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Allogeneic haematopoietic cell transplantation offers the chance of cure for patients with transformed follicular lymphoma

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Allogeneic haematopoietic cell transplantation offers the chance of cure for patients with transformed follicular lymphoma. / Heinzelmann, Frank; Bethge, Wolfgang; Beelen, Dietrich Wilhelm; Stelljes, Matthias; Dreger, Peter; Engelhard, Marianne; Finke, Jürgen; Kröger, Nikolaus; Holler, Ernst; Bornhäuser, Martin; Müller, Annerose; Haubitz, Imme; Ottinger, Hellmut.

in: J CANCER RES CLIN, Jahrgang 144, Nr. 6, 06.2018, S. 1173-1183.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Heinzelmann, F, Bethge, W, Beelen, DW, Stelljes, M, Dreger, P, Engelhard, M, Finke, J, Kröger, N, Holler, E, Bornhäuser, M, Müller, A, Haubitz, I & Ottinger, H 2018, 'Allogeneic haematopoietic cell transplantation offers the chance of cure for patients with transformed follicular lymphoma', J CANCER RES CLIN, Jg. 144, Nr. 6, S. 1173-1183. https://doi.org/10.1007/s00432-018-2633-5

APA

Heinzelmann, F., Bethge, W., Beelen, D. W., Stelljes, M., Dreger, P., Engelhard, M., Finke, J., Kröger, N., Holler, E., Bornhäuser, M., Müller, A., Haubitz, I., & Ottinger, H. (2018). Allogeneic haematopoietic cell transplantation offers the chance of cure for patients with transformed follicular lymphoma. J CANCER RES CLIN, 144(6), 1173-1183. https://doi.org/10.1007/s00432-018-2633-5

Vancouver

Heinzelmann F, Bethge W, Beelen DW, Stelljes M, Dreger P, Engelhard M et al. Allogeneic haematopoietic cell transplantation offers the chance of cure for patients with transformed follicular lymphoma. J CANCER RES CLIN. 2018 Jun;144(6):1173-1183. https://doi.org/10.1007/s00432-018-2633-5

Bibtex

@article{15f2cc986f2946c9a5734508be81d302,
title = "Allogeneic haematopoietic cell transplantation offers the chance of cure for patients with transformed follicular lymphoma",
abstract = "PURPOSE: In patients with follicular lymphoma, secondary transformation to aggressive lymphoma (tFL) implies a poor prognosis. In principle, allogeneic haematopoietic cell transplantation (allo-HCT) offers a chance of cure for tFL but is rarely practiced. Aim of this retrospective multicenter study was to define the actual significance of allo-HCT in treatment of tFL.METHODS: The database of the German Registry for Stem Cell Transplantation (DRST) was screened for patients who underwent allo-HCT for tFL 1998-2008. Confirmation of tFL-diagnosis by local and/or pathologists of the National NHL Board was mandatory for enrolment. Gaps in reported EBMT Minimum Essential Data datasets (MED-A) were filled by local DRST data managers. Relevant HCT outcome variables were evaluated by uni- and multivariate statistical analysis.RESULTS: Median age of enrolled 33 patients was 51 years with a post allo-HCT median follow-up of 7.1 years of surviving patients. At time of HCT 24/33 patients had chemosensitive disease. In 24/33 patients reduced intensity conditioning (RIC) was used. Estimated 1, 2, 5-year overall survival (OS) and event-free survival rates were 49/39/33, and 33/30/24%. Cumulative 100 days non-relapse mortality was 25%. Chemosensitive disease, RIC, and limited chronic GvHD were identified as independent prognostic factors for OS.CONCLUSIONS: Allo-HCT offers the chance of cure for tFL.",
keywords = "Adult, Aged, Cell Transformation, Neoplastic, Female, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Lymphoma, Follicular, Male, Middle Aged, Prognosis, Retrospective Studies, Transplantation, Homologous, Journal Article",
author = "Frank Heinzelmann and Wolfgang Bethge and Beelen, {Dietrich Wilhelm} and Matthias Stelljes and Peter Dreger and Marianne Engelhard and J{\"u}rgen Finke and Nikolaus Kr{\"o}ger and Ernst Holler and Martin Bornh{\"a}user and Annerose M{\"u}ller and Imme Haubitz and Hellmut Ottinger",
year = "2018",
month = jun,
doi = "10.1007/s00432-018-2633-5",
language = "English",
volume = "144",
pages = "1173--1183",
journal = "J CANCER RES CLIN",
issn = "0171-5216",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Allogeneic haematopoietic cell transplantation offers the chance of cure for patients with transformed follicular lymphoma

AU - Heinzelmann, Frank

AU - Bethge, Wolfgang

AU - Beelen, Dietrich Wilhelm

AU - Stelljes, Matthias

AU - Dreger, Peter

AU - Engelhard, Marianne

AU - Finke, Jürgen

AU - Kröger, Nikolaus

AU - Holler, Ernst

AU - Bornhäuser, Martin

AU - Müller, Annerose

AU - Haubitz, Imme

AU - Ottinger, Hellmut

PY - 2018/6

Y1 - 2018/6

N2 - PURPOSE: In patients with follicular lymphoma, secondary transformation to aggressive lymphoma (tFL) implies a poor prognosis. In principle, allogeneic haematopoietic cell transplantation (allo-HCT) offers a chance of cure for tFL but is rarely practiced. Aim of this retrospective multicenter study was to define the actual significance of allo-HCT in treatment of tFL.METHODS: The database of the German Registry for Stem Cell Transplantation (DRST) was screened for patients who underwent allo-HCT for tFL 1998-2008. Confirmation of tFL-diagnosis by local and/or pathologists of the National NHL Board was mandatory for enrolment. Gaps in reported EBMT Minimum Essential Data datasets (MED-A) were filled by local DRST data managers. Relevant HCT outcome variables were evaluated by uni- and multivariate statistical analysis.RESULTS: Median age of enrolled 33 patients was 51 years with a post allo-HCT median follow-up of 7.1 years of surviving patients. At time of HCT 24/33 patients had chemosensitive disease. In 24/33 patients reduced intensity conditioning (RIC) was used. Estimated 1, 2, 5-year overall survival (OS) and event-free survival rates were 49/39/33, and 33/30/24%. Cumulative 100 days non-relapse mortality was 25%. Chemosensitive disease, RIC, and limited chronic GvHD were identified as independent prognostic factors for OS.CONCLUSIONS: Allo-HCT offers the chance of cure for tFL.

AB - PURPOSE: In patients with follicular lymphoma, secondary transformation to aggressive lymphoma (tFL) implies a poor prognosis. In principle, allogeneic haematopoietic cell transplantation (allo-HCT) offers a chance of cure for tFL but is rarely practiced. Aim of this retrospective multicenter study was to define the actual significance of allo-HCT in treatment of tFL.METHODS: The database of the German Registry for Stem Cell Transplantation (DRST) was screened for patients who underwent allo-HCT for tFL 1998-2008. Confirmation of tFL-diagnosis by local and/or pathologists of the National NHL Board was mandatory for enrolment. Gaps in reported EBMT Minimum Essential Data datasets (MED-A) were filled by local DRST data managers. Relevant HCT outcome variables were evaluated by uni- and multivariate statistical analysis.RESULTS: Median age of enrolled 33 patients was 51 years with a post allo-HCT median follow-up of 7.1 years of surviving patients. At time of HCT 24/33 patients had chemosensitive disease. In 24/33 patients reduced intensity conditioning (RIC) was used. Estimated 1, 2, 5-year overall survival (OS) and event-free survival rates were 49/39/33, and 33/30/24%. Cumulative 100 days non-relapse mortality was 25%. Chemosensitive disease, RIC, and limited chronic GvHD were identified as independent prognostic factors for OS.CONCLUSIONS: Allo-HCT offers the chance of cure for tFL.

KW - Adult

KW - Aged

KW - Cell Transformation, Neoplastic

KW - Female

KW - Graft vs Host Disease

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Lymphoma, Follicular

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Retrospective Studies

KW - Transplantation, Homologous

KW - Journal Article

U2 - 10.1007/s00432-018-2633-5

DO - 10.1007/s00432-018-2633-5

M3 - SCORING: Journal article

C2 - 29623467

VL - 144

SP - 1173

EP - 1183

JO - J CANCER RES CLIN

JF - J CANCER RES CLIN

SN - 0171-5216

IS - 6

ER -