Anaemia in cancer patients: pathophysiology, incidence and treatment
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Anaemia in cancer patients: pathophysiology, incidence and treatment. / Bokemeyer, C; Oechsle, K; Hartmann, J-T.
in: EUR J CLIN INVEST, Jahrgang 35 Suppl 3, 12.2005, S. 26-31.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Anaemia in cancer patients: pathophysiology, incidence and treatment
AU - Bokemeyer, C
AU - Oechsle, K
AU - Hartmann, J-T
PY - 2005/12
Y1 - 2005/12
N2 - This review focuses on the pathophysiology, incidence and treatment of anaemia in cancer patients. Causative factors such as different chemotherapy regimens and patient risk factors for the development of anaemia are discussed in order to identify the patient group that is most likely to receive red blood cell transfusions and would thus have the largest benefit from treatment with erythropoietic proteins. The data available with recombinant human erythropoietin alfa, recombinant human erythropoietin beta and darbepoetin alfa are described in more detail and the significant benefit of treating cancer anaemia by these molecules is outlined. Finally, differences in treatment approaches between these erythropoietic proteins are discussed in order to guide treatment decisions specific for the individual patients' situation.
AB - This review focuses on the pathophysiology, incidence and treatment of anaemia in cancer patients. Causative factors such as different chemotherapy regimens and patient risk factors for the development of anaemia are discussed in order to identify the patient group that is most likely to receive red blood cell transfusions and would thus have the largest benefit from treatment with erythropoietic proteins. The data available with recombinant human erythropoietin alfa, recombinant human erythropoietin beta and darbepoetin alfa are described in more detail and the significant benefit of treating cancer anaemia by these molecules is outlined. Finally, differences in treatment approaches between these erythropoietic proteins are discussed in order to guide treatment decisions specific for the individual patients' situation.
KW - Anemia
KW - Antineoplastic Agents
KW - Drug Administration Schedule
KW - Erythropoiesis
KW - Erythropoietin
KW - Hematinics
KW - Humans
KW - Neoplasms
KW - Recombinant Proteins
KW - Treatment Outcome
U2 - 10.1111/j.1365-2362.2005.01527.x
DO - 10.1111/j.1365-2362.2005.01527.x
M3 - SCORING: Journal article
C2 - 16281955
VL - 35 Suppl 3
SP - 26
EP - 31
JO - EUR J CLIN INVEST
JF - EUR J CLIN INVEST
SN - 0014-2972
ER -