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Algorithm for Rapid Exclusion of Clinically Relevant Plasma Levels of Direct Oral Anticoagulants in Patients Using the DOAC Dipstick

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Algorithm for Rapid Exclusion of Clinically Relevant Plasma Levels of Direct Oral Anticoagulants in Patients Using the DOAC Dipstick. / Harenberg, Job; Gosselin, Robert Charles; Cuker, Adam; Becattini, Cecilia; Pabinger, Ingrid; Poli, Sven; Weitz, Jeffrey Ian; Ageno, Walter; Bauersachs, Rupert; Ćelap, Ivana; Choi, Philip; Douketis, James; Douxfils, Jonathan; Elalamy, Ismail; Fareed, Jawed; Falanga, Anna; Favalor, Emmanuel; Gerotziafas, Grigoris T; Herkner, Harald; Hetjens, Svetlana; Klamroth, Robert; Heubner, Lars; Langer, Florian; Lip, Gregory Yh; Mac Grory, Brain; Margetić, Sandra; Merrelaar, Anne; Pikta, Marika; Renne', Thomas; Schwameis, Michael; Schulman, Sam; Strbian, Daniel; Tafur, Alfonso; Violi, Francesco; Vassart, Julie; Walenga, Jeanine; Weiss, Christel.

in: THROMB HAEMOSTASIS, Jahrgang 124, Nr. 8, 08.2024, S. 770-777.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Harenberg, J, Gosselin, RC, Cuker, A, Becattini, C, Pabinger, I, Poli, S, Weitz, JI, Ageno, W, Bauersachs, R, Ćelap, I, Choi, P, Douketis, J, Douxfils, J, Elalamy, I, Fareed, J, Falanga, A, Favalor, E, Gerotziafas, GT, Herkner, H, Hetjens, S, Klamroth, R, Heubner, L, Langer, F, Lip, GY, Mac Grory, B, Margetić, S, Merrelaar, A, Pikta, M, Renne', T, Schwameis, M, Schulman, S, Strbian, D, Tafur, A, Violi, F, Vassart, J, Walenga, J & Weiss, C 2024, 'Algorithm for Rapid Exclusion of Clinically Relevant Plasma Levels of Direct Oral Anticoagulants in Patients Using the DOAC Dipstick', THROMB HAEMOSTASIS, Jg. 124, Nr. 8, S. 770-777. https://doi.org/10.1055/a-2261-1811

APA

Harenberg, J., Gosselin, R. C., Cuker, A., Becattini, C., Pabinger, I., Poli, S., Weitz, J. I., Ageno, W., Bauersachs, R., Ćelap, I., Choi, P., Douketis, J., Douxfils, J., Elalamy, I., Fareed, J., Falanga, A., Favalor, E., Gerotziafas, G. T., Herkner, H., ... Weiss, C. (2024). Algorithm for Rapid Exclusion of Clinically Relevant Plasma Levels of Direct Oral Anticoagulants in Patients Using the DOAC Dipstick. THROMB HAEMOSTASIS, 124(8), 770-777. https://doi.org/10.1055/a-2261-1811

Vancouver

Harenberg J, Gosselin RC, Cuker A, Becattini C, Pabinger I, Poli S et al. Algorithm for Rapid Exclusion of Clinically Relevant Plasma Levels of Direct Oral Anticoagulants in Patients Using the DOAC Dipstick. THROMB HAEMOSTASIS. 2024 Aug;124(8):770-777. https://doi.org/10.1055/a-2261-1811

Bibtex

@article{11bae89aceeb4d24a7938fa33e461f42,
title = "Algorithm for Rapid Exclusion of Clinically Relevant Plasma Levels of Direct Oral Anticoagulants in Patients Using the DOAC Dipstick",
abstract = "BACKGROUND:  With the widespread use of direct oral anticoagulants (DOACs), there is an urgent need for a rapid assay to exclude clinically relevant plasma levels. Accurate and rapid determination of DOAC levels would guide medical decision-making to (1) determine the potential contribution of the DOAC to spontaneous or trauma-induced hemorrhage; (2) identify appropriate candidates for reversal, or (3) optimize the timing of urgent surgery or intervention.METHODS AND RESULTS:  The DOAC Dipstick test uses a disposable strip to identify factor Xa- or thrombin inhibitors in a urine sample. Based on the results of a systematic literature search followed by an analysis of a simple pooling of five retrieved clinical studies, the test strip has a high sensitivity and an acceptably high negative predictive value when compared with levels measured with liquid chromatography tandem mass spectrometry or calibrated chromogenic assays to reliably exclude plasma DOAC concentrations ≥30 ng/mL.CONCLUSION:  Based on these data, a simple algorithm is proposed to enhance medical decision-making in acute care indications useful primarily in hospitals not having readily available quantitative tests and 24/7. This algorithm not only determines DOAC exposure but also differentiates between factor Xa and thrombin inhibitors to better guide clinical management.",
author = "Job Harenberg and Gosselin, {Robert Charles} and Adam Cuker and Cecilia Becattini and Ingrid Pabinger and Sven Poli and Weitz, {Jeffrey Ian} and Walter Ageno and Rupert Bauersachs and Ivana {\'C}elap and Philip Choi and James Douketis and Jonathan Douxfils and Ismail Elalamy and Jawed Fareed and Anna Falanga and Emmanuel Favalor and Gerotziafas, {Grigoris T} and Harald Herkner and Svetlana Hetjens and Robert Klamroth and Lars Heubner and Florian Langer and Lip, {Gregory Yh} and {Mac Grory}, Brain and Sandra Margeti{\'c} and Anne Merrelaar and Marika Pikta and Thomas Renne' and Michael Schwameis and Sam Schulman and Daniel Strbian and Alfonso Tafur and Francesco Violi and Julie Vassart and Jeanine Walenga and Christel Weiss",
note = "Thieme. All rights reserved.",
year = "2024",
month = aug,
doi = "10.1055/a-2261-1811",
language = "English",
volume = "124",
pages = "770--777",
journal = "THROMB HAEMOSTASIS",
issn = "0340-6245",
publisher = "Schattauer",
number = "8",

}

RIS

TY - JOUR

T1 - Algorithm for Rapid Exclusion of Clinically Relevant Plasma Levels of Direct Oral Anticoagulants in Patients Using the DOAC Dipstick

AU - Harenberg, Job

AU - Gosselin, Robert Charles

AU - Cuker, Adam

AU - Becattini, Cecilia

AU - Pabinger, Ingrid

AU - Poli, Sven

AU - Weitz, Jeffrey Ian

AU - Ageno, Walter

AU - Bauersachs, Rupert

AU - Ćelap, Ivana

AU - Choi, Philip

AU - Douketis, James

AU - Douxfils, Jonathan

AU - Elalamy, Ismail

AU - Fareed, Jawed

AU - Falanga, Anna

AU - Favalor, Emmanuel

AU - Gerotziafas, Grigoris T

AU - Herkner, Harald

AU - Hetjens, Svetlana

AU - Klamroth, Robert

AU - Heubner, Lars

AU - Langer, Florian

AU - Lip, Gregory Yh

AU - Mac Grory, Brain

AU - Margetić, Sandra

AU - Merrelaar, Anne

AU - Pikta, Marika

AU - Renne', Thomas

AU - Schwameis, Michael

AU - Schulman, Sam

AU - Strbian, Daniel

AU - Tafur, Alfonso

AU - Violi, Francesco

AU - Vassart, Julie

AU - Walenga, Jeanine

AU - Weiss, Christel

N1 - Thieme. All rights reserved.

PY - 2024/8

Y1 - 2024/8

N2 - BACKGROUND:  With the widespread use of direct oral anticoagulants (DOACs), there is an urgent need for a rapid assay to exclude clinically relevant plasma levels. Accurate and rapid determination of DOAC levels would guide medical decision-making to (1) determine the potential contribution of the DOAC to spontaneous or trauma-induced hemorrhage; (2) identify appropriate candidates for reversal, or (3) optimize the timing of urgent surgery or intervention.METHODS AND RESULTS:  The DOAC Dipstick test uses a disposable strip to identify factor Xa- or thrombin inhibitors in a urine sample. Based on the results of a systematic literature search followed by an analysis of a simple pooling of five retrieved clinical studies, the test strip has a high sensitivity and an acceptably high negative predictive value when compared with levels measured with liquid chromatography tandem mass spectrometry or calibrated chromogenic assays to reliably exclude plasma DOAC concentrations ≥30 ng/mL.CONCLUSION:  Based on these data, a simple algorithm is proposed to enhance medical decision-making in acute care indications useful primarily in hospitals not having readily available quantitative tests and 24/7. This algorithm not only determines DOAC exposure but also differentiates between factor Xa and thrombin inhibitors to better guide clinical management.

AB - BACKGROUND:  With the widespread use of direct oral anticoagulants (DOACs), there is an urgent need for a rapid assay to exclude clinically relevant plasma levels. Accurate and rapid determination of DOAC levels would guide medical decision-making to (1) determine the potential contribution of the DOAC to spontaneous or trauma-induced hemorrhage; (2) identify appropriate candidates for reversal, or (3) optimize the timing of urgent surgery or intervention.METHODS AND RESULTS:  The DOAC Dipstick test uses a disposable strip to identify factor Xa- or thrombin inhibitors in a urine sample. Based on the results of a systematic literature search followed by an analysis of a simple pooling of five retrieved clinical studies, the test strip has a high sensitivity and an acceptably high negative predictive value when compared with levels measured with liquid chromatography tandem mass spectrometry or calibrated chromogenic assays to reliably exclude plasma DOAC concentrations ≥30 ng/mL.CONCLUSION:  Based on these data, a simple algorithm is proposed to enhance medical decision-making in acute care indications useful primarily in hospitals not having readily available quantitative tests and 24/7. This algorithm not only determines DOAC exposure but also differentiates between factor Xa and thrombin inhibitors to better guide clinical management.

U2 - 10.1055/a-2261-1811

DO - 10.1055/a-2261-1811

M3 - SCORING: Journal article

C2 - 38316416

VL - 124

SP - 770

EP - 777

JO - THROMB HAEMOSTASIS

JF - THROMB HAEMOSTASIS

SN - 0340-6245

IS - 8

ER -