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Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes

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Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes. / Csengeri, Dora; Sprünker, Ngoc-Anh; Di Castelnuovo, Augusto; Niiranen, Teemu; Vishram-Nielsen, Julie Kk; Costanzo, Simona; Söderberg, Stefan; Jensen, Steen M; Vartiainen, Erkki; Donati, Maria Benedetta; Magnussen, Christina; Camen, Stephan; Gianfagna, Francesco; Løchen, Maja-Lisa; Kee, Frank; Kontto, Jukka; Mathiesen, Ellisiv B; Koenig, Wolfgang; Stefan, Blankenberg; de Gaetano, Giovanni; Jørgensen, Torben; Kuulasmaa, Kari; Zeller, Tanja; Salomaa, Veikko; Iacoviello, Licia; Schnabel, Renate B.

in: EUR HEART J, Jahrgang 42, Nr. 12, 21.03.2021, S. 1170-1177.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Csengeri, D, Sprünker, N-A, Di Castelnuovo, A, Niiranen, T, Vishram-Nielsen, JK, Costanzo, S, Söderberg, S, Jensen, SM, Vartiainen, E, Donati, MB, Magnussen, C, Camen, S, Gianfagna, F, Løchen, M-L, Kee, F, Kontto, J, Mathiesen, EB, Koenig, W, Stefan, B, de Gaetano, G, Jørgensen, T, Kuulasmaa, K, Zeller, T, Salomaa, V, Iacoviello, L & Schnabel, RB 2021, 'Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes', EUR HEART J, Jg. 42, Nr. 12, S. 1170-1177. https://doi.org/10.1093/eurheartj/ehaa953

APA

Csengeri, D., Sprünker, N-A., Di Castelnuovo, A., Niiranen, T., Vishram-Nielsen, J. K., Costanzo, S., Söderberg, S., Jensen, S. M., Vartiainen, E., Donati, M. B., Magnussen, C., Camen, S., Gianfagna, F., Løchen, M-L., Kee, F., Kontto, J., Mathiesen, E. B., Koenig, W., Stefan, B., ... Schnabel, R. B. (2021). Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes. EUR HEART J, 42(12), 1170-1177. https://doi.org/10.1093/eurheartj/ehaa953

Vancouver

Csengeri D, Sprünker N-A, Di Castelnuovo A, Niiranen T, Vishram-Nielsen JK, Costanzo S et al. Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes. EUR HEART J. 2021 Mär 21;42(12):1170-1177. https://doi.org/10.1093/eurheartj/ehaa953

Bibtex

@article{06544f9fc13e411280b4974f610493e4,
title = "Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes",
abstract = "AIMS: There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts.METHODS AND RESULTS: In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11-1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF.CONCLUSIONS: In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention.",
keywords = "Alcohol Drinking/adverse effects, Atrial Fibrillation/epidemiology, Biomarkers, Cohort Studies, Female, Heart Failure/epidemiology, Humans, Incidence, Male, Middle Aged, Risk Assessment, Risk Factors",
author = "Dora Csengeri and Ngoc-Anh Spr{\"u}nker and {Di Castelnuovo}, Augusto and Teemu Niiranen and Vishram-Nielsen, {Julie Kk} and Simona Costanzo and Stefan S{\"o}derberg and Jensen, {Steen M} and Erkki Vartiainen and Donati, {Maria Benedetta} and Christina Magnussen and Stephan Camen and Francesco Gianfagna and Maja-Lisa L{\o}chen and Frank Kee and Jukka Kontto and Mathiesen, {Ellisiv B} and Wolfgang Koenig and Blankenberg Stefan and {de Gaetano}, Giovanni and Torben J{\o}rgensen and Kari Kuulasmaa and Tanja Zeller and Veikko Salomaa and Licia Iacoviello and Schnabel, {Renate B}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.",
year = "2021",
month = mar,
day = "21",
doi = "10.1093/eurheartj/ehaa953",
language = "English",
volume = "42",
pages = "1170--1177",
journal = "EUR HEART J",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes

AU - Csengeri, Dora

AU - Sprünker, Ngoc-Anh

AU - Di Castelnuovo, Augusto

AU - Niiranen, Teemu

AU - Vishram-Nielsen, Julie Kk

AU - Costanzo, Simona

AU - Söderberg, Stefan

AU - Jensen, Steen M

AU - Vartiainen, Erkki

AU - Donati, Maria Benedetta

AU - Magnussen, Christina

AU - Camen, Stephan

AU - Gianfagna, Francesco

AU - Løchen, Maja-Lisa

AU - Kee, Frank

AU - Kontto, Jukka

AU - Mathiesen, Ellisiv B

AU - Koenig, Wolfgang

AU - Stefan, Blankenberg

AU - de Gaetano, Giovanni

AU - Jørgensen, Torben

AU - Kuulasmaa, Kari

AU - Zeller, Tanja

AU - Salomaa, Veikko

AU - Iacoviello, Licia

AU - Schnabel, Renate B

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.

PY - 2021/3/21

Y1 - 2021/3/21

N2 - AIMS: There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts.METHODS AND RESULTS: In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11-1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF.CONCLUSIONS: In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention.

AB - AIMS: There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts.METHODS AND RESULTS: In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11-1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF.CONCLUSIONS: In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention.

KW - Alcohol Drinking/adverse effects

KW - Atrial Fibrillation/epidemiology

KW - Biomarkers

KW - Cohort Studies

KW - Female

KW - Heart Failure/epidemiology

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Risk Assessment

KW - Risk Factors

U2 - 10.1093/eurheartj/ehaa953

DO - 10.1093/eurheartj/ehaa953

M3 - SCORING: Journal article

C2 - 33438022

VL - 42

SP - 1170

EP - 1177

JO - EUR HEART J

JF - EUR HEART J

SN - 0195-668X

IS - 12

ER -