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An atypical role for the myeloid receptor Mincle in central nervous system injury

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An atypical role for the myeloid receptor Mincle in central nervous system injury. / Arumugam, Thiruma V; Manzanero, Silvia; Furtado, Milena; Biggins, Patrick J; Hsieh, Yu-Hsuan; Gelderblom, Mathias; MacDonald, Kelli Pa; Salimova, Ekaterina; Li, Yu-I; Korn, Othmar; Dewar, Deborah; Macrae, I Mhairi; Ashman, Robert B; Tang, Sung-Chun; Rosenthal, Nadia A; Ruitenberg, Marc J; Magnus, Tim; Wells, Christine A.

in: J CEREBR BLOOD F MET, Jahrgang 37, Nr. 6, 06.2017, S. 2098-2111.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Arumugam, TV, Manzanero, S, Furtado, M, Biggins, PJ, Hsieh, Y-H, Gelderblom, M, MacDonald, KP, Salimova, E, Li, Y-I, Korn, O, Dewar, D, Macrae, IM, Ashman, RB, Tang, S-C, Rosenthal, NA, Ruitenberg, MJ, Magnus, T & Wells, CA 2017, 'An atypical role for the myeloid receptor Mincle in central nervous system injury', J CEREBR BLOOD F MET, Jg. 37, Nr. 6, S. 2098-2111. https://doi.org/10.1177/0271678X16661201

APA

Arumugam, T. V., Manzanero, S., Furtado, M., Biggins, P. J., Hsieh, Y-H., Gelderblom, M., MacDonald, K. P., Salimova, E., Li, Y-I., Korn, O., Dewar, D., Macrae, I. M., Ashman, R. B., Tang, S-C., Rosenthal, N. A., Ruitenberg, M. J., Magnus, T., & Wells, C. A. (2017). An atypical role for the myeloid receptor Mincle in central nervous system injury. J CEREBR BLOOD F MET, 37(6), 2098-2111. https://doi.org/10.1177/0271678X16661201

Vancouver

Arumugam TV, Manzanero S, Furtado M, Biggins PJ, Hsieh Y-H, Gelderblom M et al. An atypical role for the myeloid receptor Mincle in central nervous system injury. J CEREBR BLOOD F MET. 2017 Jun;37(6):2098-2111. https://doi.org/10.1177/0271678X16661201

Bibtex

@article{1f147c00d5a740489ebeb507ac440074,
title = "An atypical role for the myeloid receptor Mincle in central nervous system injury",
abstract = "The C-type lectin Mincle is implicated in innate immune responses to sterile inflammation, but its contribution to associated pathologies is not well understood. Herein, we show that Mincle exacerbates neuronal loss following ischemic but not traumatic spinal cord injury. Loss of Mincle was beneficial in a model of transient middle cerebral artery occlusion but did not alter outcomes following heart or gut ischemia. High functional scores in Mincle KO animals using the focal cerebral ischemia model were accompanied by reduced lesion size, fewer infiltrating leukocytes and less neutrophil-derived cytokine production than isogenic controls. Bone marrow chimera experiments revealed that the presence of Mincle in the central nervous system, rather than recruited immune cells, was the critical regulator of a poor outcome following transient middle cerebral artery occlusion. There was no evidence for a direct role for Mincle in microglia or neural activation, but expression in a subset of macrophages resident in the perivascular niche provided new clues on Mincle's role in ischemic stroke.",
author = "Arumugam, {Thiruma V} and Silvia Manzanero and Milena Furtado and Biggins, {Patrick J} and Yu-Hsuan Hsieh and Mathias Gelderblom and MacDonald, {Kelli Pa} and Ekaterina Salimova and Yu-I Li and Othmar Korn and Deborah Dewar and Macrae, {I Mhairi} and Ashman, {Robert B} and Sung-Chun Tang and Rosenthal, {Nadia A} and Ruitenberg, {Marc J} and Tim Magnus and Wells, {Christine A}",
note = "{\textcopyright} The Author(s) 2016.",
year = "2017",
month = jun,
doi = "10.1177/0271678X16661201",
language = "English",
volume = "37",
pages = "2098--2111",
journal = "J CEREBR BLOOD F MET",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "6",

}

RIS

TY - JOUR

T1 - An atypical role for the myeloid receptor Mincle in central nervous system injury

AU - Arumugam, Thiruma V

AU - Manzanero, Silvia

AU - Furtado, Milena

AU - Biggins, Patrick J

AU - Hsieh, Yu-Hsuan

AU - Gelderblom, Mathias

AU - MacDonald, Kelli Pa

AU - Salimova, Ekaterina

AU - Li, Yu-I

AU - Korn, Othmar

AU - Dewar, Deborah

AU - Macrae, I Mhairi

AU - Ashman, Robert B

AU - Tang, Sung-Chun

AU - Rosenthal, Nadia A

AU - Ruitenberg, Marc J

AU - Magnus, Tim

AU - Wells, Christine A

N1 - © The Author(s) 2016.

PY - 2017/6

Y1 - 2017/6

N2 - The C-type lectin Mincle is implicated in innate immune responses to sterile inflammation, but its contribution to associated pathologies is not well understood. Herein, we show that Mincle exacerbates neuronal loss following ischemic but not traumatic spinal cord injury. Loss of Mincle was beneficial in a model of transient middle cerebral artery occlusion but did not alter outcomes following heart or gut ischemia. High functional scores in Mincle KO animals using the focal cerebral ischemia model were accompanied by reduced lesion size, fewer infiltrating leukocytes and less neutrophil-derived cytokine production than isogenic controls. Bone marrow chimera experiments revealed that the presence of Mincle in the central nervous system, rather than recruited immune cells, was the critical regulator of a poor outcome following transient middle cerebral artery occlusion. There was no evidence for a direct role for Mincle in microglia or neural activation, but expression in a subset of macrophages resident in the perivascular niche provided new clues on Mincle's role in ischemic stroke.

AB - The C-type lectin Mincle is implicated in innate immune responses to sterile inflammation, but its contribution to associated pathologies is not well understood. Herein, we show that Mincle exacerbates neuronal loss following ischemic but not traumatic spinal cord injury. Loss of Mincle was beneficial in a model of transient middle cerebral artery occlusion but did not alter outcomes following heart or gut ischemia. High functional scores in Mincle KO animals using the focal cerebral ischemia model were accompanied by reduced lesion size, fewer infiltrating leukocytes and less neutrophil-derived cytokine production than isogenic controls. Bone marrow chimera experiments revealed that the presence of Mincle in the central nervous system, rather than recruited immune cells, was the critical regulator of a poor outcome following transient middle cerebral artery occlusion. There was no evidence for a direct role for Mincle in microglia or neural activation, but expression in a subset of macrophages resident in the perivascular niche provided new clues on Mincle's role in ischemic stroke.

U2 - 10.1177/0271678X16661201

DO - 10.1177/0271678X16661201

M3 - SCORING: Journal article

C2 - 27492949

VL - 37

SP - 2098

EP - 2111

JO - J CEREBR BLOOD F MET

JF - J CEREBR BLOOD F MET

SN - 0271-678X

IS - 6

ER -