Age-Related Variations in Takotsubo Syndrome
Standard
Age-Related Variations in Takotsubo Syndrome. / Cammann, Victoria L; Szawan, Konrad A; Stähli, Barbara E; Kato, Ken; Budnik, Monika; Wischnewsky, Manfred; Dreiding, Sara; Levinson, Rena A; Di Vece, Davide; Gili, Sebastiano; Citro, Rodolfo; Bossone, Eduardo; Neuhaus, Michael; Franke, Jennifer; Meder, Benjamin; Jaguszewski, Miłosz; Noutsias, Michel; Knorr, Maike; Heiner, Susanne; D'Ascenzo, Fabrizio; Dichtl, Wolfgang; Burgdorf, Christof; Kherad, Behrouz; Tschöpe, Carsten; Sarcon, Annahita; Shinbane, Jerold; Rajan, Lawrence; Michels, Guido; Pfister, Roman; Cuneo, Alessandro; Jacobshagen, Claudius; Karakas, Mahir; Koenig, Wolfgang; Pott, Alexander; Meyer, Philippe; Roffi, Marco; Banning, Adrian; Wolfrum, Mathias; Cuculi, Florim; Kobza, Richard; Fischer, Thomas A; Vasankari, Tuija; Airaksinen, K E Juhani; Napp, L Christian; Dworakowski, Rafal; MacCarthy, Philip; Kaiser, Christoph; Osswald, Stefan; Galiuto, Leonarda; Chan, Christina; Bridgman, Paul; Beug, Daniel; Delmas, Clément; Lairez, Olivier; Gilyarova, Ekaterina; Shilova, Alexandra; Gilyarov, Mikhail; El-Battrawy, Ibrahim; Akin, Ibrahim; Poledniková, Karolina; Toušek, Petr; Winchester, David E; Galuszka, Jan; Ukena, Christian; Poglajen, Gregor; Carrilho-Ferreira, Pedro; Hauck, Christian; Paolini, Carla; Bilato, Claudio; Kobayashi, Yoshio; Shoji, Toshihiro; Ishibashi, Iwao; Takahara, Masayuki; Himi, Toshiharu; Din, Jehangir; Al-Shammari, Ali; Prasad, Abhiram; Rihal, Charanjit S; Liu, Kan; Schulze, P Christian; Bianco, Matteo; Jörg, Lucas; Rickli, Hans; Pestana, Gonçalo; Nguyen, Thanh H; Böhm, Michael; Maier, Lars S; Pinto, Fausto J; Widimský, Petr; Felix, Stephan B; Braun-Dullaeus, Ruediger C; Rottbauer, Wolfgang; Hasenfuß, Gerd; Pieske, Burkert M; Schunkert, Heribert; Borggrefe, Martin; Thiele, Holger; Bauersachs, Johann; Katus, Hugo A; Horowitz, John D; Di Mario, Carlo; Münzel, Thomas; Crea, Filippo; Bax, Jeroen J; Lüscher, Thomas F; Ruschitzka, Frank; Ghadri, Jelena R; Opolski, Grzegorz; Templin, Christian.
in: J AM COLL CARDIOL, Jahrgang 75, Nr. 16, 28.04.2020, S. 1869-1877.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Age-Related Variations in Takotsubo Syndrome
AU - Cammann, Victoria L
AU - Szawan, Konrad A
AU - Stähli, Barbara E
AU - Kato, Ken
AU - Budnik, Monika
AU - Wischnewsky, Manfred
AU - Dreiding, Sara
AU - Levinson, Rena A
AU - Di Vece, Davide
AU - Gili, Sebastiano
AU - Citro, Rodolfo
AU - Bossone, Eduardo
AU - Neuhaus, Michael
AU - Franke, Jennifer
AU - Meder, Benjamin
AU - Jaguszewski, Miłosz
AU - Noutsias, Michel
AU - Knorr, Maike
AU - Heiner, Susanne
AU - D'Ascenzo, Fabrizio
AU - Dichtl, Wolfgang
AU - Burgdorf, Christof
AU - Kherad, Behrouz
AU - Tschöpe, Carsten
AU - Sarcon, Annahita
AU - Shinbane, Jerold
AU - Rajan, Lawrence
AU - Michels, Guido
AU - Pfister, Roman
AU - Cuneo, Alessandro
AU - Jacobshagen, Claudius
AU - Karakas, Mahir
AU - Koenig, Wolfgang
AU - Pott, Alexander
AU - Meyer, Philippe
AU - Roffi, Marco
AU - Banning, Adrian
AU - Wolfrum, Mathias
AU - Cuculi, Florim
AU - Kobza, Richard
AU - Fischer, Thomas A
AU - Vasankari, Tuija
AU - Airaksinen, K E Juhani
AU - Napp, L Christian
AU - Dworakowski, Rafal
AU - MacCarthy, Philip
AU - Kaiser, Christoph
AU - Osswald, Stefan
AU - Galiuto, Leonarda
AU - Chan, Christina
AU - Bridgman, Paul
AU - Beug, Daniel
AU - Delmas, Clément
AU - Lairez, Olivier
AU - Gilyarova, Ekaterina
AU - Shilova, Alexandra
AU - Gilyarov, Mikhail
AU - El-Battrawy, Ibrahim
AU - Akin, Ibrahim
AU - Poledniková, Karolina
AU - Toušek, Petr
AU - Winchester, David E
AU - Galuszka, Jan
AU - Ukena, Christian
AU - Poglajen, Gregor
AU - Carrilho-Ferreira, Pedro
AU - Hauck, Christian
AU - Paolini, Carla
AU - Bilato, Claudio
AU - Kobayashi, Yoshio
AU - Shoji, Toshihiro
AU - Ishibashi, Iwao
AU - Takahara, Masayuki
AU - Himi, Toshiharu
AU - Din, Jehangir
AU - Al-Shammari, Ali
AU - Prasad, Abhiram
AU - Rihal, Charanjit S
AU - Liu, Kan
AU - Schulze, P Christian
AU - Bianco, Matteo
AU - Jörg, Lucas
AU - Rickli, Hans
AU - Pestana, Gonçalo
AU - Nguyen, Thanh H
AU - Böhm, Michael
AU - Maier, Lars S
AU - Pinto, Fausto J
AU - Widimský, Petr
AU - Felix, Stephan B
AU - Braun-Dullaeus, Ruediger C
AU - Rottbauer, Wolfgang
AU - Hasenfuß, Gerd
AU - Pieske, Burkert M
AU - Schunkert, Heribert
AU - Borggrefe, Martin
AU - Thiele, Holger
AU - Bauersachs, Johann
AU - Katus, Hugo A
AU - Horowitz, John D
AU - Di Mario, Carlo
AU - Münzel, Thomas
AU - Crea, Filippo
AU - Bax, Jeroen J
AU - Lüscher, Thomas F
AU - Ruschitzka, Frank
AU - Ghadri, Jelena R
AU - Opolski, Grzegorz
AU - Templin, Christian
N1 - Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
PY - 2020/4/28
Y1 - 2020/4/28
N2 - BACKGROUND: Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients.OBJECTIVES: This study aimed to investigate age-related differences in TTS.METHODS: Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: ≤50 years, middle-age: 51 to 74 years, elderly: ≥75 years). Baseline characteristics, hospital course, as well as short- and long-term mortality were compared among groups.RESULTS: Of 2,098 TTS patients, 242 (11.5%) patients were ≤50 years of age, 1,194 (56.9%) were 51 to 74 years of age, and 662 (31.6%) were ≥75 years of age. Younger patients were more often men (12.4% vs. 10.9% vs. 6.3%; p = 0.002) and had an increased prevalence of acute neurological (16.3% vs. 8.4% vs. 8.8%; p = 0.001) or psychiatric disorders (14.1% vs. 10.3% vs. 5.6%; p < 0.001) compared with middle-aged and elderly TTS patients. Furthermore, younger patients had more often cardiogenic shock (15.3% vs. 9.1% vs. 8.1%; p = 0.004) and had a numerically higher in-hospital mortality (6.6% vs. 3.6% vs. 5.1%; p = 0.07). At multivariable analysis, younger (odds ratio: 1.60; 95% confidence interval: 0.86 to 3.01; p = 0.14) and older age (odds ratio: 1.09; 95% confidence interval: 0.66 to 1.80; p = 0.75) were not independently associated with in-hospital mortality using the middle-aged group as a reference. There were no differences in 60-day mortality rates among groups.CONCLUSIONS: A substantial proportion of TTS patients are younger than 50 years of age. TTS is associated with severe complications requiring intensive care, particularly in younger patients.
AB - BACKGROUND: Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients.OBJECTIVES: This study aimed to investigate age-related differences in TTS.METHODS: Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: ≤50 years, middle-age: 51 to 74 years, elderly: ≥75 years). Baseline characteristics, hospital course, as well as short- and long-term mortality were compared among groups.RESULTS: Of 2,098 TTS patients, 242 (11.5%) patients were ≤50 years of age, 1,194 (56.9%) were 51 to 74 years of age, and 662 (31.6%) were ≥75 years of age. Younger patients were more often men (12.4% vs. 10.9% vs. 6.3%; p = 0.002) and had an increased prevalence of acute neurological (16.3% vs. 8.4% vs. 8.8%; p = 0.001) or psychiatric disorders (14.1% vs. 10.3% vs. 5.6%; p < 0.001) compared with middle-aged and elderly TTS patients. Furthermore, younger patients had more often cardiogenic shock (15.3% vs. 9.1% vs. 8.1%; p = 0.004) and had a numerically higher in-hospital mortality (6.6% vs. 3.6% vs. 5.1%; p = 0.07). At multivariable analysis, younger (odds ratio: 1.60; 95% confidence interval: 0.86 to 3.01; p = 0.14) and older age (odds ratio: 1.09; 95% confidence interval: 0.66 to 1.80; p = 0.75) were not independently associated with in-hospital mortality using the middle-aged group as a reference. There were no differences in 60-day mortality rates among groups.CONCLUSIONS: A substantial proportion of TTS patients are younger than 50 years of age. TTS is associated with severe complications requiring intensive care, particularly in younger patients.
KW - Age Factors
KW - Age of Onset
KW - Aged
KW - Causality
KW - Female
KW - Global Health
KW - Hospital Mortality
KW - Humans
KW - Male
KW - Mental Disorders/epidemiology
KW - Middle Aged
KW - Mortality
KW - Nervous System Diseases/epidemiology
KW - Prevalence
KW - Prognosis
KW - Registries
KW - Risk Assessment/statistics & numerical data
KW - Shock, Cardiogenic/epidemiology
KW - Takotsubo Cardiomyopathy/complications
U2 - 10.1016/j.jacc.2020.02.057
DO - 10.1016/j.jacc.2020.02.057
M3 - SCORING: Journal article
C2 - 32327096
VL - 75
SP - 1869
EP - 1877
JO - J AM COLL CARDIOL
JF - J AM COLL CARDIOL
SN - 0735-1097
IS - 16
ER -