Altered Coupling of Psychological Relaxation and Regional Volume of Brain Reward Areas in Multiple Sclerosis
Beteiligte Einrichtungen
Abstract
Methods: Semistructured interviews were performed with 23 people with MS: 11 receiving first-line treatment and 12 receiving second-line treatment. Medication history, experiences with previous medications, decision-making processes regarding immunotherapy, adherence behavior, and reasons for adherence/nonadherence were explored using open-ended questions. Qualitative content analysis was performed using a combined deductive-inductive approach in building a coding frame. Differences in coding frequencies were compared between the two groups and analyzed quantitatively. Cohen's kappas of 0.76 for people with MS receiving first-line treatment and 0.64 for the second-line sample were achieved between the two coders.
Results: One key reason for nonadherence reported by first-line-treated people with MS was burdensome side effects, and for adherence was belief in medication effectiveness. In people with MS receiving second-line treatment, lack of perceived medication effectiveness was a key category related to changes in or discontinuation of immunotherapy. Reasons for adherence were positive illness beliefs/perceptions and belief in highly active disease. Intentional nonadherence was a major issue for first-line treatment and less relevant for second-line treatment.
Conclusions: These results indicate specific differences in factors mitigating adherence in people with MS receiving first- and second-line treatment.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 1664-2295 |
DOIs | |
Status | Veröffentlicht - 06.10.2020 |
Anmerkungen des Dekanats
Copyright © 2020 Wakonig, Eitel, Ritter, Hetzer, Schmitz-Hübsch, Bellmann-Strobl, Haynes, Brandt, Gold, Paul and Weygandt.
PubMed | 33117263 |
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