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Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer.

Standard

Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer. / Simon, Ronald; Struckmann, Kirsten; Schraml, Peter; Wagner, Urs; Forster, Thomas; Moch, Holger; Fijan, André; Bruderer, James; Wilber, Kim; Mihatsch, Michael J; Gasser, Thomas; Sauter, Guido.

in: ONCOGENE, Jahrgang 21, Nr. 16, 16, 2002, S. 2476-2483.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Simon, R, Struckmann, K, Schraml, P, Wagner, U, Forster, T, Moch, H, Fijan, A, Bruderer, J, Wilber, K, Mihatsch, MJ, Gasser, T & Sauter, G 2002, 'Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer.', ONCOGENE, Jg. 21, Nr. 16, 16, S. 2476-2483. <http://www.ncbi.nlm.nih.gov/pubmed/11971182?dopt=Citation>

APA

Simon, R., Struckmann, K., Schraml, P., Wagner, U., Forster, T., Moch, H., Fijan, A., Bruderer, J., Wilber, K., Mihatsch, M. J., Gasser, T., & Sauter, G. (2002). Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer. ONCOGENE, 21(16), 2476-2483. [16]. http://www.ncbi.nlm.nih.gov/pubmed/11971182?dopt=Citation

Vancouver

Simon R, Struckmann K, Schraml P, Wagner U, Forster T, Moch H et al. Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer. ONCOGENE. 2002;21(16):2476-2483. 16.

Bibtex

@article{f67f5a9d616e44e0971d306b3c1f44e9,
title = "Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer.",
abstract = "The chromosomal region 12q13-q15 is recurrently amplified in bladder cancer. Putative target genes located in this region include MDM2, CDK4, and GLI. To evaluate the involvement of these genes in bladder cancer, we screened a tissue microarray (TMA) containing 2317 samples by fluorescence in situ hybridization (FISH). Amplification was found for MDM2 in 5.1%, for CDK4 in 1.1%, and for GLI in 0.4% of interpretable tumors. Among tumors having amplification of at least one of these 12q13-q15 genes, 76.6% had amplification of MDM2 alone and 6.4% had amplification of CDK4 alone. Coamplifications were seen of MDM2 and CDK4 in 10.6%, and of CDK4 and GLI in 6.4%. Neither coamplifications of all three genes nor isolated GLI amplifications were found. These data suggest a prominent role of MDM2 as a 12q13-q15 amplification target in bladder cancer. However, independent CDK4 amplifications do also occur suggesting either two non-overlapping amplification sites or else a minimal overlapping region between MDM2 and CDK4 perhaps containing another yet unknown oncogene. The frequency of amplification increased significantly from stage pTa to pT1-4 (P",
author = "Ronald Simon and Kirsten Struckmann and Peter Schraml and Urs Wagner and Thomas Forster and Holger Moch and Andr{\'e} Fijan and James Bruderer and Kim Wilber and Mihatsch, {Michael J} and Thomas Gasser and Guido Sauter",
year = "2002",
language = "Deutsch",
volume = "21",
pages = "2476--2483",
journal = "ONCOGENE",
issn = "0950-9232",
publisher = "NATURE PUBLISHING GROUP",
number = "16",

}

RIS

TY - JOUR

T1 - Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer.

AU - Simon, Ronald

AU - Struckmann, Kirsten

AU - Schraml, Peter

AU - Wagner, Urs

AU - Forster, Thomas

AU - Moch, Holger

AU - Fijan, André

AU - Bruderer, James

AU - Wilber, Kim

AU - Mihatsch, Michael J

AU - Gasser, Thomas

AU - Sauter, Guido

PY - 2002

Y1 - 2002

N2 - The chromosomal region 12q13-q15 is recurrently amplified in bladder cancer. Putative target genes located in this region include MDM2, CDK4, and GLI. To evaluate the involvement of these genes in bladder cancer, we screened a tissue microarray (TMA) containing 2317 samples by fluorescence in situ hybridization (FISH). Amplification was found for MDM2 in 5.1%, for CDK4 in 1.1%, and for GLI in 0.4% of interpretable tumors. Among tumors having amplification of at least one of these 12q13-q15 genes, 76.6% had amplification of MDM2 alone and 6.4% had amplification of CDK4 alone. Coamplifications were seen of MDM2 and CDK4 in 10.6%, and of CDK4 and GLI in 6.4%. Neither coamplifications of all three genes nor isolated GLI amplifications were found. These data suggest a prominent role of MDM2 as a 12q13-q15 amplification target in bladder cancer. However, independent CDK4 amplifications do also occur suggesting either two non-overlapping amplification sites or else a minimal overlapping region between MDM2 and CDK4 perhaps containing another yet unknown oncogene. The frequency of amplification increased significantly from stage pTa to pT1-4 (P

AB - The chromosomal region 12q13-q15 is recurrently amplified in bladder cancer. Putative target genes located in this region include MDM2, CDK4, and GLI. To evaluate the involvement of these genes in bladder cancer, we screened a tissue microarray (TMA) containing 2317 samples by fluorescence in situ hybridization (FISH). Amplification was found for MDM2 in 5.1%, for CDK4 in 1.1%, and for GLI in 0.4% of interpretable tumors. Among tumors having amplification of at least one of these 12q13-q15 genes, 76.6% had amplification of MDM2 alone and 6.4% had amplification of CDK4 alone. Coamplifications were seen of MDM2 and CDK4 in 10.6%, and of CDK4 and GLI in 6.4%. Neither coamplifications of all three genes nor isolated GLI amplifications were found. These data suggest a prominent role of MDM2 as a 12q13-q15 amplification target in bladder cancer. However, independent CDK4 amplifications do also occur suggesting either two non-overlapping amplification sites or else a minimal overlapping region between MDM2 and CDK4 perhaps containing another yet unknown oncogene. The frequency of amplification increased significantly from stage pTa to pT1-4 (P

M3 - SCORING: Zeitschriftenaufsatz

VL - 21

SP - 2476

EP - 2483

JO - ONCOGENE

JF - ONCOGENE

SN - 0950-9232

IS - 16

M1 - 16

ER -