PortalPublikationenAlternative cross-priming through CCL17-CCR4-mediated attrac...

Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.

Standard

Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. / Semmling, Verena; Lukacs-Kornek, Veronika; Thaiss, Christoph A; Quast, Thomas; Hochheiser, Katharina; Panzer, Ulf; Rossjohn, Jamie; Perlmutter, Patrick; Cao, Jia; Godfrey, Dale I; Savage, Paul B; Knolle, Percy A; Kolanus, Waldemar; Förster, Irmgard; Kurts, Christian.

in: NAT IMMUNOL, Jahrgang 11, Nr. 4, 4, 2010, S. 313-320.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Semmling, V, Lukacs-Kornek, V, Thaiss, CA, Quast, T, Hochheiser, K, Panzer, U, Rossjohn, J, Perlmutter, P, Cao, J, Godfrey, DI, Savage, PB, Knolle, PA, Kolanus, W, Förster, I & Kurts, C 2010, 'Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.', NAT IMMUNOL, Jg. 11, Nr. 4, 4, S. 313-320. <http://www.ncbi.nlm.nih.gov/pubmed/20190758?dopt=Citation>

APA

Semmling, V., Lukacs-Kornek, V., Thaiss, C. A., Quast, T., Hochheiser, K., Panzer, U., Rossjohn, J., Perlmutter, P., Cao, J., Godfrey, D. I., Savage, P. B., Knolle, P. A., Kolanus, W., Förster, I., & Kurts, C. (2010). Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. NAT IMMUNOL, 11(4), 313-320. [4]. http://www.ncbi.nlm.nih.gov/pubmed/20190758?dopt=Citation

Vancouver

Semmling V, Lukacs-Kornek V, Thaiss CA, Quast T, Hochheiser K, Panzer U et al. Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. NAT IMMUNOL. 2010;11(4):313-320. 4.

Bibtex

@article{cc4f816c09724993ab98acffbfdeddd5,
title = "Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.",
abstract = "Cross-priming allows dendritic cells (DCs) to induce cytotoxic T cell (CTL) responses to extracellular antigens. DCs require cognate 'licensing' for cross-priming, classically by helper T cells. Here we demonstrate an alternative mechanism for cognate licensing by natural killer T (NKT) cells recognizing microbial or synthetic glycolipid antigens. Such licensing caused cross-priming CD8alpha(+) DCs to produce the chemokine CCL17, which attracted naive CTLs expressing the chemokine receptor CCR4. In contrast, DCs licensed by helper T cells recruited CTLs using CCR5 ligands. Thus, depending on the type of antigen they encounter, DCs can be licensed for cross-priming by NKT cells or helper T cells and use at least two independent chemokine pathways to attract naive CTLs. Because these chemokines acted synergistically, this can potentially be exploited to improve vaccinations.",
author = "Verena Semmling and Veronika Lukacs-Kornek and Thaiss, {Christoph A} and Thomas Quast and Katharina Hochheiser and Ulf Panzer and Jamie Rossjohn and Patrick Perlmutter and Jia Cao and Godfrey, {Dale I} and Savage, {Paul B} and Knolle, {Percy A} and Waldemar Kolanus and Irmgard F{\"o}rster and Christian Kurts",
year = "2010",
language = "Deutsch",
volume = "11",
pages = "313--320",
journal = "NAT IMMUNOL",
issn = "1529-2908",
publisher = "NATURE PUBLISHING GROUP",
number = "4",

}

RIS

TY - JOUR

T1 - Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.

AU - Semmling, Verena

AU - Lukacs-Kornek, Veronika

AU - Thaiss, Christoph A

AU - Quast, Thomas

AU - Hochheiser, Katharina

AU - Panzer, Ulf

AU - Rossjohn, Jamie

AU - Perlmutter, Patrick

AU - Cao, Jia

AU - Godfrey, Dale I

AU - Savage, Paul B

AU - Knolle, Percy A

AU - Kolanus, Waldemar

AU - Förster, Irmgard

AU - Kurts, Christian

PY - 2010

Y1 - 2010

N2 - Cross-priming allows dendritic cells (DCs) to induce cytotoxic T cell (CTL) responses to extracellular antigens. DCs require cognate 'licensing' for cross-priming, classically by helper T cells. Here we demonstrate an alternative mechanism for cognate licensing by natural killer T (NKT) cells recognizing microbial or synthetic glycolipid antigens. Such licensing caused cross-priming CD8alpha(+) DCs to produce the chemokine CCL17, which attracted naive CTLs expressing the chemokine receptor CCR4. In contrast, DCs licensed by helper T cells recruited CTLs using CCR5 ligands. Thus, depending on the type of antigen they encounter, DCs can be licensed for cross-priming by NKT cells or helper T cells and use at least two independent chemokine pathways to attract naive CTLs. Because these chemokines acted synergistically, this can potentially be exploited to improve vaccinations.

AB - Cross-priming allows dendritic cells (DCs) to induce cytotoxic T cell (CTL) responses to extracellular antigens. DCs require cognate 'licensing' for cross-priming, classically by helper T cells. Here we demonstrate an alternative mechanism for cognate licensing by natural killer T (NKT) cells recognizing microbial or synthetic glycolipid antigens. Such licensing caused cross-priming CD8alpha(+) DCs to produce the chemokine CCL17, which attracted naive CTLs expressing the chemokine receptor CCR4. In contrast, DCs licensed by helper T cells recruited CTLs using CCR5 ligands. Thus, depending on the type of antigen they encounter, DCs can be licensed for cross-priming by NKT cells or helper T cells and use at least two independent chemokine pathways to attract naive CTLs. Because these chemokines acted synergistically, this can potentially be exploited to improve vaccinations.

M3 - SCORING: Zeitschriftenaufsatz

VL - 11

SP - 313

EP - 320

JO - NAT IMMUNOL

JF - NAT IMMUNOL

SN - 1529-2908

IS - 4

M1 - 4

ER -