Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data.
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Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data. / van der Velden, V H J; Cazzaniga, G; Schrauder, A; Hancock, J; Bader, P; Panzer-Grumayer, E R; Flohr, T; Sutton, R; Cave, H; Madsen, H O; Cayuela, J M; Trka, J; Eckert, C; Foroni, L; Zur Stadt, Udo; Beldjord, K; Raff, T; van der Schoot, C E; van Dongen, J J M.
in: LEUKEMIA, Jahrgang 21, Nr. 4, 4, 2007, S. 604-611.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data.
AU - van der Velden, V H J
AU - Cazzaniga, G
AU - Schrauder, A
AU - Hancock, J
AU - Bader, P
AU - Panzer-Grumayer, E R
AU - Flohr, T
AU - Sutton, R
AU - Cave, H
AU - Madsen, H O
AU - Cayuela, J M
AU - Trka, J
AU - Eckert, C
AU - Foroni, L
AU - Zur Stadt, Udo
AU - Beldjord, K
AU - Raff, T
AU - van der Schoot, C E
AU - van Dongen, J J M
PY - 2007
Y1 - 2007
N2 - Most modern treatment protocols for acute lymphoblastic leukaemia (ALL) include the analysis of minimal residual disease (MRD). To ensure comparable MRD results between different MRD-polymerase chain reaction (PCR) laboratories, standardization and quality control are essential. The European Study Group on MRD detection in ALL (ESG-MRD-ALL), consisting of 30 MRD-PCR laboratories worldwide, has developed guidelines for the interpretation of real-time quantitative PCR-based MRD data. The application of these guidelines ensures identical interpretation of MRD data between different laboratories of the same MRD-based clinical protocol. Furthermore, the ESG-MRD-ALL guidelines will facilitate the comparison of MRD data obtained in different treatment protocols, including those with new drugs.
AB - Most modern treatment protocols for acute lymphoblastic leukaemia (ALL) include the analysis of minimal residual disease (MRD). To ensure comparable MRD results between different MRD-polymerase chain reaction (PCR) laboratories, standardization and quality control are essential. The European Study Group on MRD detection in ALL (ESG-MRD-ALL), consisting of 30 MRD-PCR laboratories worldwide, has developed guidelines for the interpretation of real-time quantitative PCR-based MRD data. The application of these guidelines ensures identical interpretation of MRD data between different laboratories of the same MRD-based clinical protocol. Furthermore, the ESG-MRD-ALL guidelines will facilitate the comparison of MRD data obtained in different treatment protocols, including those with new drugs.
M3 - SCORING: Zeitschriftenaufsatz
VL - 21
SP - 604
EP - 611
JO - LEUKEMIA
JF - LEUKEMIA
SN - 0887-6924
IS - 4
M1 - 4
ER -