Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons.
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Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons. / Braak, Heiko; Thal, Dietmar Rudolf; Matschke, Jakob; Ghebremedhin, Estifanos; Kelly, Del Tredici.
in: NEUROBIOL AGING, Jahrgang 34, Nr. 1, 1, 2013, S. 286-297.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons.
AU - Braak, Heiko
AU - Thal, Dietmar Rudolf
AU - Matschke, Jakob
AU - Ghebremedhin, Estifanos
AU - Kelly, Del Tredici
PY - 2013
Y1 - 2013
N2 - We identified p62-immunoreactive inclusions in dendrites of catecholaminergic brainstem projection neurons using antibodies against p62, ubiquitin, ?-synuclein, hyperphosphorylated tau, and tyrosine hydroxylase in 100-?m sections through the brainstem dorsal vagal area, locus coeruleus, and substantia nigra of 149 autopsy cases staged for intraneuronal Alzheimer's and Parkinson's disease-associated lesions. The inclusions resembled Marinesco bodies within cell nuclei of catecholaminergic neurons as well as the dot-like structures previously described by Dickson in specific neuropil areas in humans. The p62-positive inclusions were confined to dendrites of catecholaminergic neurons, lacked neuromelanin granules, and were tau- and ?-synuclein-negative. Their immunoreactivity for ubiquitin varied and their prevalence significantly increased with advancing age. The presence or absence of Alzheimer's and/or Parkinson's disease-associated pathology did not influence their existence. There was a strong association between the presence of p62-positive inclusions and Marinesco bodies (p < 0.0001). Our results reveal a hitherto unknown alteration within specific neuronal types of the human brainstem that may be independent of the sequestosome-ubiquitin-proteasomal pathway and unrelated to proteinaceous aggregate-formation of neurodegenerative diseases.
AB - We identified p62-immunoreactive inclusions in dendrites of catecholaminergic brainstem projection neurons using antibodies against p62, ubiquitin, ?-synuclein, hyperphosphorylated tau, and tyrosine hydroxylase in 100-?m sections through the brainstem dorsal vagal area, locus coeruleus, and substantia nigra of 149 autopsy cases staged for intraneuronal Alzheimer's and Parkinson's disease-associated lesions. The inclusions resembled Marinesco bodies within cell nuclei of catecholaminergic neurons as well as the dot-like structures previously described by Dickson in specific neuropil areas in humans. The p62-positive inclusions were confined to dendrites of catecholaminergic neurons, lacked neuromelanin granules, and were tau- and ?-synuclein-negative. Their immunoreactivity for ubiquitin varied and their prevalence significantly increased with advancing age. The presence or absence of Alzheimer's and/or Parkinson's disease-associated pathology did not influence their existence. There was a strong association between the presence of p62-positive inclusions and Marinesco bodies (p < 0.0001). Our results reveal a hitherto unknown alteration within specific neuronal types of the human brainstem that may be independent of the sequestosome-ubiquitin-proteasomal pathway and unrelated to proteinaceous aggregate-formation of neurodegenerative diseases.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Adolescent
KW - Young Adult
KW - Child
KW - Aging
KW - Dendrites/physiology
KW - RNA-Binding Proteins/metabolism
KW - Brain Stem/cytology
KW - Catecholamines/metabolism
KW - Inclusion Bodies/physiology
KW - Neurons/cytology/metabolism
KW - alpha-Synuclein/metabolism
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Adolescent
KW - Young Adult
KW - Child
KW - Aging
KW - Dendrites/physiology
KW - RNA-Binding Proteins/metabolism
KW - Brain Stem/cytology
KW - Catecholamines/metabolism
KW - Inclusion Bodies/physiology
KW - Neurons/cytology/metabolism
KW - alpha-Synuclein/metabolism
M3 - SCORING: Journal article
VL - 34
SP - 286
EP - 297
JO - NEUROBIOL AGING
JF - NEUROBIOL AGING
SN - 0197-4580
IS - 1
M1 - 1
ER -
