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Aggravation of left ventricular dysfunction in patients with biopsy-proven cardiac human herpesvirus A and B infection

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Aggravation of left ventricular dysfunction in patients with biopsy-proven cardiac human herpesvirus A and B infection. / Escher, F; Kühl, U; Gross, U; Westermann, D; Poller, W; Tschöpe, C; Lassner, D; Schultheiss, H-P.

in: J CLIN VIROL, Jahrgang 63, 02.2015, S. 1-5.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Escher, F, Kühl, U, Gross, U, Westermann, D, Poller, W, Tschöpe, C, Lassner, D & Schultheiss, H-P 2015, 'Aggravation of left ventricular dysfunction in patients with biopsy-proven cardiac human herpesvirus A and B infection', J CLIN VIROL, Jg. 63, S. 1-5. https://doi.org/10.1016/j.jcv.2014.11.026

APA

Escher, F., Kühl, U., Gross, U., Westermann, D., Poller, W., Tschöpe, C., Lassner, D., & Schultheiss, H-P. (2015). Aggravation of left ventricular dysfunction in patients with biopsy-proven cardiac human herpesvirus A and B infection. J CLIN VIROL, 63, 1-5. https://doi.org/10.1016/j.jcv.2014.11.026

Vancouver

Escher F, Kühl U, Gross U, Westermann D, Poller W, Tschöpe C et al. Aggravation of left ventricular dysfunction in patients with biopsy-proven cardiac human herpesvirus A and B infection. J CLIN VIROL. 2015 Feb;63:1-5. https://doi.org/10.1016/j.jcv.2014.11.026

Bibtex

@article{29a800748e724de8b82522ba27fd1237,
title = "Aggravation of left ventricular dysfunction in patients with biopsy-proven cardiac human herpesvirus A and B infection",
abstract = "BACKGROUND: Human herpesvirus 6 (HHV-6) A and B are lymphotropic viruses with life-long persistence, primarily associated with non-cardiac diseases, and discussed as a possible etiologic factor of myocarditis and cardiomyopathy.OBJECTIVE: To analyze the long-term spontaneous course of cardiac patients suffering from suspected inflammatory cardiomyopathy (CMi) with persisting HHV-6 A and B infections by follow-up biopsies.STUDY DESIGN: We prospectively evaluated patients (n=73) with biopsy-proven viral HHV-6 A and B infection in endomyocardial biopsies (EMBs), followed up by reanalysis of EMBs and left ventricular ejection fraction (LV-EF) measurements after a median period of 8.8 months (range 4-73 months). Beyond, we studied HHV-6 prevalence in isolated peripheral blood cells (PBCs) and HHV-6 species in EMBs. HHV-6 species-specific cellular infection sites within the myocardium were identified by immunohistochemistry (IHC).RESULTS: We identified 73 patients with cardiac HHV-6 A and B persistence or newly detected in follow-up EMB (95.0% B). Proof of HHV-6 in PBCs was primarily associated with A. Persistence of cardiac HHV-6 B genome was significantly associated with cardiac dysfunction at follow-up (LV-EF deteriorated from 58.2±16.0 to 51.8±17.2%, p<0.001), and LV improvement was observed when HHV-6 B persistence resolved (LV-EF increased from 54.9±15.4 to 60.7±13.1%, p<0.001).CONCLUSIONS: Persistence of cardiac HHV-6 B genomes was significantly associated with cardiac dysfunction, and hemodynamic parameters improved in association with HHV-6 B clearance.",
keywords = "Adult, Aged, Biopsy, Blood/virology, Cardiomyopathies/pathology, Female, Heart/virology, Herpesvirus 6, Human/classification, Humans, Immunohistochemistry, Male, Middle Aged, Myocardium/pathology, Prospective Studies, Roseolovirus Infections/complications, Ventricular Dysfunction, Left/physiopathology",
author = "F Escher and U K{\"u}hl and U Gross and D Westermann and W Poller and C Tsch{\"o}pe and D Lassner and H-P Schultheiss",
note = "Copyright {\textcopyright} 2014 Elsevier B.V. All rights reserved.",
year = "2015",
month = feb,
doi = "10.1016/j.jcv.2014.11.026",
language = "English",
volume = "63",
pages = "1--5",
journal = "J CLIN VIROL",
issn = "1386-6532",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Aggravation of left ventricular dysfunction in patients with biopsy-proven cardiac human herpesvirus A and B infection

AU - Escher, F

AU - Kühl, U

AU - Gross, U

AU - Westermann, D

AU - Poller, W

AU - Tschöpe, C

AU - Lassner, D

AU - Schultheiss, H-P

N1 - Copyright © 2014 Elsevier B.V. All rights reserved.

PY - 2015/2

Y1 - 2015/2

N2 - BACKGROUND: Human herpesvirus 6 (HHV-6) A and B are lymphotropic viruses with life-long persistence, primarily associated with non-cardiac diseases, and discussed as a possible etiologic factor of myocarditis and cardiomyopathy.OBJECTIVE: To analyze the long-term spontaneous course of cardiac patients suffering from suspected inflammatory cardiomyopathy (CMi) with persisting HHV-6 A and B infections by follow-up biopsies.STUDY DESIGN: We prospectively evaluated patients (n=73) with biopsy-proven viral HHV-6 A and B infection in endomyocardial biopsies (EMBs), followed up by reanalysis of EMBs and left ventricular ejection fraction (LV-EF) measurements after a median period of 8.8 months (range 4-73 months). Beyond, we studied HHV-6 prevalence in isolated peripheral blood cells (PBCs) and HHV-6 species in EMBs. HHV-6 species-specific cellular infection sites within the myocardium were identified by immunohistochemistry (IHC).RESULTS: We identified 73 patients with cardiac HHV-6 A and B persistence or newly detected in follow-up EMB (95.0% B). Proof of HHV-6 in PBCs was primarily associated with A. Persistence of cardiac HHV-6 B genome was significantly associated with cardiac dysfunction at follow-up (LV-EF deteriorated from 58.2±16.0 to 51.8±17.2%, p<0.001), and LV improvement was observed when HHV-6 B persistence resolved (LV-EF increased from 54.9±15.4 to 60.7±13.1%, p<0.001).CONCLUSIONS: Persistence of cardiac HHV-6 B genomes was significantly associated with cardiac dysfunction, and hemodynamic parameters improved in association with HHV-6 B clearance.

AB - BACKGROUND: Human herpesvirus 6 (HHV-6) A and B are lymphotropic viruses with life-long persistence, primarily associated with non-cardiac diseases, and discussed as a possible etiologic factor of myocarditis and cardiomyopathy.OBJECTIVE: To analyze the long-term spontaneous course of cardiac patients suffering from suspected inflammatory cardiomyopathy (CMi) with persisting HHV-6 A and B infections by follow-up biopsies.STUDY DESIGN: We prospectively evaluated patients (n=73) with biopsy-proven viral HHV-6 A and B infection in endomyocardial biopsies (EMBs), followed up by reanalysis of EMBs and left ventricular ejection fraction (LV-EF) measurements after a median period of 8.8 months (range 4-73 months). Beyond, we studied HHV-6 prevalence in isolated peripheral blood cells (PBCs) and HHV-6 species in EMBs. HHV-6 species-specific cellular infection sites within the myocardium were identified by immunohistochemistry (IHC).RESULTS: We identified 73 patients with cardiac HHV-6 A and B persistence or newly detected in follow-up EMB (95.0% B). Proof of HHV-6 in PBCs was primarily associated with A. Persistence of cardiac HHV-6 B genome was significantly associated with cardiac dysfunction at follow-up (LV-EF deteriorated from 58.2±16.0 to 51.8±17.2%, p<0.001), and LV improvement was observed when HHV-6 B persistence resolved (LV-EF increased from 54.9±15.4 to 60.7±13.1%, p<0.001).CONCLUSIONS: Persistence of cardiac HHV-6 B genomes was significantly associated with cardiac dysfunction, and hemodynamic parameters improved in association with HHV-6 B clearance.

KW - Adult

KW - Aged

KW - Biopsy

KW - Blood/virology

KW - Cardiomyopathies/pathology

KW - Female

KW - Heart/virology

KW - Herpesvirus 6, Human/classification

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Middle Aged

KW - Myocardium/pathology

KW - Prospective Studies

KW - Roseolovirus Infections/complications

KW - Ventricular Dysfunction, Left/physiopathology

U2 - 10.1016/j.jcv.2014.11.026

DO - 10.1016/j.jcv.2014.11.026

M3 - SCORING: Journal article

C2 - 25600595

VL - 63

SP - 1

EP - 5

JO - J CLIN VIROL

JF - J CLIN VIROL

SN - 1386-6532

ER -