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Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction

Standard

Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. / Trembinski, D Julia; Bink, Diewertje I; Theodorou, Kosta; Sommer, Janina; Fischer, Ariane; van Bergen, Anke; Kuo, Chao-Chung; Costa, Ivan G; Schürmann, Christoph; Leisegang, Matthias S; Brandes, Ralf P; Alekseeva, Tijna; Brill, Boris; Wietelmann, Astrid; Johnson, Christopher N; Spring-Connell, Alexander; Kaulich, Manuel; Werfel, Stanislas; Engelhardt, Stefan; Hirt, Marc N; Yorgan, Kaja; Eschenhagen, Thomas; Kirchhof, Luisa; Hofmann, Patrick; Jaé, Nicolas; Wittig, Ilka; Hamdani, Nazha; Bischof, Corinne; Krishnan, Jaya; Houtkooper, Riekelt H; Dimmeler, Stefanie; Boon, Reinier A.

in: NAT COMMUN, Jahrgang 11, Nr. 1, 27.04.2020, S. 2039.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Trembinski, DJ, Bink, DI, Theodorou, K, Sommer, J, Fischer, A, van Bergen, A, Kuo, C-C, Costa, IG, Schürmann, C, Leisegang, MS, Brandes, RP, Alekseeva, T, Brill, B, Wietelmann, A, Johnson, CN, Spring-Connell, A, Kaulich, M, Werfel, S, Engelhardt, S, Hirt, MN, Yorgan, K, Eschenhagen, T, Kirchhof, L, Hofmann, P, Jaé, N, Wittig, I, Hamdani, N, Bischof, C, Krishnan, J, Houtkooper, RH, Dimmeler, S & Boon, RA 2020, 'Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction', NAT COMMUN, Jg. 11, Nr. 1, S. 2039. https://doi.org/10.1038/s41467-020-15995-2

APA

Trembinski, D. J., Bink, D. I., Theodorou, K., Sommer, J., Fischer, A., van Bergen, A., Kuo, C-C., Costa, I. G., Schürmann, C., Leisegang, M. S., Brandes, R. P., Alekseeva, T., Brill, B., Wietelmann, A., Johnson, C. N., Spring-Connell, A., Kaulich, M., Werfel, S., Engelhardt, S., ... Boon, R. A. (2020). Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. NAT COMMUN, 11(1), 2039. https://doi.org/10.1038/s41467-020-15995-2

Vancouver

Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A et al. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. NAT COMMUN. 2020 Apr 27;11(1):2039. https://doi.org/10.1038/s41467-020-15995-2

Bibtex

@article{b9adbdd554274b42bcd8ca89b95ae024,
title = "Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction",
abstract = "Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. Importantly, loss of SARRAH (OXCT1-AS1) in human engineered heart tissue results in impaired contractile force development. SARRAH directly binds to the promoters of genes downregulated after SARRAH silencing via RNA-DNA triple helix formation and cardiomyocytes lacking the triple helix forming domain of Sarrah show an increase in apoptosis. One of the direct SARRAH targets is NRF2, and restoration of NRF2 levels after SARRAH silencing partially rescues the reduction in cell viability. Overexpression of Sarrah in mice shows better recovery of cardiac contractile function after AMI compared to control mice. In summary, we identified the anti-apoptotic evolutionary conserved lncRNA Sarrah, which is downregulated by aging, as a regulator of cardiomyocyte survival.",
keywords = "Aging, Animals, Apoptosis, Carrier Proteins/genetics, Cell Survival, Coenzyme A-Transferases/genetics, Disease Models, Animal, Gene Silencing, Humans, LIM Domain Proteins/genetics, Male, Mice, Mice, Inbred C57BL, Myocardial Infarction/genetics, Myocytes, Cardiac/cytology, NF-E2-Related Factor 2/genetics, RNA, Antisense/genetics, RNA, Long Noncoding/genetics, RNA, Small Interfering/genetics, p300-CBP Transcription Factors/genetics",
author = "Trembinski, {D Julia} and Bink, {Diewertje I} and Kosta Theodorou and Janina Sommer and Ariane Fischer and {van Bergen}, Anke and Chao-Chung Kuo and Costa, {Ivan G} and Christoph Sch{\"u}rmann and Leisegang, {Matthias S} and Brandes, {Ralf P} and Tijna Alekseeva and Boris Brill and Astrid Wietelmann and Johnson, {Christopher N} and Alexander Spring-Connell and Manuel Kaulich and Stanislas Werfel and Stefan Engelhardt and Hirt, {Marc N} and Kaja Yorgan and Thomas Eschenhagen and Luisa Kirchhof and Patrick Hofmann and Nicolas Ja{\'e} and Ilka Wittig and Nazha Hamdani and Corinne Bischof and Jaya Krishnan and Houtkooper, {Riekelt H} and Stefanie Dimmeler and Boon, {Reinier A}",
year = "2020",
month = apr,
day = "27",
doi = "10.1038/s41467-020-15995-2",
language = "English",
volume = "11",
pages = "2039",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction

AU - Trembinski, D Julia

AU - Bink, Diewertje I

AU - Theodorou, Kosta

AU - Sommer, Janina

AU - Fischer, Ariane

AU - van Bergen, Anke

AU - Kuo, Chao-Chung

AU - Costa, Ivan G

AU - Schürmann, Christoph

AU - Leisegang, Matthias S

AU - Brandes, Ralf P

AU - Alekseeva, Tijna

AU - Brill, Boris

AU - Wietelmann, Astrid

AU - Johnson, Christopher N

AU - Spring-Connell, Alexander

AU - Kaulich, Manuel

AU - Werfel, Stanislas

AU - Engelhardt, Stefan

AU - Hirt, Marc N

AU - Yorgan, Kaja

AU - Eschenhagen, Thomas

AU - Kirchhof, Luisa

AU - Hofmann, Patrick

AU - Jaé, Nicolas

AU - Wittig, Ilka

AU - Hamdani, Nazha

AU - Bischof, Corinne

AU - Krishnan, Jaya

AU - Houtkooper, Riekelt H

AU - Dimmeler, Stefanie

AU - Boon, Reinier A

PY - 2020/4/27

Y1 - 2020/4/27

N2 - Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. Importantly, loss of SARRAH (OXCT1-AS1) in human engineered heart tissue results in impaired contractile force development. SARRAH directly binds to the promoters of genes downregulated after SARRAH silencing via RNA-DNA triple helix formation and cardiomyocytes lacking the triple helix forming domain of Sarrah show an increase in apoptosis. One of the direct SARRAH targets is NRF2, and restoration of NRF2 levels after SARRAH silencing partially rescues the reduction in cell viability. Overexpression of Sarrah in mice shows better recovery of cardiac contractile function after AMI compared to control mice. In summary, we identified the anti-apoptotic evolutionary conserved lncRNA Sarrah, which is downregulated by aging, as a regulator of cardiomyocyte survival.

AB - Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. Importantly, loss of SARRAH (OXCT1-AS1) in human engineered heart tissue results in impaired contractile force development. SARRAH directly binds to the promoters of genes downregulated after SARRAH silencing via RNA-DNA triple helix formation and cardiomyocytes lacking the triple helix forming domain of Sarrah show an increase in apoptosis. One of the direct SARRAH targets is NRF2, and restoration of NRF2 levels after SARRAH silencing partially rescues the reduction in cell viability. Overexpression of Sarrah in mice shows better recovery of cardiac contractile function after AMI compared to control mice. In summary, we identified the anti-apoptotic evolutionary conserved lncRNA Sarrah, which is downregulated by aging, as a regulator of cardiomyocyte survival.

KW - Aging

KW - Animals

KW - Apoptosis

KW - Carrier Proteins/genetics

KW - Cell Survival

KW - Coenzyme A-Transferases/genetics

KW - Disease Models, Animal

KW - Gene Silencing

KW - Humans

KW - LIM Domain Proteins/genetics

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Myocardial Infarction/genetics

KW - Myocytes, Cardiac/cytology

KW - NF-E2-Related Factor 2/genetics

KW - RNA, Antisense/genetics

KW - RNA, Long Noncoding/genetics

KW - RNA, Small Interfering/genetics

KW - p300-CBP Transcription Factors/genetics

U2 - 10.1038/s41467-020-15995-2

DO - 10.1038/s41467-020-15995-2

M3 - SCORING: Journal article

C2 - 32341350

VL - 11

SP - 2039

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -