Anastomotic leak following oesophagectomy: research priorities from an international Delphi consensus study

Oesophago-Gastric Anastomosis Study Group on  the West Midlands Research Collaborative

doi:10.1093/bjs/znaa034

Anastomotic leak following oesophagectomy: research priorities from an international Delphi consensus study

Standard

Anastomotic leak following oesophagectomy: research priorities from an international Delphi consensus study. / Oesophago-Gastric Anastomosis Study Group on the West Midlands Research Collaborative.

in: BRIT J SURG, Jahrgang 108, Nr. 1, 27.01.2021, S. 66-73.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Oesophago-Gastric Anastomosis Study Group on the West Midlands Research Collaborative 2021, 'Anastomotic leak following oesophagectomy: research priorities from an international Delphi consensus study', BRIT J SURG, Jg. 108, Nr. 1, S. 66-73. https://doi.org/10.1093/bjs/znaa034

APA

Oesophago-Gastric Anastomosis Study Group on the West Midlands Research Collaborative (2021). Anastomotic leak following oesophagectomy: research priorities from an international Delphi consensus study. BRIT J SURG, 108(1), 66-73. https://doi.org/10.1093/bjs/znaa034

Vancouver

Oesophago-Gastric Anastomosis Study Group on the West Midlands Research Collaborative. Anastomotic leak following oesophagectomy: research priorities from an international Delphi consensus study. BRIT J SURG. 2021 Jan 27;108(1):66-73. https://doi.org/10.1093/bjs/znaa034

Bibtex

@article{0b00b40390e449b98e1294e326cb78bb,

title = "Anastomotic leak following oesophagectomy: research priorities from an international Delphi consensus study",

abstract = "BACKGROUND: The Oesophago-Gastric Anastomosis Audit (OGAA) is an international collaborative group set up to study anastomotic leak outcomes after oesophagectomy for cancer. This Delphi study aimed to prioritize future research areas of unmet clinical need in RCTs to reduce anastomotic leaks.METHODS: A modified Delphi process was overseen by the OGAA committee, national leads, and engaged clinicians from high-income countries (HICs) and low/middle-income countries (LMICs). A three-stage iterative process was used to prioritize research topics, including a scoping systematic review (stage 1), and two rounds of anonymous electronic voting (stages 2 and 3) addressing research priority and ability to recruit. Stratified analyses were performed by country income.RESULTS: In stage 1, the steering committee proposed research topics across six domains: preoperative optimization, surgical oncology, technical approach, anastomotic technique, enhanced recovery and nutrition, and management of leaks. In stages 2 and stage 3, 192 and 171 respondents respectively participated in online voting. Prioritized research topics include prehabilitation, anastomotic technique, and timing of surgery after neoadjuvant chemo(radio)therapy. Stratified analyses by country income demonstrated no significant differences in research priorities between HICs and LMICs. However, for ability to recruit, there were significant differences between LMICs and HICs for themes related to the technical approach (minimally invasive, width of gastric tube, ischaemic preconditioning) and location of the anastomosis.CONCLUSION: Several areas of research priority are consistent across LMICs and HICs, but discrepancies in ability to recruit by country income will inform future study design.",

keywords = "Anastomotic Leak/etiology, Biomedical Research, Delphi Technique, Esophagectomy/adverse effects, Evidence-Based Medicine, Humans, Research, Surveys and Questionnaires",

author = "{Oesophago-Gastric Anastomosis Study Group on the West Midlands Research Collaborative}",

year = "2021",

month = jan,

day = "27",

doi = "10.1093/bjs/znaa034",

language = "English",

volume = "108",

pages = "66--73",

journal = "BRIT J SURG",

issn = "0007-1323",

publisher = "John Wiley and Sons Ltd",

number = "1",

}

RIS

TY - JOUR

T1 - Anastomotic leak following oesophagectomy: research priorities from an international Delphi consensus study

AU - Oesophago-Gastric Anastomosis Study Group on the West Midlands Research Collaborative

PY - 2021/1/27

Y1 - 2021/1/27

N2 - BACKGROUND: The Oesophago-Gastric Anastomosis Audit (OGAA) is an international collaborative group set up to study anastomotic leak outcomes after oesophagectomy for cancer. This Delphi study aimed to prioritize future research areas of unmet clinical need in RCTs to reduce anastomotic leaks.METHODS: A modified Delphi process was overseen by the OGAA committee, national leads, and engaged clinicians from high-income countries (HICs) and low/middle-income countries (LMICs). A three-stage iterative process was used to prioritize research topics, including a scoping systematic review (stage 1), and two rounds of anonymous electronic voting (stages 2 and 3) addressing research priority and ability to recruit. Stratified analyses were performed by country income.RESULTS: In stage 1, the steering committee proposed research topics across six domains: preoperative optimization, surgical oncology, technical approach, anastomotic technique, enhanced recovery and nutrition, and management of leaks. In stages 2 and stage 3, 192 and 171 respondents respectively participated in online voting. Prioritized research topics include prehabilitation, anastomotic technique, and timing of surgery after neoadjuvant chemo(radio)therapy. Stratified analyses by country income demonstrated no significant differences in research priorities between HICs and LMICs. However, for ability to recruit, there were significant differences between LMICs and HICs for themes related to the technical approach (minimally invasive, width of gastric tube, ischaemic preconditioning) and location of the anastomosis.CONCLUSION: Several areas of research priority are consistent across LMICs and HICs, but discrepancies in ability to recruit by country income will inform future study design.

AB - BACKGROUND: The Oesophago-Gastric Anastomosis Audit (OGAA) is an international collaborative group set up to study anastomotic leak outcomes after oesophagectomy for cancer. This Delphi study aimed to prioritize future research areas of unmet clinical need in RCTs to reduce anastomotic leaks.METHODS: A modified Delphi process was overseen by the OGAA committee, national leads, and engaged clinicians from high-income countries (HICs) and low/middle-income countries (LMICs). A three-stage iterative process was used to prioritize research topics, including a scoping systematic review (stage 1), and two rounds of anonymous electronic voting (stages 2 and 3) addressing research priority and ability to recruit. Stratified analyses were performed by country income.RESULTS: In stage 1, the steering committee proposed research topics across six domains: preoperative optimization, surgical oncology, technical approach, anastomotic technique, enhanced recovery and nutrition, and management of leaks. In stages 2 and stage 3, 192 and 171 respondents respectively participated in online voting. Prioritized research topics include prehabilitation, anastomotic technique, and timing of surgery after neoadjuvant chemo(radio)therapy. Stratified analyses by country income demonstrated no significant differences in research priorities between HICs and LMICs. However, for ability to recruit, there were significant differences between LMICs and HICs for themes related to the technical approach (minimally invasive, width of gastric tube, ischaemic preconditioning) and location of the anastomosis.CONCLUSION: Several areas of research priority are consistent across LMICs and HICs, but discrepancies in ability to recruit by country income will inform future study design.

KW - Anastomotic Leak/etiology

KW - Biomedical Research

KW - Delphi Technique

KW - Esophagectomy/adverse effects

KW - Evidence-Based Medicine

KW - Humans

KW - Research

KW - Surveys and Questionnaires

U2 - 10.1093/bjs/znaa034

DO - 10.1093/bjs/znaa034

M3 - SCORING: Journal article

C2 - 33640931

VL - 108

SP - 66

EP - 73

JO - BRIT J SURG

JF - BRIT J SURG

SN - 0007-1323

IS - 1

ER -