Allogeneic stem cell transplantation for elderly patients with myelodysplastic syndrome.

TY - JOUR

T1 - Allogeneic stem cell transplantation for elderly patients with myelodysplastic syndrome.

AU - Kröger, Nicolaus

PY - 2012

Y1 - 2012

N2 - Allogeneic hematopoietic stem cell transplantation (SCT) is well accepted as a curative treatment approach for younger patients with myelodysplastic syndrome (MDS) and has become one of the most frequent indications for allogeneic SCT as reported to the Center for International Blood and Marrow Transplant Research. However, MDS patients are usually elderly with a median age of approximately 75 years at diagnosis. Large register studies have confirmed the feasibility of the procedure in elderly MDS patients; and in the register of the European Group for Blood and Marrow Transplantation, one-third of the allogeneic transplant procedures for MDS were performed in 2010 in patients older than 60 years. Despite its curative potential, its role in the treatment of elderly MDS patients is less defined. Because of the inherent complications of the transplantation leading to treatment-related mortality and the risk of relapse, a careful calculation of the benefit for each patient is mandatory, taking into account comorbidities, disease status, donor selection, and effective nontransplant therapies. Prospective multicenter studies are needed to define optimal intensity of the conditioning regimen, timing of transplantation within a treatment algorithm, including drug-based therapies, and posttransplant strategies to reduce the risk of relapse.

AB - Allogeneic hematopoietic stem cell transplantation (SCT) is well accepted as a curative treatment approach for younger patients with myelodysplastic syndrome (MDS) and has become one of the most frequent indications for allogeneic SCT as reported to the Center for International Blood and Marrow Transplant Research. However, MDS patients are usually elderly with a median age of approximately 75 years at diagnosis. Large register studies have confirmed the feasibility of the procedure in elderly MDS patients; and in the register of the European Group for Blood and Marrow Transplantation, one-third of the allogeneic transplant procedures for MDS were performed in 2010 in patients older than 60 years. Despite its curative potential, its role in the treatment of elderly MDS patients is less defined. Because of the inherent complications of the transplantation leading to treatment-related mortality and the risk of relapse, a careful calculation of the benefit for each patient is mandatory, taking into account comorbidities, disease status, donor selection, and effective nontransplant therapies. Prospective multicenter studies are needed to define optimal intensity of the conditioning regimen, timing of transplantation within a treatment algorithm, including drug-based therapies, and posttransplant strategies to reduce the risk of relapse.

KW - Humans

KW - Aged

KW - Treatment Outcome

KW - Transplantation, Homologous

KW - Stem Cell Transplantation

KW - Transplantation Conditioning

KW - Iron Overload/complications

KW - Myelodysplastic Syndromes/complications/genetics/therapy

KW - Humans

KW - Aged

KW - Treatment Outcome

KW - Transplantation, Homologous

KW - Stem Cell Transplantation

KW - Transplantation Conditioning

KW - Iron Overload/complications

KW - Myelodysplastic Syndromes/complications/genetics/therapy

U2 - 10.1182/blood-2011-12-380162

DO - 10.1182/blood-2011-12-380162

M3 - SCORING: Journal article

C2 - 22504927

VL - 119

SP - 5632

EP - 5639

JO - BLOOD

JF - BLOOD

SN - 0006-4971

IS - 24

M1 - 24

ER -