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Age-Related Measurements of the Myelin Water Fraction derived from 3D multi-echo GRASE reflect Myelin Content of the Cerebral White Matter

Standard

Age-Related Measurements of the Myelin Water Fraction derived from 3D multi-echo GRASE reflect Myelin Content of the Cerebral White Matter. / Faizy, Tobias; Kumar, Dushyant; Broocks, Gabriel; Thaler, Christian; Flottmann, Fabian; Leischner, Hannes; Kutzner, Daniel; Hewera, Simon; Dotzauer, Dominik; Stellmann, Jan-Patrick; Reddy, Ravinder; Fiehler, Jens; Sedlacik, Jan; Gellißen, Susanne.

in: SCI REP-UK, Jahrgang 8, Nr. 1, 09.10.2018, S. 14991.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Faizy, T, Kumar, D, Broocks, G, Thaler, C, Flottmann, F, Leischner, H, Kutzner, D, Hewera, S, Dotzauer, D, Stellmann, J-P, Reddy, R, Fiehler, J, Sedlacik, J & Gellißen, S 2018, 'Age-Related Measurements of the Myelin Water Fraction derived from 3D multi-echo GRASE reflect Myelin Content of the Cerebral White Matter', SCI REP-UK, Jg. 8, Nr. 1, S. 14991. https://doi.org/10.1038/s41598-018-33112-8, https://doi.org/10.1038/s41598-018-33112-8

APA

Faizy, T., Kumar, D., Broocks, G., Thaler, C., Flottmann, F., Leischner, H., Kutzner, D., Hewera, S., Dotzauer, D., Stellmann, J-P., Reddy, R., Fiehler, J., Sedlacik, J., & Gellißen, S. (2018). Age-Related Measurements of the Myelin Water Fraction derived from 3D multi-echo GRASE reflect Myelin Content of the Cerebral White Matter. SCI REP-UK, 8(1), 14991. https://doi.org/10.1038/s41598-018-33112-8, https://doi.org/10.1038/s41598-018-33112-8

Vancouver

Faizy T, Kumar D, Broocks G, Thaler C, Flottmann F, Leischner H et al. Age-Related Measurements of the Myelin Water Fraction derived from 3D multi-echo GRASE reflect Myelin Content of the Cerebral White Matter. SCI REP-UK. 2018 Okt 9;8(1):14991. https://doi.org/10.1038/s41598-018-33112-8, https://doi.org/10.1038/s41598-018-33112-8

Bibtex

@article{440439cbafb44edb95f1ecf6a881da1c,
title = "Age-Related Measurements of the Myelin Water Fraction derived from 3D multi-echo GRASE reflect Myelin Content of the Cerebral White Matter",
abstract = "Myelin Water Fraction (MWF) measurements derived from quantitative Myelin Water Imaging (MWI) may detect demyelinating changes of the cerebral white matter (WM) microstructure. Here, we investigated age-related alterations of the MWF in normal aging brains of healthy volunteers utilizing two fast and clinically feasible 3D gradient and spin echo (GRASE) MWI sequences with 3 mm and 5 mm isotropic voxel size. In 45 healthy subjects (age range: 18-79 years), distinct regions of interest (ROI) were defined in the cerebral WM including corticospinal tracts. For the 3 mm sequence, significant correlations of the mean MWF with age were found for most ROIs (r < -0.8 for WM ROIs; r = -0.55 for splenium of corpus callosum; r = -0.75 for genu of corpus callosum; p < 0.001 for all ROIs). Similar correlations with age were found for the ROIs of the 5 mm sequence. No significant correlations were found for the corticospinal tract and the occipital WM (p > 0.05). Mean MWF values obtained from the 3 mm and 5 mm sequences were strongly comparable. The applied 3D GRASE MWI sequences were found to be sensitive for age-dependent myelin changes of the cerebral WM microstructure. The reported MWF values might be of substantial use as reference for further investigations in patient studies.",
keywords = "Adolescent, Adult, Aged, Corpus Callosum/diagnostic imaging, Demyelinating Diseases/diagnostic imaging, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Myelin Sheath/metabolism, Water/chemistry, White Matter/diagnostic imaging, Young Adult",
author = "Tobias Faizy and Dushyant Kumar and Gabriel Broocks and Christian Thaler and Fabian Flottmann and Hannes Leischner and Daniel Kutzner and Simon Hewera and Dominik Dotzauer and Jan-Patrick Stellmann and Ravinder Reddy and Jens Fiehler and Jan Sedlacik and Susanne Gelli{\ss}en",
year = "2018",
month = oct,
day = "9",
doi = "https://doi.org/10.1038/s41598-018-33112-8",
language = "English",
volume = "8",
pages = "14991",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Age-Related Measurements of the Myelin Water Fraction derived from 3D multi-echo GRASE reflect Myelin Content of the Cerebral White Matter

AU - Faizy, Tobias

AU - Kumar, Dushyant

AU - Broocks, Gabriel

AU - Thaler, Christian

AU - Flottmann, Fabian

AU - Leischner, Hannes

AU - Kutzner, Daniel

AU - Hewera, Simon

AU - Dotzauer, Dominik

AU - Stellmann, Jan-Patrick

AU - Reddy, Ravinder

AU - Fiehler, Jens

AU - Sedlacik, Jan

AU - Gellißen, Susanne

PY - 2018/10/9

Y1 - 2018/10/9

N2 - Myelin Water Fraction (MWF) measurements derived from quantitative Myelin Water Imaging (MWI) may detect demyelinating changes of the cerebral white matter (WM) microstructure. Here, we investigated age-related alterations of the MWF in normal aging brains of healthy volunteers utilizing two fast and clinically feasible 3D gradient and spin echo (GRASE) MWI sequences with 3 mm and 5 mm isotropic voxel size. In 45 healthy subjects (age range: 18-79 years), distinct regions of interest (ROI) were defined in the cerebral WM including corticospinal tracts. For the 3 mm sequence, significant correlations of the mean MWF with age were found for most ROIs (r < -0.8 for WM ROIs; r = -0.55 for splenium of corpus callosum; r = -0.75 for genu of corpus callosum; p < 0.001 for all ROIs). Similar correlations with age were found for the ROIs of the 5 mm sequence. No significant correlations were found for the corticospinal tract and the occipital WM (p > 0.05). Mean MWF values obtained from the 3 mm and 5 mm sequences were strongly comparable. The applied 3D GRASE MWI sequences were found to be sensitive for age-dependent myelin changes of the cerebral WM microstructure. The reported MWF values might be of substantial use as reference for further investigations in patient studies.

AB - Myelin Water Fraction (MWF) measurements derived from quantitative Myelin Water Imaging (MWI) may detect demyelinating changes of the cerebral white matter (WM) microstructure. Here, we investigated age-related alterations of the MWF in normal aging brains of healthy volunteers utilizing two fast and clinically feasible 3D gradient and spin echo (GRASE) MWI sequences with 3 mm and 5 mm isotropic voxel size. In 45 healthy subjects (age range: 18-79 years), distinct regions of interest (ROI) were defined in the cerebral WM including corticospinal tracts. For the 3 mm sequence, significant correlations of the mean MWF with age were found for most ROIs (r < -0.8 for WM ROIs; r = -0.55 for splenium of corpus callosum; r = -0.75 for genu of corpus callosum; p < 0.001 for all ROIs). Similar correlations with age were found for the ROIs of the 5 mm sequence. No significant correlations were found for the corticospinal tract and the occipital WM (p > 0.05). Mean MWF values obtained from the 3 mm and 5 mm sequences were strongly comparable. The applied 3D GRASE MWI sequences were found to be sensitive for age-dependent myelin changes of the cerebral WM microstructure. The reported MWF values might be of substantial use as reference for further investigations in patient studies.

KW - Adolescent

KW - Adult

KW - Aged

KW - Corpus Callosum/diagnostic imaging

KW - Demyelinating Diseases/diagnostic imaging

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Myelin Sheath/metabolism

KW - Water/chemistry

KW - White Matter/diagnostic imaging

KW - Young Adult

U2 - https://doi.org/10.1038/s41598-018-33112-8

DO - https://doi.org/10.1038/s41598-018-33112-8

M3 - SCORING: Journal article

C2 - 30301904

VL - 8

SP - 14991

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -