances",
issn = "2398-2128",
publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain

AU - Sprenger, Christian

AU - Morris, Laurel S

AU - Koda, Ken

AU - de la Mora, Daniela M

AU - Yamada, Tomomi

AU - Mano, Hiroaki

AU - Kashiwagi, Yuto

AU - Yoshioka, Yoshichika

AU - Morioka, Yasuhide

AU - Seymour, Ben

PY - 2018

Y1 - 2018

N2 - A cardinal feature of persistent pain that follows injury is a general suppression of behaviour, in which motivation is inhibited in a way that promotes energy conservation and recuperation. Across species, the anterior cingulate cortex is associated with the motivational aspects of phasic pain, but whether it mediates motivational functions in persistent pain is less clear. Using burrowing behaviour as an marker of non-specific motivated behaviour in rodents, we studied the suppression of burrowing following painful confirmatory factor analysis or control injection into the right knee joint of 30 rats (14 with pain) and examined associated neural connectivity with ultra-high-field resting state functional magnetic resonance imaging. We found that connectivity between anterior cingulate cortex and subcortical structures including hypothalamic/preoptic nuclei and the bed nucleus of the stria terminalis correlated with the reduction in burrowing behaviour observed following the pain manipulation. In summary, the findings implicate anterior cingulate cortex connectivity as a correlate of the motivational aspect of persistent pain in rodents.

AB - A cardinal feature of persistent pain that follows injury is a general suppression of behaviour, in which motivation is inhibited in a way that promotes energy conservation and recuperation. Across species, the anterior cingulate cortex is associated with the motivational aspects of phasic pain, but whether it mediates motivational functions in persistent pain is less clear. Using burrowing behaviour as an marker of non-specific motivated behaviour in rodents, we studied the suppression of burrowing following painful confirmatory factor analysis or control injection into the right knee joint of 30 rats (14 with pain) and examined associated neural connectivity with ultra-high-field resting state functional magnetic resonance imaging. We found that connectivity between anterior cingulate cortex and subcortical structures including hypothalamic/preoptic nuclei and the bed nucleus of the stria terminalis correlated with the reduction in burrowing behaviour observed following the pain manipulation. In summary, the findings implicate anterior cingulate cortex connectivity as a correlate of the motivational aspect of persistent pain in rodents.

U2 - 10.1177/2398212818779646

DO - 10.1177/2398212818779646

M3 - SCORING: Journal article

C2 - 30246156

VL - 2

SP - 2398212818779646

JO - Brain and neuroscience advances

JF - Brain and neuroscience advances

SN - 2398-2128

ER -