Alport syndrome and pregnancy.
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Alport syndrome and pregnancy. / Matsuo, Koji; Tudor, Erika L; Baschat, Ahmet.
in: OBSTET GYNECOL, Jahrgang 109(2 Pt2), 2007, S. 531-532.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Alport syndrome and pregnancy.
AU - Matsuo, Koji
AU - Tudor, Erika L
AU - Baschat, Ahmet
PY - 2007
Y1 - 2007
N2 - BACKGROUND: Alport syndrome is a disorder associated with mutations in the type IV collagen gene and manifested by progressive glomerulonephritis. Little is known about the effect of Alport syndrome on pregnancy outcome. CASE: We report a patient with Alport syndrome whose pregnancy was complicated by rapidly progressive severe preeclampsia, fetal growth restriction, and acute renal failure. At 25 weeks of gestation, termination of pregnancy was performed. The patient's renal function was well controlled before pregnancy, but had not recovered at 6 months postpartum, requiring ongoing hemodialysis. CONCLUSION: Alport syndrome in pregnancy has the potential for disease acceleration with rapid parallel progression of vasculopathy in the placental and renal circulations.
AB - BACKGROUND: Alport syndrome is a disorder associated with mutations in the type IV collagen gene and manifested by progressive glomerulonephritis. Little is known about the effect of Alport syndrome on pregnancy outcome. CASE: We report a patient with Alport syndrome whose pregnancy was complicated by rapidly progressive severe preeclampsia, fetal growth restriction, and acute renal failure. At 25 weeks of gestation, termination of pregnancy was performed. The patient's renal function was well controlled before pregnancy, but had not recovered at 6 months postpartum, requiring ongoing hemodialysis. CONCLUSION: Alport syndrome in pregnancy has the potential for disease acceleration with rapid parallel progression of vasculopathy in the placental and renal circulations.
M3 - SCORING: Zeitschriftenaufsatz
VL - 109(2 Pt2)
SP - 531
EP - 532
ER -