PortalPublikationenAge, treatment and prognosis of patients with squamous cell ...

Age, treatment and prognosis of patients with squamous cell vulvar cancer (VSCC) - analysis of the AGO-CaRE-1 study

Standard

Age, treatment and prognosis of patients with squamous cell vulvar cancer (VSCC) - analysis of the AGO-CaRE-1 study. / Prieske, Katharina; Woelber, Linn; Muallem, Mustafa Zelal; Eulenburg, Christine; Jueckstock, Julia Kathrin; Hilpert, Felix; de Gregorio, Nikolaus; Iborra, Severine; Ignatov, Atanas; Hillemanns, Peter; Fuerst, Sophie; Strauss, Hans-Georg; Baumann, Klaus; Beckmann, Matthias; Mustea, Alexander; Meier, Werner; Harter, Philipp; Wimberger, Pauline; Sehouli, Jalid; Mahner, Sven.

in: GYNECOL ONCOL, Jahrgang 161, Nr. 2, 05.2021, S. 442-448.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Prieske, K, Woelber, L, Muallem, MZ, Eulenburg, C, Jueckstock, JK, Hilpert, F, de Gregorio, N, Iborra, S, Ignatov, A, Hillemanns, P, Fuerst, S, Strauss, H-G, Baumann, K, Beckmann, M, Mustea, A, Meier, W, Harter, P, Wimberger, P, Sehouli, J & Mahner, S 2021, 'Age, treatment and prognosis of patients with squamous cell vulvar cancer (VSCC) - analysis of the AGO-CaRE-1 study', GYNECOL ONCOL, Jg. 161, Nr. 2, S. 442-448. https://doi.org/10.1016/j.ygyno.2021.02.025

APA

Prieske, K., Woelber, L., Muallem, M. Z., Eulenburg, C., Jueckstock, J. K., Hilpert, F., de Gregorio, N., Iborra, S., Ignatov, A., Hillemanns, P., Fuerst, S., Strauss, H-G., Baumann, K., Beckmann, M., Mustea, A., Meier, W., Harter, P., Wimberger, P., Sehouli, J., & Mahner, S. (2021). Age, treatment and prognosis of patients with squamous cell vulvar cancer (VSCC) - analysis of the AGO-CaRE-1 study. GYNECOL ONCOL, 161(2), 442-448. https://doi.org/10.1016/j.ygyno.2021.02.025

Vancouver

Prieske K, Woelber L, Muallem MZ, Eulenburg C, Jueckstock JK, Hilpert F et al. Age, treatment and prognosis of patients with squamous cell vulvar cancer (VSCC) - analysis of the AGO-CaRE-1 study. GYNECOL ONCOL. 2021 Mai;161(2):442-448. https://doi.org/10.1016/j.ygyno.2021.02.025

Bibtex

@article{b2627229ea5c4c709dd700586835771c,
title = "Age, treatment and prognosis of patients with squamous cell vulvar cancer (VSCC) - analysis of the AGO-CaRE-1 study",
abstract = "BACKGROUND: Despite an increasing incidence with simultaneous decreasing age of onset, vulvar squamous cell carcinoma (VSCC) is still a disease that mainly effects the elderly population. Data on the association of age with prognosis and treatment patterns in VSCC are sparse.METHODS: This is an analysis of the AGO-CaRE-1 cohort. Patients with VSCC (FIGO stage ≥1B), treated at 29 cancer centers in Germany from 1998 to 2008, were included in a centralized database (n = 1618). In this subgroup analysis patients were analyzed according to age [<50 yrs. (n = 220), 50-69 yrs. (n = 506), ≥70 yrs. (n = 521)] with regard to treatment patterns and prognosis. Only patients with documented age, surgical groin staging and known nodal status were included (n = 1247). Median follow-up was 27.5 months.RESULTS: At first diagnosis, women ≥70 yrs. presented with more advanced tumor stages (<0.001), larger tumor diameter (<0.001), poorer ECOG status (<0.001), more frequent HPV negative tumors (p = 0.03) as well as a higher rate of nodal involvement (<0.001). Disease recurrence occurred significantly more often in elderly patients (p = 0.001) and age as well as ECOG status, microscopic residual resection, tumor stage, grading, and (chemo)radiation were independent prognostic factors for death or recurrence in multivariate analysis. 2-year disease-free survival rates were 59.3% (≥70 yrs), 65.8% (50-69 yrs) and 81.1% (<50 yrs), respectively (p < 0.001).CONCLUSIONS: Older women with VSCC present with advanced tumor stages at first diagnosis and have an increased risk of recurrence as well as a decreased 2-year DFS in comparison to younger patients. Potential reasons could be self-awareness and/or more aggressive tumor biology due to HPV independent disease.",
author = "Katharina Prieske and Linn Woelber and Muallem, {Mustafa Zelal} and Christine Eulenburg and Jueckstock, {Julia Kathrin} and Felix Hilpert and {de Gregorio}, Nikolaus and Severine Iborra and Atanas Ignatov and Peter Hillemanns and Sophie Fuerst and Hans-Georg Strauss and Klaus Baumann and Matthias Beckmann and Alexander Mustea and Werner Meier and Philipp Harter and Pauline Wimberger and Jalid Sehouli and Sven Mahner",
note = "Copyright {\textcopyright} 2021. Published by Elsevier Inc.",
year = "2021",
month = may,
doi = "10.1016/j.ygyno.2021.02.025",
language = "English",
volume = "161",
pages = "442--448",
journal = "GYNECOL ONCOL",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Age, treatment and prognosis of patients with squamous cell vulvar cancer (VSCC) - analysis of the AGO-CaRE-1 study

AU - Prieske, Katharina

AU - Woelber, Linn

AU - Muallem, Mustafa Zelal

AU - Eulenburg, Christine

AU - Jueckstock, Julia Kathrin

AU - Hilpert, Felix

AU - de Gregorio, Nikolaus

AU - Iborra, Severine

AU - Ignatov, Atanas

AU - Hillemanns, Peter

AU - Fuerst, Sophie

AU - Strauss, Hans-Georg

AU - Baumann, Klaus

AU - Beckmann, Matthias

AU - Mustea, Alexander

AU - Meier, Werner

AU - Harter, Philipp

AU - Wimberger, Pauline

AU - Sehouli, Jalid

AU - Mahner, Sven

N1 - Copyright © 2021. Published by Elsevier Inc.

PY - 2021/5

Y1 - 2021/5

N2 - BACKGROUND: Despite an increasing incidence with simultaneous decreasing age of onset, vulvar squamous cell carcinoma (VSCC) is still a disease that mainly effects the elderly population. Data on the association of age with prognosis and treatment patterns in VSCC are sparse.METHODS: This is an analysis of the AGO-CaRE-1 cohort. Patients with VSCC (FIGO stage ≥1B), treated at 29 cancer centers in Germany from 1998 to 2008, were included in a centralized database (n = 1618). In this subgroup analysis patients were analyzed according to age [<50 yrs. (n = 220), 50-69 yrs. (n = 506), ≥70 yrs. (n = 521)] with regard to treatment patterns and prognosis. Only patients with documented age, surgical groin staging and known nodal status were included (n = 1247). Median follow-up was 27.5 months.RESULTS: At first diagnosis, women ≥70 yrs. presented with more advanced tumor stages (<0.001), larger tumor diameter (<0.001), poorer ECOG status (<0.001), more frequent HPV negative tumors (p = 0.03) as well as a higher rate of nodal involvement (<0.001). Disease recurrence occurred significantly more often in elderly patients (p = 0.001) and age as well as ECOG status, microscopic residual resection, tumor stage, grading, and (chemo)radiation were independent prognostic factors for death or recurrence in multivariate analysis. 2-year disease-free survival rates were 59.3% (≥70 yrs), 65.8% (50-69 yrs) and 81.1% (<50 yrs), respectively (p < 0.001).CONCLUSIONS: Older women with VSCC present with advanced tumor stages at first diagnosis and have an increased risk of recurrence as well as a decreased 2-year DFS in comparison to younger patients. Potential reasons could be self-awareness and/or more aggressive tumor biology due to HPV independent disease.

AB - BACKGROUND: Despite an increasing incidence with simultaneous decreasing age of onset, vulvar squamous cell carcinoma (VSCC) is still a disease that mainly effects the elderly population. Data on the association of age with prognosis and treatment patterns in VSCC are sparse.METHODS: This is an analysis of the AGO-CaRE-1 cohort. Patients with VSCC (FIGO stage ≥1B), treated at 29 cancer centers in Germany from 1998 to 2008, were included in a centralized database (n = 1618). In this subgroup analysis patients were analyzed according to age [<50 yrs. (n = 220), 50-69 yrs. (n = 506), ≥70 yrs. (n = 521)] with regard to treatment patterns and prognosis. Only patients with documented age, surgical groin staging and known nodal status were included (n = 1247). Median follow-up was 27.5 months.RESULTS: At first diagnosis, women ≥70 yrs. presented with more advanced tumor stages (<0.001), larger tumor diameter (<0.001), poorer ECOG status (<0.001), more frequent HPV negative tumors (p = 0.03) as well as a higher rate of nodal involvement (<0.001). Disease recurrence occurred significantly more often in elderly patients (p = 0.001) and age as well as ECOG status, microscopic residual resection, tumor stage, grading, and (chemo)radiation were independent prognostic factors for death or recurrence in multivariate analysis. 2-year disease-free survival rates were 59.3% (≥70 yrs), 65.8% (50-69 yrs) and 81.1% (<50 yrs), respectively (p < 0.001).CONCLUSIONS: Older women with VSCC present with advanced tumor stages at first diagnosis and have an increased risk of recurrence as well as a decreased 2-year DFS in comparison to younger patients. Potential reasons could be self-awareness and/or more aggressive tumor biology due to HPV independent disease.

U2 - 10.1016/j.ygyno.2021.02.025

DO - 10.1016/j.ygyno.2021.02.025

M3 - SCORING: Journal article

C2 - 33648748

VL - 161

SP - 442

EP - 448

JO - GYNECOL ONCOL

JF - GYNECOL ONCOL

SN - 0090-8258

IS - 2

ER -