PortalPublikationenAllogenic Blood Transfusion is Associated with Poor Perioper...

Allogenic Blood Transfusion is Associated with Poor Perioperative and Long-Term Outcome in Esophageal Cancer

Standard

Allogenic Blood Transfusion is Associated with Poor Perioperative and Long-Term Outcome in Esophageal Cancer. / Reeh, Matthias; Ghadban, Tarik; Dedow, Josephine; Vettorazzi, Eik; Uzunoglu, Faik G; Nentwich, Michael; Kluge, Stefan; Izbicki, Jakob R; Vashist, Yogesh K.

in: WORLD J SURG, Jahrgang 41, Nr. 1, 01.2017, S. 208-215.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Reeh, M, Ghadban, T, Dedow, J, Vettorazzi, E, Uzunoglu, FG, Nentwich, M, Kluge, S, Izbicki, JR & Vashist, YK 2017, 'Allogenic Blood Transfusion is Associated with Poor Perioperative and Long-Term Outcome in Esophageal Cancer', WORLD J SURG, Jg. 41, Nr. 1, S. 208-215. https://doi.org/10.1007/s00268-016-3730-8

APA

Reeh, M., Ghadban, T., Dedow, J., Vettorazzi, E., Uzunoglu, F. G., Nentwich, M., Kluge, S., Izbicki, J. R., & Vashist, Y. K. (2017). Allogenic Blood Transfusion is Associated with Poor Perioperative and Long-Term Outcome in Esophageal Cancer. WORLD J SURG, 41(1), 208-215. https://doi.org/10.1007/s00268-016-3730-8

Vancouver

Reeh M, Ghadban T, Dedow J, Vettorazzi E, Uzunoglu FG, Nentwich M et al. Allogenic Blood Transfusion is Associated with Poor Perioperative and Long-Term Outcome in Esophageal Cancer. WORLD J SURG. 2017 Jan;41(1):208-215. https://doi.org/10.1007/s00268-016-3730-8

Bibtex

@article{69656cb975e34c9994183e26d130d890,
title = "Allogenic Blood Transfusion is Associated with Poor Perioperative and Long-Term Outcome in Esophageal Cancer",
abstract = "BACKGROUND: Esophageal resection for cancer (EC) is still associated with considerable mortality and morbidity rates. Allogenic blood transfusion (aBT) is associated with poor short-term and long-term outcome in surgical oncology. We aimed to evaluate the effect of aBT in a homogeneous population of EC patients undergoing esophagectomy without perioperative treatment.METHODS: We analyzed 565 esophagectomies performed due to EC. Allogenic blood transfusion was correlated to clinicopathological parameters, perioperative mortality and morbidity as well as the long-term outcome. Results are presented as adjusted odds ratio (OR) or hazard ratio (HR) with 95 % confidence interval (95 % CI).RESULTS: Patients receiving aBT (aBT(+)) had no higher tumor stages or higher rates of lymph node metastasis (P = 0.65 and 0.17, respectively) compared to patients without aBT (aBT(-)). Allogenic blood transfusion was strongly associated with perioperative morbidity (OR 1.9, 95 % CI 1.1-3.5, P = 0.02) and mortality (OR 2.9, 95 % CI 1.0-8.6, P = 0.04). Tumor recurrence rate was significantly higher in aBT(+) patients (P = 0.001). The disease-free and overall survival were significantly longer in aBT(-) compared to aBT(+) patients (P = 0.016 and <0.001, respectively). Patients receiving aBT had almost doubled risk for tumor recurrence (HR 1.8, 95 % CI 1.2-2.5, P = 0.001) and death (HR 2.2, 95 % CI 1.5-3.2, P < 0.001).CONCLUSION: Allogenic blood transfusion has a significant impact on the natural course of EC after complete resection. The poor short-term and long-term outcome warrants further evaluation of the underlying molecular mechanisms induced by allogenic blood transfusion in cancer patients.",
author = "Matthias Reeh and Tarik Ghadban and Josephine Dedow and Eik Vettorazzi and Uzunoglu, {Faik G} and Michael Nentwich and Stefan Kluge and Izbicki, {Jakob R} and Vashist, {Yogesh K}",
year = "2017",
month = jan,
doi = "10.1007/s00268-016-3730-8",
language = "English",
volume = "41",
pages = "208--215",
journal = "WORLD J SURG",
issn = "0364-2313",
publisher = "Springer New York",
number = "1",

}

RIS

TY - JOUR

T1 - Allogenic Blood Transfusion is Associated with Poor Perioperative and Long-Term Outcome in Esophageal Cancer

AU - Reeh, Matthias

AU - Ghadban, Tarik

AU - Dedow, Josephine

AU - Vettorazzi, Eik

AU - Uzunoglu, Faik G

AU - Nentwich, Michael

AU - Kluge, Stefan

AU - Izbicki, Jakob R

AU - Vashist, Yogesh K

PY - 2017/1

Y1 - 2017/1

N2 - BACKGROUND: Esophageal resection for cancer (EC) is still associated with considerable mortality and morbidity rates. Allogenic blood transfusion (aBT) is associated with poor short-term and long-term outcome in surgical oncology. We aimed to evaluate the effect of aBT in a homogeneous population of EC patients undergoing esophagectomy without perioperative treatment.METHODS: We analyzed 565 esophagectomies performed due to EC. Allogenic blood transfusion was correlated to clinicopathological parameters, perioperative mortality and morbidity as well as the long-term outcome. Results are presented as adjusted odds ratio (OR) or hazard ratio (HR) with 95 % confidence interval (95 % CI).RESULTS: Patients receiving aBT (aBT(+)) had no higher tumor stages or higher rates of lymph node metastasis (P = 0.65 and 0.17, respectively) compared to patients without aBT (aBT(-)). Allogenic blood transfusion was strongly associated with perioperative morbidity (OR 1.9, 95 % CI 1.1-3.5, P = 0.02) and mortality (OR 2.9, 95 % CI 1.0-8.6, P = 0.04). Tumor recurrence rate was significantly higher in aBT(+) patients (P = 0.001). The disease-free and overall survival were significantly longer in aBT(-) compared to aBT(+) patients (P = 0.016 and <0.001, respectively). Patients receiving aBT had almost doubled risk for tumor recurrence (HR 1.8, 95 % CI 1.2-2.5, P = 0.001) and death (HR 2.2, 95 % CI 1.5-3.2, P < 0.001).CONCLUSION: Allogenic blood transfusion has a significant impact on the natural course of EC after complete resection. The poor short-term and long-term outcome warrants further evaluation of the underlying molecular mechanisms induced by allogenic blood transfusion in cancer patients.

AB - BACKGROUND: Esophageal resection for cancer (EC) is still associated with considerable mortality and morbidity rates. Allogenic blood transfusion (aBT) is associated with poor short-term and long-term outcome in surgical oncology. We aimed to evaluate the effect of aBT in a homogeneous population of EC patients undergoing esophagectomy without perioperative treatment.METHODS: We analyzed 565 esophagectomies performed due to EC. Allogenic blood transfusion was correlated to clinicopathological parameters, perioperative mortality and morbidity as well as the long-term outcome. Results are presented as adjusted odds ratio (OR) or hazard ratio (HR) with 95 % confidence interval (95 % CI).RESULTS: Patients receiving aBT (aBT(+)) had no higher tumor stages or higher rates of lymph node metastasis (P = 0.65 and 0.17, respectively) compared to patients without aBT (aBT(-)). Allogenic blood transfusion was strongly associated with perioperative morbidity (OR 1.9, 95 % CI 1.1-3.5, P = 0.02) and mortality (OR 2.9, 95 % CI 1.0-8.6, P = 0.04). Tumor recurrence rate was significantly higher in aBT(+) patients (P = 0.001). The disease-free and overall survival were significantly longer in aBT(-) compared to aBT(+) patients (P = 0.016 and <0.001, respectively). Patients receiving aBT had almost doubled risk for tumor recurrence (HR 1.8, 95 % CI 1.2-2.5, P = 0.001) and death (HR 2.2, 95 % CI 1.5-3.2, P < 0.001).CONCLUSION: Allogenic blood transfusion has a significant impact on the natural course of EC after complete resection. The poor short-term and long-term outcome warrants further evaluation of the underlying molecular mechanisms induced by allogenic blood transfusion in cancer patients.

U2 - 10.1007/s00268-016-3730-8

DO - 10.1007/s00268-016-3730-8

M3 - SCORING: Journal article

C2 - 27730355

VL - 41

SP - 208

EP - 215

JO - WORLD J SURG

JF - WORLD J SURG

SN - 0364-2313

IS - 1

ER -