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An A/C germline single-nucleotide polymorphism in the TNFAIP3 gene is associated with advanced disease stage and survival in only surgically treated esophageal cancer

Standard

An A/C germline single-nucleotide polymorphism in the TNFAIP3 gene is associated with advanced disease stage and survival in only surgically treated esophageal cancer. / Ghadban, Tarik; Schmidt-Yang, Magdalena; Uzunoglu, Faik G; Perez, Daniel R; Tsui, Tung Y; El Gammal, Alexander T; Erbes, Peter J; Zilbermints, Veacheslav; Wellner, Ulrich; Pantel, Klaus; Izbicki, Jakob R; Vashist, Yogesh K.

in: J HUM GENET, Jahrgang 59, Nr. 12, 2014, S. 661-666.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ghadban, T, Schmidt-Yang, M, Uzunoglu, FG, Perez, DR, Tsui, TY, El Gammal, AT, Erbes, PJ, Zilbermints, V, Wellner, U, Pantel, K, Izbicki, JR & Vashist, YK 2014, 'An A/C germline single-nucleotide polymorphism in the TNFAIP3 gene is associated with advanced disease stage and survival in only surgically treated esophageal cancer', J HUM GENET, Jg. 59, Nr. 12, S. 661-666. https://doi.org/10.1038/jhg.2014.90

APA

Ghadban, T., Schmidt-Yang, M., Uzunoglu, F. G., Perez, D. R., Tsui, T. Y., El Gammal, A. T., Erbes, P. J., Zilbermints, V., Wellner, U., Pantel, K., Izbicki, J. R., & Vashist, Y. K. (2014). An A/C germline single-nucleotide polymorphism in the TNFAIP3 gene is associated with advanced disease stage and survival in only surgically treated esophageal cancer. J HUM GENET, 59(12), 661-666. https://doi.org/10.1038/jhg.2014.90

Vancouver

Ghadban T, Schmidt-Yang M, Uzunoglu FG, Perez DR, Tsui TY, El Gammal AT et al. An A/C germline single-nucleotide polymorphism in the TNFAIP3 gene is associated with advanced disease stage and survival in only surgically treated esophageal cancer. J HUM GENET. 2014;59(12):661-666. https://doi.org/10.1038/jhg.2014.90

Bibtex

@article{27c07279704343d28f240c624c9b2904,
title = "An A/C germline single-nucleotide polymorphism in the TNFAIP3 gene is associated with advanced disease stage and survival in only surgically treated esophageal cancer",
abstract = "Prognostication of disease relapse and survival is essential for cancer patients and genetic variations in cancer patients may serve as important indicators. A single-nucleotide polymorphism (SNP) mapping to the tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) gene at position 138241110 displays three genotypes (AA, AC and CC). The aim of this study was to evaluate the potential prognostic value of the TNFAIP3-SNP in esophageal cancer (EC). Genomic DNA was extracted from peripheral blood leukocytes of 173 patients who underwent complete surgical resection for EC and did not receive any neoadjuvant or adjuvant therapy. For SNP detection, a 260- bp fragment was PCR amplified, purified and sequenced with tested primers. The product was analyzed by automatic DNA sequencer.The TNFAIP3 genotypes were correlated with clinico-pathological parameters, tumor cell dissemination in bone marrow and clinical outcome. The C-allele carrier presented with higher disease stage (P<0.001). This was predominantly because of the presence of lymph node metastasis (P<0.001). The recurrence rate was higher in C-allele carriers (AC and CC genotype; P=0.004). Kaplan-Meier plots for disease-free (P=0.017) and overall survival (P<0.001) displayed a gene dosage-associated outcome with AA genotype patients presenting the longest and CC genotype patients the poorest survival. In disease stage-adjusted multivariate analysis the TNFAIP3-SNP was identified as an independent prognostic factor for survival (hazard ratio 1.9; P=0.008). The TNFAIP3-SNP allows risk stratification of EC patients and may be a useful tool to identify patients eligible for multimodal therapy concepts.Journal of Human Genetics advance online publication, 30 October 2014; doi:10.1038/jhg.2014.90.",
author = "Tarik Ghadban and Magdalena Schmidt-Yang and Uzunoglu, {Faik G} and Perez, {Daniel R} and Tsui, {Tung Y} and {El Gammal}, {Alexander T} and Erbes, {Peter J} and Veacheslav Zilbermints and Ulrich Wellner and Klaus Pantel and Izbicki, {Jakob R} and Vashist, {Yogesh K}",
year = "2014",
doi = "10.1038/jhg.2014.90",
language = "English",
volume = "59",
pages = "661--666",
journal = "J HUM GENET",
issn = "1434-5161",
publisher = "NATURE PUBLISHING GROUP",
number = "12",

}

RIS

TY - JOUR

T1 - An A/C germline single-nucleotide polymorphism in the TNFAIP3 gene is associated with advanced disease stage and survival in only surgically treated esophageal cancer

AU - Ghadban, Tarik

AU - Schmidt-Yang, Magdalena

AU - Uzunoglu, Faik G

AU - Perez, Daniel R

AU - Tsui, Tung Y

AU - El Gammal, Alexander T

AU - Erbes, Peter J

AU - Zilbermints, Veacheslav

AU - Wellner, Ulrich

AU - Pantel, Klaus

AU - Izbicki, Jakob R

AU - Vashist, Yogesh K

PY - 2014

Y1 - 2014

N2 - Prognostication of disease relapse and survival is essential for cancer patients and genetic variations in cancer patients may serve as important indicators. A single-nucleotide polymorphism (SNP) mapping to the tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) gene at position 138241110 displays three genotypes (AA, AC and CC). The aim of this study was to evaluate the potential prognostic value of the TNFAIP3-SNP in esophageal cancer (EC). Genomic DNA was extracted from peripheral blood leukocytes of 173 patients who underwent complete surgical resection for EC and did not receive any neoadjuvant or adjuvant therapy. For SNP detection, a 260- bp fragment was PCR amplified, purified and sequenced with tested primers. The product was analyzed by automatic DNA sequencer.The TNFAIP3 genotypes were correlated with clinico-pathological parameters, tumor cell dissemination in bone marrow and clinical outcome. The C-allele carrier presented with higher disease stage (P<0.001). This was predominantly because of the presence of lymph node metastasis (P<0.001). The recurrence rate was higher in C-allele carriers (AC and CC genotype; P=0.004). Kaplan-Meier plots for disease-free (P=0.017) and overall survival (P<0.001) displayed a gene dosage-associated outcome with AA genotype patients presenting the longest and CC genotype patients the poorest survival. In disease stage-adjusted multivariate analysis the TNFAIP3-SNP was identified as an independent prognostic factor for survival (hazard ratio 1.9; P=0.008). The TNFAIP3-SNP allows risk stratification of EC patients and may be a useful tool to identify patients eligible for multimodal therapy concepts.Journal of Human Genetics advance online publication, 30 October 2014; doi:10.1038/jhg.2014.90.

AB - Prognostication of disease relapse and survival is essential for cancer patients and genetic variations in cancer patients may serve as important indicators. A single-nucleotide polymorphism (SNP) mapping to the tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) gene at position 138241110 displays three genotypes (AA, AC and CC). The aim of this study was to evaluate the potential prognostic value of the TNFAIP3-SNP in esophageal cancer (EC). Genomic DNA was extracted from peripheral blood leukocytes of 173 patients who underwent complete surgical resection for EC and did not receive any neoadjuvant or adjuvant therapy. For SNP detection, a 260- bp fragment was PCR amplified, purified and sequenced with tested primers. The product was analyzed by automatic DNA sequencer.The TNFAIP3 genotypes were correlated with clinico-pathological parameters, tumor cell dissemination in bone marrow and clinical outcome. The C-allele carrier presented with higher disease stage (P<0.001). This was predominantly because of the presence of lymph node metastasis (P<0.001). The recurrence rate was higher in C-allele carriers (AC and CC genotype; P=0.004). Kaplan-Meier plots for disease-free (P=0.017) and overall survival (P<0.001) displayed a gene dosage-associated outcome with AA genotype patients presenting the longest and CC genotype patients the poorest survival. In disease stage-adjusted multivariate analysis the TNFAIP3-SNP was identified as an independent prognostic factor for survival (hazard ratio 1.9; P=0.008). The TNFAIP3-SNP allows risk stratification of EC patients and may be a useful tool to identify patients eligible for multimodal therapy concepts.Journal of Human Genetics advance online publication, 30 October 2014; doi:10.1038/jhg.2014.90.

U2 - 10.1038/jhg.2014.90

DO - 10.1038/jhg.2014.90

M3 - SCORING: Journal article

C2 - 25354935

VL - 59

SP - 661

EP - 666

JO - J HUM GENET

JF - J HUM GENET

SN - 1434-5161

IS - 12

ER -