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Altering the course of schizophrenia: progress and perspectives

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Altering the course of schizophrenia: progress and perspectives. / Millan, Mark J; Andrieux, Annie; Bartzokis, George; Cadenhead, Kristin; Dazzan, Paola; Fusar-Poli, Paolo; Gallinat, Jürgen; Giedd, Jay; Grayson, Dennis R; Heinrichs, Markus; Kahn, René; Krebs, Marie-Odile; Leboyer, Marion; Lewis, David; Marin, Oscar; Marin, Philippe; Meyer-Lindenberg, Andreas; McGorry, Patrick; McGuire, Philip; Owen, Michael J; Patterson, Paul; Sawa, Akira; Spedding, Michael; Uhlhaas, Peter; Vaccarino, Flora; Wahlestedt, Claes; Weinberger, Daniel.

in: NAT REV DRUG DISCOV, Jahrgang 15, Nr. 7, 07.2016, S. 485-515.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Millan, MJ, Andrieux, A, Bartzokis, G, Cadenhead, K, Dazzan, P, Fusar-Poli, P, Gallinat, J, Giedd, J, Grayson, DR, Heinrichs, M, Kahn, R, Krebs, M-O, Leboyer, M, Lewis, D, Marin, O, Marin, P, Meyer-Lindenberg, A, McGorry, P, McGuire, P, Owen, MJ, Patterson, P, Sawa, A, Spedding, M, Uhlhaas, P, Vaccarino, F, Wahlestedt, C & Weinberger, D 2016, 'Altering the course of schizophrenia: progress and perspectives', NAT REV DRUG DISCOV, Jg. 15, Nr. 7, S. 485-515. https://doi.org/10.1038/nrd.2016.28

APA

Millan, M. J., Andrieux, A., Bartzokis, G., Cadenhead, K., Dazzan, P., Fusar-Poli, P., Gallinat, J., Giedd, J., Grayson, D. R., Heinrichs, M., Kahn, R., Krebs, M-O., Leboyer, M., Lewis, D., Marin, O., Marin, P., Meyer-Lindenberg, A., McGorry, P., McGuire, P., ... Weinberger, D. (2016). Altering the course of schizophrenia: progress and perspectives. NAT REV DRUG DISCOV, 15(7), 485-515. https://doi.org/10.1038/nrd.2016.28

Vancouver

Millan MJ, Andrieux A, Bartzokis G, Cadenhead K, Dazzan P, Fusar-Poli P et al. Altering the course of schizophrenia: progress and perspectives. NAT REV DRUG DISCOV. 2016 Jul;15(7):485-515. https://doi.org/10.1038/nrd.2016.28

Bibtex

@article{f8969b84b09c44dfb226c41fa15a70ba,
title = "Altering the course of schizophrenia: progress and perspectives",
abstract = "Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its genetic and environmental causes has considerably improved, and their relationship to aberrant patterns of neurodevelopment has become clearer. This raises the possibility that 'disease-modifying' strategies could alter the course to - and of - this debilitating disorder, rather than simply alleviating symptoms. A promising window for course-altering intervention is around the time of the first episode of psychosis, especially in young people at risk of transition to schizophrenia. Indeed, studies performed in both individuals at risk of developing schizophrenia and rodent models for schizophrenia suggest that pre-diagnostic pharmacotherapy and psychosocial or cognitive-behavioural interventions can delay or moderate the emergence of psychosis. Of particular interest are 'hybrid' strategies that both relieve presenting symptoms and reduce the risk of transition to schizophrenia or another psychiatric disorder. This Review aims to provide a broad-based consideration of the challenges and opportunities inherent in efforts to alter the course of schizophrenia.",
keywords = "Journal Article",
author = "Millan, {Mark J} and Annie Andrieux and George Bartzokis and Kristin Cadenhead and Paola Dazzan and Paolo Fusar-Poli and J{\"u}rgen Gallinat and Jay Giedd and Grayson, {Dennis R} and Markus Heinrichs and Ren{\'e} Kahn and Marie-Odile Krebs and Marion Leboyer and David Lewis and Oscar Marin and Philippe Marin and Andreas Meyer-Lindenberg and Patrick McGorry and Philip McGuire and Owen, {Michael J} and Paul Patterson and Akira Sawa and Michael Spedding and Peter Uhlhaas and Flora Vaccarino and Claes Wahlestedt and Daniel Weinberger",
year = "2016",
month = jul,
doi = "10.1038/nrd.2016.28",
language = "English",
volume = "15",
pages = "485--515",
journal = "NAT REV DRUG DISCOV",
issn = "1474-1776",
publisher = "NATURE PUBLISHING GROUP",
number = "7",

}

RIS

TY - JOUR

T1 - Altering the course of schizophrenia: progress and perspectives

AU - Millan, Mark J

AU - Andrieux, Annie

AU - Bartzokis, George

AU - Cadenhead, Kristin

AU - Dazzan, Paola

AU - Fusar-Poli, Paolo

AU - Gallinat, Jürgen

AU - Giedd, Jay

AU - Grayson, Dennis R

AU - Heinrichs, Markus

AU - Kahn, René

AU - Krebs, Marie-Odile

AU - Leboyer, Marion

AU - Lewis, David

AU - Marin, Oscar

AU - Marin, Philippe

AU - Meyer-Lindenberg, Andreas

AU - McGorry, Patrick

AU - McGuire, Philip

AU - Owen, Michael J

AU - Patterson, Paul

AU - Sawa, Akira

AU - Spedding, Michael

AU - Uhlhaas, Peter

AU - Vaccarino, Flora

AU - Wahlestedt, Claes

AU - Weinberger, Daniel

PY - 2016/7

Y1 - 2016/7

N2 - Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its genetic and environmental causes has considerably improved, and their relationship to aberrant patterns of neurodevelopment has become clearer. This raises the possibility that 'disease-modifying' strategies could alter the course to - and of - this debilitating disorder, rather than simply alleviating symptoms. A promising window for course-altering intervention is around the time of the first episode of psychosis, especially in young people at risk of transition to schizophrenia. Indeed, studies performed in both individuals at risk of developing schizophrenia and rodent models for schizophrenia suggest that pre-diagnostic pharmacotherapy and psychosocial or cognitive-behavioural interventions can delay or moderate the emergence of psychosis. Of particular interest are 'hybrid' strategies that both relieve presenting symptoms and reduce the risk of transition to schizophrenia or another psychiatric disorder. This Review aims to provide a broad-based consideration of the challenges and opportunities inherent in efforts to alter the course of schizophrenia.

AB - Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its genetic and environmental causes has considerably improved, and their relationship to aberrant patterns of neurodevelopment has become clearer. This raises the possibility that 'disease-modifying' strategies could alter the course to - and of - this debilitating disorder, rather than simply alleviating symptoms. A promising window for course-altering intervention is around the time of the first episode of psychosis, especially in young people at risk of transition to schizophrenia. Indeed, studies performed in both individuals at risk of developing schizophrenia and rodent models for schizophrenia suggest that pre-diagnostic pharmacotherapy and psychosocial or cognitive-behavioural interventions can delay or moderate the emergence of psychosis. Of particular interest are 'hybrid' strategies that both relieve presenting symptoms and reduce the risk of transition to schizophrenia or another psychiatric disorder. This Review aims to provide a broad-based consideration of the challenges and opportunities inherent in efforts to alter the course of schizophrenia.

KW - Journal Article

U2 - 10.1038/nrd.2016.28

DO - 10.1038/nrd.2016.28

M3 - SCORING: Journal article

C2 - 26939910

VL - 15

SP - 485

EP - 515

JO - NAT REV DRUG DISCOV

JF - NAT REV DRUG DISCOV

SN - 1474-1776

IS - 7

ER -