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Age-related distribution of vertebral bone-marrow diffusivity

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Age-related distribution of vertebral bone-marrow diffusivity. / Herrmann, Jochen; Krstin, Nina; Schoennagel, Bjoern P; Sornsakrin, Marjike; Derlin, Thorsten; Busch, Jasmin D; Petersen, Kay Uwe; Graessner, Joachim; Adam, Gerhard; Habermann, Christian R.

in: EUR J RADIOL, Jahrgang 81, Nr. 12, 12, 01.12.2012, S. 4046-9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Herrmann, J, Krstin, N, Schoennagel, BP, Sornsakrin, M, Derlin, T, Busch, JD, Petersen, KU, Graessner, J, Adam, G & Habermann, CR 2012, 'Age-related distribution of vertebral bone-marrow diffusivity', EUR J RADIOL, Jg. 81, Nr. 12, 12, S. 4046-9. https://doi.org/10.1016/j.ejrad.2012.03.033

APA

Herrmann, J., Krstin, N., Schoennagel, B. P., Sornsakrin, M., Derlin, T., Busch, J. D., Petersen, K. U., Graessner, J., Adam, G., & Habermann, C. R. (2012). Age-related distribution of vertebral bone-marrow diffusivity. EUR J RADIOL, 81(12), 4046-9. [12]. https://doi.org/10.1016/j.ejrad.2012.03.033

Vancouver

Herrmann J, Krstin N, Schoennagel BP, Sornsakrin M, Derlin T, Busch JD et al. Age-related distribution of vertebral bone-marrow diffusivity. EUR J RADIOL. 2012 Dez 1;81(12):4046-9. 12. https://doi.org/10.1016/j.ejrad.2012.03.033

Bibtex

@article{a9918b639931457e84d526f49de1d580,
title = "Age-related distribution of vertebral bone-marrow diffusivity",
abstract = "PURPOSE: To determine age-related diffusivity changes of the lumbar bone marrow by measurement of apparent diffusion coefficient (ADC) values.MATERIALS AND METHODS: The local ethics committee approved this study and written informed consent was obtained. The study group comprised 88 individuals including 75 healthy volunteers and 13 patients (48 female, 40 male; mean age 36 years, range 0-84 years). The pediatric cases were recruited from patients. Echo-planar diffusion weighted imaging (DWI) was performed with b-values of 50, 400 and 800 s/mm(2). ADC-values were calculated and measured in the 1st and 2nd vertebral body of the lumbar spine. Correlation between age and ADC-values was analyzed with Spearman's rho test.RESULTS: The ADC values of the vertebral bone marrow of the lumbar spine showed a significant negative correlation with age (rho=-0.398, p=0.001). The mean ADC values (×10(-3)mm(2)/s) in the age groups 0-29 years (mean age 18.0 years, n=42) and 30-88 years (mean age 51.6 years, n=46) were 0.54 ± 0.07 and 0.47 ± 0.08, respectively (p<0.001, T-test). No significant differences were found between children and young adults.CONCLUSION: Bone marrow ADC values of the lumbar spine show a linear decrease with growing age and thereby reflect the gradual changes of cell composition occurring during marrow conversion.",
keywords = "Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Adolescent, Young Adult, Child, Reproducibility of Results, Sensitivity and Specificity, Child, Preschool, Infant, Infant, Newborn, Diffusion Magnetic Resonance Imaging/*methods, Bone Marrow/*pathology, Image Interpretation, Computer-Assisted/*methods, Aging/*pathology, Lumbar Vertebrae/*cytology, Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Adolescent, Young Adult, Child, Reproducibility of Results, Sensitivity and Specificity, Child, Preschool, Infant, Infant, Newborn, Diffusion Magnetic Resonance Imaging/*methods, Bone Marrow/*pathology, Image Interpretation, Computer-Assisted/*methods, Aging/*pathology, Lumbar Vertebrae/*cytology",
author = "Jochen Herrmann and Nina Krstin and Schoennagel, {Bjoern P} and Marjike Sornsakrin and Thorsten Derlin and Busch, {Jasmin D} and Petersen, {Kay Uwe} and Joachim Graessner and Gerhard Adam and Habermann, {Christian R}",
note = "Copyright {\textcopyright} 2012 Elsevier Ireland Ltd. All rights reserved.",
year = "2012",
month = dec,
day = "1",
doi = "10.1016/j.ejrad.2012.03.033",
language = "English",
volume = "81",
pages = "4046--9",
journal = "EUR J RADIOL",
issn = "0720-048X",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - Age-related distribution of vertebral bone-marrow diffusivity

AU - Herrmann, Jochen

AU - Krstin, Nina

AU - Schoennagel, Bjoern P

AU - Sornsakrin, Marjike

AU - Derlin, Thorsten

AU - Busch, Jasmin D

AU - Petersen, Kay Uwe

AU - Graessner, Joachim

AU - Adam, Gerhard

AU - Habermann, Christian R

N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - PURPOSE: To determine age-related diffusivity changes of the lumbar bone marrow by measurement of apparent diffusion coefficient (ADC) values.MATERIALS AND METHODS: The local ethics committee approved this study and written informed consent was obtained. The study group comprised 88 individuals including 75 healthy volunteers and 13 patients (48 female, 40 male; mean age 36 years, range 0-84 years). The pediatric cases were recruited from patients. Echo-planar diffusion weighted imaging (DWI) was performed with b-values of 50, 400 and 800 s/mm(2). ADC-values were calculated and measured in the 1st and 2nd vertebral body of the lumbar spine. Correlation between age and ADC-values was analyzed with Spearman's rho test.RESULTS: The ADC values of the vertebral bone marrow of the lumbar spine showed a significant negative correlation with age (rho=-0.398, p=0.001). The mean ADC values (×10(-3)mm(2)/s) in the age groups 0-29 years (mean age 18.0 years, n=42) and 30-88 years (mean age 51.6 years, n=46) were 0.54 ± 0.07 and 0.47 ± 0.08, respectively (p<0.001, T-test). No significant differences were found between children and young adults.CONCLUSION: Bone marrow ADC values of the lumbar spine show a linear decrease with growing age and thereby reflect the gradual changes of cell composition occurring during marrow conversion.

AB - PURPOSE: To determine age-related diffusivity changes of the lumbar bone marrow by measurement of apparent diffusion coefficient (ADC) values.MATERIALS AND METHODS: The local ethics committee approved this study and written informed consent was obtained. The study group comprised 88 individuals including 75 healthy volunteers and 13 patients (48 female, 40 male; mean age 36 years, range 0-84 years). The pediatric cases were recruited from patients. Echo-planar diffusion weighted imaging (DWI) was performed with b-values of 50, 400 and 800 s/mm(2). ADC-values were calculated and measured in the 1st and 2nd vertebral body of the lumbar spine. Correlation between age and ADC-values was analyzed with Spearman's rho test.RESULTS: The ADC values of the vertebral bone marrow of the lumbar spine showed a significant negative correlation with age (rho=-0.398, p=0.001). The mean ADC values (×10(-3)mm(2)/s) in the age groups 0-29 years (mean age 18.0 years, n=42) and 30-88 years (mean age 51.6 years, n=46) were 0.54 ± 0.07 and 0.47 ± 0.08, respectively (p<0.001, T-test). No significant differences were found between children and young adults.CONCLUSION: Bone marrow ADC values of the lumbar spine show a linear decrease with growing age and thereby reflect the gradual changes of cell composition occurring during marrow conversion.

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Adolescent

KW - Young Adult

KW - Child

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Child, Preschool

KW - Infant

KW - Infant, Newborn

KW - Diffusion Magnetic Resonance Imaging/methods

KW - Bone Marrow/pathology

KW - Image Interpretation, Computer-Assisted/methods

KW - Aging/pathology

KW - Lumbar Vertebrae/cytology

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Adolescent

KW - Young Adult

KW - Child

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Child, Preschool

KW - Infant

KW - Infant, Newborn

KW - Diffusion Magnetic Resonance Imaging/methods

KW - Bone Marrow/pathology

KW - Image Interpretation, Computer-Assisted/methods

KW - Aging/pathology

KW - Lumbar Vertebrae/cytology

U2 - 10.1016/j.ejrad.2012.03.033

DO - 10.1016/j.ejrad.2012.03.033

M3 - SCORING: Journal article

C2 - 23017195

VL - 81

SP - 4046

EP - 4049

JO - EUR J RADIOL

JF - EUR J RADIOL

SN - 0720-048X

IS - 12

M1 - 12

ER -