PortalPublikationenAlteration of topoisomerase II-alpha gene in human breast ca...

Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy.

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  • Michael F Press
  • Guido Sauter
  • Marc Buyse
  • Leslie Bernstein
  • Roberta Guzman
  • Angela Santiago
  • Ivonne E Villalobos
  • Wolfgang Eiermann
  • Tadeusz Pienkowski
  • Miguel Martin
  • Nicholas Robert
  • John Crown
  • Valerie Bee
  • Henry Taupin
  • Kerry J Flom
  • Isabelle Tabah-Fisch
  • Giovanni Pauletti
  • Mary-Ann Lindsay
  • Alessandro Riva
  • Dennis J Slamon

Beteiligte Einrichtungen

Abstract

Approximately 35% of HER2-amplified breast cancers have coamplification of the topoisomerase II-alpha (TOP2A) gene encoding an enzyme that is a major target of anthracyclines. This study was designed to evaluate whether TOP2A gene alterations may predict incremental responsiveness to anthracyclines in some breast cancers.

Bibliografische Daten

OriginalspracheEnglisch
Aufsatznummer7
ISSN0732-183X
StatusVeröffentlicht - 2011
pubmed 21189395