Age-related changes of the human brain: Insight from double-wave vector imaging
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Age-related changes of the human brain: Insight from double-wave vector imaging. / Lawrenz, Marco; Finsterbusch, Jürgen; Brassen, Stefanie.
ISMRM 23rd Annual Meeting & Exhibition: Toronto. 2015. S. 0724.Publikationen: SCORING: Beitrag in Buch/Sammelwerk › Konferenzbeitrag - Aufsatz in Konferenzband › Forschung › Begutachtung
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TY - CHAP
T1 - Age-related changes of the human brain: Insight from double-wave vector imaging
AU - Lawrenz, Marco
AU - Finsterbusch, Jürgen
AU - Brassen, Stefanie
PY - 2015
Y1 - 2015
N2 - Double wave-vector (DWV) or d-PFG experiments with two diffusion weighting periods applied successively in a single acquisition offer access to microscopic tissue properties. With a short mixing time τm between the two diffusion weightings, the experiment can be used to determine cell or compartment sizes, for a long τm diffusion anisotropy present on a microscopic scale can be investigated. For instance, even in a white matter (WM) region-of-interest (ROI) that appeared isotropic in a DTI experiment, i.e. has a fractional anisotropy (FA) equal to 0, anisotropic diffusion could be detected demonstrating the additional information that DWV can provide compared to DTI. Recent studies showed that a measure of the microscopic diffusion anisotropy, the MA index, can be determined in the living human brain, and normal values and their variation in a group of young (< 33 y), healthy volunteers have been reported. In this study, DWV and DTI measurements were performed in a group of old (> 60 y), healthy volunteers. Their MA and FA values were determined and compared to those reported for young volunteers in order to investigate age-related changes of the diffusion anisotropy.
AB - Double wave-vector (DWV) or d-PFG experiments with two diffusion weighting periods applied successively in a single acquisition offer access to microscopic tissue properties. With a short mixing time τm between the two diffusion weightings, the experiment can be used to determine cell or compartment sizes, for a long τm diffusion anisotropy present on a microscopic scale can be investigated. For instance, even in a white matter (WM) region-of-interest (ROI) that appeared isotropic in a DTI experiment, i.e. has a fractional anisotropy (FA) equal to 0, anisotropic diffusion could be detected demonstrating the additional information that DWV can provide compared to DTI. Recent studies showed that a measure of the microscopic diffusion anisotropy, the MA index, can be determined in the living human brain, and normal values and their variation in a group of young (< 33 y), healthy volunteers have been reported. In this study, DWV and DTI measurements were performed in a group of old (> 60 y), healthy volunteers. Their MA and FA values were determined and compared to those reported for young volunteers in order to investigate age-related changes of the diffusion anisotropy.
M3 - Conference contribution - Article for conference
SP - 0724
BT - ISMRM 23rd Annual Meeting & Exhibition
T2 - ISMRM 23rd Annual Meeting & Exhibition
Y2 - 1 January 1800
ER -