An MR-compatible device for automated and safe application of laser stimuli in experiments employing nociceptive stimulation
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An MR-compatible device for automated and safe application of laser stimuli in experiments employing nociceptive stimulation. / Pott, Peter P; Kamping, Sandra; Bomba, Isabelle C; Diesch, Eugen; Flor, Herta; Schwarz, Markus L R.
in: J NEUROSCI METH, Jahrgang 186, Nr. 1, 30.01.2010, S. 1-7.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - An MR-compatible device for automated and safe application of laser stimuli in experiments employing nociceptive stimulation
AU - Pott, Peter P
AU - Kamping, Sandra
AU - Bomba, Isabelle C
AU - Diesch, Eugen
AU - Flor, Herta
AU - Schwarz, Markus L R
N1 - (c) 2009 Elsevier B.V. All rights reserved.
PY - 2010/1/30
Y1 - 2010/1/30
N2 - In this paper the establishment of an automatic laser application device that reproducibly delivers laser stimuli in a safe, controlled, and reliable manner is presented. Nociceptive stimulation is widely used in functional magnetic resonance imaging (fMRI) experiments and a number of different methods are employed. One major advantage of laser stimulation as a method to administer painful stimuli is that it selectively activates nociceptors. To avoid damage to the subject's skin, which might occur if the same skin area were stimulated too often, the laser focal spot needs to be repositioned after each stimulus. Here, we describe the design of the mechanical set-up, the functionality, the computation of laser stimulus intensity, the materials used, the monitoring system, and the interface to the control software. Additionally, MR-compatibility and functionality of the device were evaluated and assessed in a 3T MR scanner. Finally, the reliability and validity of the device were tested and demonstrated. It permits easy and investigator-independent use of laser stimulation in the MR scanner.
AB - In this paper the establishment of an automatic laser application device that reproducibly delivers laser stimuli in a safe, controlled, and reliable manner is presented. Nociceptive stimulation is widely used in functional magnetic resonance imaging (fMRI) experiments and a number of different methods are employed. One major advantage of laser stimulation as a method to administer painful stimuli is that it selectively activates nociceptors. To avoid damage to the subject's skin, which might occur if the same skin area were stimulated too often, the laser focal spot needs to be repositioned after each stimulus. Here, we describe the design of the mechanical set-up, the functionality, the computation of laser stimulus intensity, the materials used, the monitoring system, and the interface to the control software. Additionally, MR-compatibility and functionality of the device were evaluated and assessed in a 3T MR scanner. Finally, the reliability and validity of the device were tested and demonstrated. It permits easy and investigator-independent use of laser stimulation in the MR scanner.
KW - Adult
KW - Afferent Pathways
KW - Automation
KW - Brain
KW - Brain Mapping
KW - Computers
KW - Female
KW - Functional Laterality
KW - Hot Temperature
KW - Humans
KW - Lasers
KW - Magnetic Resonance Imaging
KW - Male
KW - Nociceptors
KW - Pain
KW - Pain Measurement
KW - Physical Stimulation
KW - Sensory Receptor Cells
KW - Skin
KW - Software
KW - User-Computer Interface
KW - Young Adult
U2 - 10.1016/j.jneumeth.2009.10.014
DO - 10.1016/j.jneumeth.2009.10.014
M3 - SCORING: Journal article
C2 - 19854215
VL - 186
SP - 1
EP - 7
JO - J NEUROSCI METH
JF - J NEUROSCI METH
SN - 0165-0270
IS - 1
ER -
