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Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application

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Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application. / Sinning, Christoph; Lillpopp, Lars; Appelbaum, Sebastian; Ojeda, Francisco; Zeller, Tanja; Schnabel, Renate; Lubos, Edith; Jagodzinski, Annika; Keller, Till; Munzel, Thomas; Bickel, Christoph; Blankenberg, Stefan.

in: CLIN RES CARDIOL, Jahrgang 102, Nr. 7, 07.2013, S. 495-503.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sinning, C, Lillpopp, L, Appelbaum, S, Ojeda, F, Zeller, T, Schnabel, R, Lubos, E, Jagodzinski, A, Keller, T, Munzel, T, Bickel, C & Blankenberg, S 2013, 'Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application', CLIN RES CARDIOL, Jg. 102, Nr. 7, S. 495-503. https://doi.org/10.1007/s00392-013-0555-4

APA

Sinning, C., Lillpopp, L., Appelbaum, S., Ojeda, F., Zeller, T., Schnabel, R., Lubos, E., Jagodzinski, A., Keller, T., Munzel, T., Bickel, C., & Blankenberg, S. (2013). Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application. CLIN RES CARDIOL, 102(7), 495-503. https://doi.org/10.1007/s00392-013-0555-4

Vancouver

Sinning C, Lillpopp L, Appelbaum S, Ojeda F, Zeller T, Schnabel R et al. Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application. CLIN RES CARDIOL. 2013 Jul;102(7):495-503. https://doi.org/10.1007/s00392-013-0555-4

Bibtex

@article{c777c1a3ac534916bfd2d58c28a54598,
title = "Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application",
abstract = "BACKGROUND: Severity of coronary artery disease (CAD) is related to cardiovascular outcome. We aimed to assess the long-term follow-up depending on Synergy between percutaneous coronary intervention with Taxus and cardiac surgery (SYNTAX) and Gensini score for prognosis. Both scores increase with complexity and thus reflect risk of cardiovascular events.METHODS AND RESULTS: We determined complexity and extent of CAD by the SYNTAX and Gensini score in the AtheroGene cohort (N = 1,974, with 22.6 % women). The endpoint was non-fatal myocardial infarction (N = 132) and cardiovascular death (N = 159) over a median follow-up of 5.4 (Q1: 5.23/Q3: 5.57) years up to 8 years maximum (follow-up rate 99.4%). For SYNTAX score, the following distribution was used: low (≤22, N = 1,404), medium (23-32, N = 314), high score (>32, N = 256). Gensini score was split into thirds. Cox regression analysis showed a hazard ratio (HR) of 1.5 (95% confidence interval 1.16-1.95; p = 0.0024) for the log transformed SYNTAX score in a fully adjusted model and a HR of 1.41 (95% CI 1.13-1.77; p = 0.0025) for the Gensini score. The SYNTAX score alone had a C-index of 0.62, whereas adding clinical variables increased the C-index to 0.67. Similar results were obtained for the Gensini score. Regarding the SYNTAX score using net reclassification index, discrimination of events and non-events was enhanced by 37.2% in a model of clinical variables and biomarkers and by 31.8% for the Gensini score.CONCLUSION: The SYNTAX and Gensini score in combination with clinical variables could be used to predict the cardiovascular prognosis during a long-term follow-up of up to 8 years in CAD patients.",
keywords = "Aged, Cohort Studies, Coronary Angiography/methods, Coronary Artery Disease/physiopathology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction/epidemiology, Percutaneous Coronary Intervention/methods, Prognosis, Proportional Hazards Models, Risk, Risk Factors, Severity of Illness Index, Time Factors",
author = "Christoph Sinning and Lars Lillpopp and Sebastian Appelbaum and Francisco Ojeda and Tanja Zeller and Renate Schnabel and Edith Lubos and Annika Jagodzinski and Till Keller and Thomas Munzel and Christoph Bickel and Stefan Blankenberg",
year = "2013",
month = jul,
doi = "10.1007/s00392-013-0555-4",
language = "English",
volume = "102",
pages = "495--503",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "7",

}

RIS

TY - JOUR

T1 - Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application

AU - Sinning, Christoph

AU - Lillpopp, Lars

AU - Appelbaum, Sebastian

AU - Ojeda, Francisco

AU - Zeller, Tanja

AU - Schnabel, Renate

AU - Lubos, Edith

AU - Jagodzinski, Annika

AU - Keller, Till

AU - Munzel, Thomas

AU - Bickel, Christoph

AU - Blankenberg, Stefan

PY - 2013/7

Y1 - 2013/7

N2 - BACKGROUND: Severity of coronary artery disease (CAD) is related to cardiovascular outcome. We aimed to assess the long-term follow-up depending on Synergy between percutaneous coronary intervention with Taxus and cardiac surgery (SYNTAX) and Gensini score for prognosis. Both scores increase with complexity and thus reflect risk of cardiovascular events.METHODS AND RESULTS: We determined complexity and extent of CAD by the SYNTAX and Gensini score in the AtheroGene cohort (N = 1,974, with 22.6 % women). The endpoint was non-fatal myocardial infarction (N = 132) and cardiovascular death (N = 159) over a median follow-up of 5.4 (Q1: 5.23/Q3: 5.57) years up to 8 years maximum (follow-up rate 99.4%). For SYNTAX score, the following distribution was used: low (≤22, N = 1,404), medium (23-32, N = 314), high score (>32, N = 256). Gensini score was split into thirds. Cox regression analysis showed a hazard ratio (HR) of 1.5 (95% confidence interval 1.16-1.95; p = 0.0024) for the log transformed SYNTAX score in a fully adjusted model and a HR of 1.41 (95% CI 1.13-1.77; p = 0.0025) for the Gensini score. The SYNTAX score alone had a C-index of 0.62, whereas adding clinical variables increased the C-index to 0.67. Similar results were obtained for the Gensini score. Regarding the SYNTAX score using net reclassification index, discrimination of events and non-events was enhanced by 37.2% in a model of clinical variables and biomarkers and by 31.8% for the Gensini score.CONCLUSION: The SYNTAX and Gensini score in combination with clinical variables could be used to predict the cardiovascular prognosis during a long-term follow-up of up to 8 years in CAD patients.

AB - BACKGROUND: Severity of coronary artery disease (CAD) is related to cardiovascular outcome. We aimed to assess the long-term follow-up depending on Synergy between percutaneous coronary intervention with Taxus and cardiac surgery (SYNTAX) and Gensini score for prognosis. Both scores increase with complexity and thus reflect risk of cardiovascular events.METHODS AND RESULTS: We determined complexity and extent of CAD by the SYNTAX and Gensini score in the AtheroGene cohort (N = 1,974, with 22.6 % women). The endpoint was non-fatal myocardial infarction (N = 132) and cardiovascular death (N = 159) over a median follow-up of 5.4 (Q1: 5.23/Q3: 5.57) years up to 8 years maximum (follow-up rate 99.4%). For SYNTAX score, the following distribution was used: low (≤22, N = 1,404), medium (23-32, N = 314), high score (>32, N = 256). Gensini score was split into thirds. Cox regression analysis showed a hazard ratio (HR) of 1.5 (95% confidence interval 1.16-1.95; p = 0.0024) for the log transformed SYNTAX score in a fully adjusted model and a HR of 1.41 (95% CI 1.13-1.77; p = 0.0025) for the Gensini score. The SYNTAX score alone had a C-index of 0.62, whereas adding clinical variables increased the C-index to 0.67. Similar results were obtained for the Gensini score. Regarding the SYNTAX score using net reclassification index, discrimination of events and non-events was enhanced by 37.2% in a model of clinical variables and biomarkers and by 31.8% for the Gensini score.CONCLUSION: The SYNTAX and Gensini score in combination with clinical variables could be used to predict the cardiovascular prognosis during a long-term follow-up of up to 8 years in CAD patients.

KW - Aged

KW - Cohort Studies

KW - Coronary Angiography/methods

KW - Coronary Artery Disease/physiopathology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/epidemiology

KW - Percutaneous Coronary Intervention/methods

KW - Prognosis

KW - Proportional Hazards Models

KW - Risk

KW - Risk Factors

KW - Severity of Illness Index

KW - Time Factors

U2 - 10.1007/s00392-013-0555-4

DO - 10.1007/s00392-013-0555-4

M3 - SCORING: Journal article

C2 - 23519584

VL - 102

SP - 495

EP - 503

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 7

ER -