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Analysis of single nucleotide polymorphisms in chronic beryllium disease.

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Analysis of single nucleotide polymorphisms in chronic beryllium disease. / Frye, Björn C; Gaede, Karoline I; Saltini, Cesare; Rossman, Milton D; Monos, Dimitri S; Rosenman, Ken D; Schuler, Christine R; Weston, Ainsley; Wegner, Ralf; Noth, Rainer; Zissel, Gernot; Schreiber, Stefan; Nothnagel, Michael; Müller-Quernheim, Joachim.

in: RESP RES, Jahrgang 22, Nr. 1, 107, 16.04.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › Andere (Vorworte u.ä.) › Forschung

Harvard

Frye, BC, Gaede, KI, Saltini, C, Rossman, MD, Monos, DS, Rosenman, KD, Schuler, CR, Weston, A, Wegner, R, Noth, R, Zissel, G, Schreiber, S, Nothnagel, M & Müller-Quernheim, J 2021, 'Analysis of single nucleotide polymorphisms in chronic beryllium disease.', RESP RES, Jg. 22, Nr. 1, 107. https://doi.org/10.1186/s12931-021-01691-2

APA

Frye, B. C., Gaede, K. I., Saltini, C., Rossman, M. D., Monos, D. S., Rosenman, K. D., Schuler, C. R., Weston, A., Wegner, R., Noth, R., Zissel, G., Schreiber, S., Nothnagel, M., & Müller-Quernheim, J. (2021). Analysis of single nucleotide polymorphisms in chronic beryllium disease. RESP RES, 22(1), [107]. https://doi.org/10.1186/s12931-021-01691-2

Vancouver

Frye BC, Gaede KI, Saltini C, Rossman MD, Monos DS, Rosenman KD et al. Analysis of single nucleotide polymorphisms in chronic beryllium disease. RESP RES. 2021 Apr 16;22(1). 107. https://doi.org/10.1186/s12931-021-01691-2

Bibtex

@article{660a8653e9d14394830307ed61d13284,
title = "Analysis of single nucleotide polymorphisms in chronic beryllium disease.",
abstract = "Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidosis. Even though one of largest cohorts of beryllium-exposed persons was analysed, no statistically relevant association between any SNP and CBD could be verified. Notably, some SNPs exhibit inverse OR for beryllium sensitization and CBD with nominally statistical significance, which allows hypothesizing about pathophysiological role of genes for the disease triggering and development.",
keywords = "Berylliosis/genetics, Beryllium/adverse effects, Butyrophilins/genetics, Chronic Disease, DNA/genetics, Female, Humans, Male, Occupational Exposure/adverse effects, Polymorphism, Single Nucleotide",
author = "Frye, {Bj{\"o}rn C} and Gaede, {Karoline I} and Cesare Saltini and Rossman, {Milton D} and Monos, {Dimitri S} and Rosenman, {Ken D} and Schuler, {Christine R} and Ainsley Weston and Ralf Wegner and Rainer Noth and Gernot Zissel and Stefan Schreiber and Michael Nothnagel and Joachim M{\"u}ller-Quernheim",
year = "2021",
month = apr,
day = "16",
doi = "10.1186/s12931-021-01691-2",
language = "English",
volume = "22",
journal = "RESP RES",
issn = "1465-993X",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Analysis of single nucleotide polymorphisms in chronic beryllium disease.

AU - Frye, Björn C

AU - Gaede, Karoline I

AU - Saltini, Cesare

AU - Rossman, Milton D

AU - Monos, Dimitri S

AU - Rosenman, Ken D

AU - Schuler, Christine R

AU - Weston, Ainsley

AU - Wegner, Ralf

AU - Noth, Rainer

AU - Zissel, Gernot

AU - Schreiber, Stefan

AU - Nothnagel, Michael

AU - Müller-Quernheim, Joachim

PY - 2021/4/16

Y1 - 2021/4/16

N2 - Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidosis. Even though one of largest cohorts of beryllium-exposed persons was analysed, no statistically relevant association between any SNP and CBD could be verified. Notably, some SNPs exhibit inverse OR for beryllium sensitization and CBD with nominally statistical significance, which allows hypothesizing about pathophysiological role of genes for the disease triggering and development.

AB - Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidosis. Even though one of largest cohorts of beryllium-exposed persons was analysed, no statistically relevant association between any SNP and CBD could be verified. Notably, some SNPs exhibit inverse OR for beryllium sensitization and CBD with nominally statistical significance, which allows hypothesizing about pathophysiological role of genes for the disease triggering and development.

KW - Berylliosis/genetics

KW - Beryllium/adverse effects

KW - Butyrophilins/genetics

KW - Chronic Disease

KW - DNA/genetics

KW - Female

KW - Humans

KW - Male

KW - Occupational Exposure/adverse effects

KW - Polymorphism, Single Nucleotide

U2 - 10.1186/s12931-021-01691-2

DO - 10.1186/s12931-021-01691-2

M3 - Other (editorial matter etc.)

C2 - 33863318

VL - 22

JO - RESP RES

JF - RESP RES

SN - 1465-993X

IS - 1

M1 - 107

ER -