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Aminopeptidase A is a functional target in angiogenic blood vessels

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Aminopeptidase A is a functional target in angiogenic blood vessels. / Marchiò, Serena; Lahdenranta, Johanna; Schlingemann, Reinier O; Valdembri, Donatella; Wesseling, Pieter; Arap, Marco A; Hajitou, Amin; Ozawa, Michael G; Trepel, Martin; Giordano, Ricardo J; Nanus, David M; Dijkman, Henri B P M; Oosterwijk, Egbert; Sidman, Richard L; Cooper, Max D; Bussolino, Federico; Pasqualini, Renata; Arap, Wadih.

in: CANCER CELL, Jahrgang 5, Nr. 2, 02.2004, S. 151-62.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Marchiò, S, Lahdenranta, J, Schlingemann, RO, Valdembri, D, Wesseling, P, Arap, MA, Hajitou, A, Ozawa, MG, Trepel, M, Giordano, RJ, Nanus, DM, Dijkman, HBPM, Oosterwijk, E, Sidman, RL, Cooper, MD, Bussolino, F, Pasqualini, R & Arap, W 2004, 'Aminopeptidase A is a functional target in angiogenic blood vessels', CANCER CELL, Jg. 5, Nr. 2, S. 151-62.

APA

Marchiò, S., Lahdenranta, J., Schlingemann, R. O., Valdembri, D., Wesseling, P., Arap, M. A., Hajitou, A., Ozawa, M. G., Trepel, M., Giordano, R. J., Nanus, D. M., Dijkman, H. B. P. M., Oosterwijk, E., Sidman, R. L., Cooper, M. D., Bussolino, F., Pasqualini, R., & Arap, W. (2004). Aminopeptidase A is a functional target in angiogenic blood vessels. CANCER CELL, 5(2), 151-62.

Vancouver

Marchiò S, Lahdenranta J, Schlingemann RO, Valdembri D, Wesseling P, Arap MA et al. Aminopeptidase A is a functional target in angiogenic blood vessels. CANCER CELL. 2004 Feb;5(2):151-62.

Bibtex

@article{72c8b252e5e842ada99c7cb83e9f76bc,
title = "Aminopeptidase A is a functional target in angiogenic blood vessels",
abstract = "We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors. To gain mechanistic insight, we evaluated angiogenesis in APA null mice. We found that, although these mice develop normally, they fail to mount the expected angiogenic response to hypoxia or growth factors. We then isolated peptide inhibitors of APA from a peptide library and show that they specifically bind to and inhibit APA, suppress migration and proliferation of endothelial cells, inhibit angiogenesis, and home to tumor blood vessels. Finally, we successfully treated tumor-bearing mice with APA binding peptides or anti-APA blocking monoclonal antibodies. These data show that APA is a regulator of blood vessel formation, and can serve as a functional vascular target.",
keywords = "Amino Acid Motifs, Animals, Blood Vessels, Cell Division, Cell Hypoxia, Cell Movement, Chick Embryo, Endothelial Cells, Enzyme Inhibitors, Glutamyl Aminopeptidase, Growth Substances, Humans, Mice, Mice, Knockout, Microscopy, Fluorescence, Neoplasms, Neovascularization, Pathologic, Peptide Library, Peptides, Protein Binding, Transplantation, Heterologous, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.",
author = "Serena Marchi{\`o} and Johanna Lahdenranta and Schlingemann, {Reinier O} and Donatella Valdembri and Pieter Wesseling and Arap, {Marco A} and Amin Hajitou and Ozawa, {Michael G} and Martin Trepel and Giordano, {Ricardo J} and Nanus, {David M} and Dijkman, {Henri B P M} and Egbert Oosterwijk and Sidman, {Richard L} and Cooper, {Max D} and Federico Bussolino and Renata Pasqualini and Wadih Arap",
year = "2004",
month = feb,
language = "English",
volume = "5",
pages = "151--62",
journal = "CANCER CELL",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - Aminopeptidase A is a functional target in angiogenic blood vessels

AU - Marchiò, Serena

AU - Lahdenranta, Johanna

AU - Schlingemann, Reinier O

AU - Valdembri, Donatella

AU - Wesseling, Pieter

AU - Arap, Marco A

AU - Hajitou, Amin

AU - Ozawa, Michael G

AU - Trepel, Martin

AU - Giordano, Ricardo J

AU - Nanus, David M

AU - Dijkman, Henri B P M

AU - Oosterwijk, Egbert

AU - Sidman, Richard L

AU - Cooper, Max D

AU - Bussolino, Federico

AU - Pasqualini, Renata

AU - Arap, Wadih

PY - 2004/2

Y1 - 2004/2

N2 - We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors. To gain mechanistic insight, we evaluated angiogenesis in APA null mice. We found that, although these mice develop normally, they fail to mount the expected angiogenic response to hypoxia or growth factors. We then isolated peptide inhibitors of APA from a peptide library and show that they specifically bind to and inhibit APA, suppress migration and proliferation of endothelial cells, inhibit angiogenesis, and home to tumor blood vessels. Finally, we successfully treated tumor-bearing mice with APA binding peptides or anti-APA blocking monoclonal antibodies. These data show that APA is a regulator of blood vessel formation, and can serve as a functional vascular target.

AB - We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors. To gain mechanistic insight, we evaluated angiogenesis in APA null mice. We found that, although these mice develop normally, they fail to mount the expected angiogenic response to hypoxia or growth factors. We then isolated peptide inhibitors of APA from a peptide library and show that they specifically bind to and inhibit APA, suppress migration and proliferation of endothelial cells, inhibit angiogenesis, and home to tumor blood vessels. Finally, we successfully treated tumor-bearing mice with APA binding peptides or anti-APA blocking monoclonal antibodies. These data show that APA is a regulator of blood vessel formation, and can serve as a functional vascular target.

KW - Amino Acid Motifs

KW - Animals

KW - Blood Vessels

KW - Cell Division

KW - Cell Hypoxia

KW - Cell Movement

KW - Chick Embryo

KW - Endothelial Cells

KW - Enzyme Inhibitors

KW - Glutamyl Aminopeptidase

KW - Growth Substances

KW - Humans

KW - Mice

KW - Mice, Knockout

KW - Microscopy, Fluorescence

KW - Neoplasms

KW - Neovascularization, Pathologic

KW - Peptide Library

KW - Peptides

KW - Protein Binding

KW - Transplantation, Heterologous

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, P.H.S.

M3 - SCORING: Journal article

C2 - 14998491

VL - 5

SP - 151

EP - 162

JO - CANCER CELL

JF - CANCER CELL

SN - 1535-6108

IS - 2

ER -