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Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension

Standard

Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension. / Rejdak, Robert; Kohler, Konrad; Kocki, Tomasz; Shenk, Yana; Turski, Waldemar A; Okuno, Etsuo; Lehaci, Cristiana; Zagorski, Zbigniew; Zrenner, Eberhart; Schuettauf, Frank.

in: VISION RES, Jahrgang 44, Nr. 7, 03.2004, S. 655-60.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rejdak, R, Kohler, K, Kocki, T, Shenk, Y, Turski, WA, Okuno, E, Lehaci, C, Zagorski, Z, Zrenner, E & Schuettauf, F 2004, 'Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension', VISION RES, Jg. 44, Nr. 7, S. 655-60. https://doi.org/10.1016/j.visres.2003.11.003

APA

Rejdak, R., Kohler, K., Kocki, T., Shenk, Y., Turski, W. A., Okuno, E., Lehaci, C., Zagorski, Z., Zrenner, E., & Schuettauf, F. (2004). Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension. VISION RES, 44(7), 655-60. https://doi.org/10.1016/j.visres.2003.11.003

Vancouver

Rejdak R, Kohler K, Kocki T, Shenk Y, Turski WA, Okuno E et al. Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension. VISION RES. 2004 Mär;44(7):655-60. https://doi.org/10.1016/j.visres.2003.11.003

Bibtex

@article{f6ec5582068745088225e8f5b87a4373,
title = "Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension",
abstract = "The study examines age-dependent changes of kynurenic acid (KYNA) content and kynurenine aminotransferases (KAT I and KAT II) celluar expression in the retinas of DBA/2J mice. Retinas were obtained from DBA/2J mice of different ages (3, 6 and 11 months). C57BL6 mice were used as controls. As measured with HPLC, KYNA content decreased (p < 0.01) in the retinas of 6-month-old DBA/2J mice and continued to decrease (p < 0.0074) in the retinas of 11-month-old animals compared to the controls. Immunohistochemistry showed that expression of both KAT I and KAT II decreased markedly in the retinas of 11-month-old DBA/2J mice compared to controls. The impairment in KYNA biosynthesis in the retinas of DBA/2J mice may be one of the mechanisms of retinal neurodegeneration related to ocular hypertension.",
keywords = "Aging/physiology, Animals, Chromatography, High Pressure Liquid, Female, Immunohistochemistry/methods, Kynurenic Acid/analysis, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Models, Animal, Ocular Hypertension/metabolism, Retina/metabolism, Transaminases/analysis",
author = "Robert Rejdak and Konrad Kohler and Tomasz Kocki and Yana Shenk and Turski, {Waldemar A} and Etsuo Okuno and Cristiana Lehaci and Zbigniew Zagorski and Eberhart Zrenner and Frank Schuettauf",
year = "2004",
month = mar,
doi = "10.1016/j.visres.2003.11.003",
language = "English",
volume = "44",
pages = "655--60",
journal = "VISION RES",
issn = "0042-6989",
publisher = "Elsevier Limited",
number = "7",

}

RIS

TY - JOUR

T1 - Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension

AU - Rejdak, Robert

AU - Kohler, Konrad

AU - Kocki, Tomasz

AU - Shenk, Yana

AU - Turski, Waldemar A

AU - Okuno, Etsuo

AU - Lehaci, Cristiana

AU - Zagorski, Zbigniew

AU - Zrenner, Eberhart

AU - Schuettauf, Frank

PY - 2004/3

Y1 - 2004/3

N2 - The study examines age-dependent changes of kynurenic acid (KYNA) content and kynurenine aminotransferases (KAT I and KAT II) celluar expression in the retinas of DBA/2J mice. Retinas were obtained from DBA/2J mice of different ages (3, 6 and 11 months). C57BL6 mice were used as controls. As measured with HPLC, KYNA content decreased (p < 0.01) in the retinas of 6-month-old DBA/2J mice and continued to decrease (p < 0.0074) in the retinas of 11-month-old animals compared to the controls. Immunohistochemistry showed that expression of both KAT I and KAT II decreased markedly in the retinas of 11-month-old DBA/2J mice compared to controls. The impairment in KYNA biosynthesis in the retinas of DBA/2J mice may be one of the mechanisms of retinal neurodegeneration related to ocular hypertension.

AB - The study examines age-dependent changes of kynurenic acid (KYNA) content and kynurenine aminotransferases (KAT I and KAT II) celluar expression in the retinas of DBA/2J mice. Retinas were obtained from DBA/2J mice of different ages (3, 6 and 11 months). C57BL6 mice were used as controls. As measured with HPLC, KYNA content decreased (p < 0.01) in the retinas of 6-month-old DBA/2J mice and continued to decrease (p < 0.0074) in the retinas of 11-month-old animals compared to the controls. Immunohistochemistry showed that expression of both KAT I and KAT II decreased markedly in the retinas of 11-month-old DBA/2J mice compared to controls. The impairment in KYNA biosynthesis in the retinas of DBA/2J mice may be one of the mechanisms of retinal neurodegeneration related to ocular hypertension.

KW - Aging/physiology

KW - Animals

KW - Chromatography, High Pressure Liquid

KW - Female

KW - Immunohistochemistry/methods

KW - Kynurenic Acid/analysis

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Inbred DBA

KW - Models, Animal

KW - Ocular Hypertension/metabolism

KW - Retina/metabolism

KW - Transaminases/analysis

U2 - 10.1016/j.visres.2003.11.003

DO - 10.1016/j.visres.2003.11.003

M3 - SCORING: Journal article

C2 - 14751550

VL - 44

SP - 655

EP - 660

JO - VISION RES

JF - VISION RES

SN - 0042-6989

IS - 7

ER -