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Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings

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Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings. / Rossi, Giuseppe; Salmanton-García, Jon; Marchesi, Francesco; Dávila-Valls, Julio; Martín-Pérez, Sonia; Itri, Federico; López-García, Alberto; Glenthøj, Andreas; Gomes da Silva, Maria; Besson, Caroline; Marchetti, Monia; Weinbergerová, Barbora; Jaksic, Ozren; Jiménez, Moraima; Bilgin, Yavuz M; Van Doesum, Jaap; Farina, Francesca; Žák, Pavel; Verga, Luisa; Collins, Graham P; Bonuomo, Valentina; Van Praet, Jens; Nucci, Marcio; Meers, Stef; Espigado, Ildefonso; Fracchiolla, Nicola S; Valković, Toni; Poulsen, Christian Bjørn; Čolović, Natasha; Dragonetti, Giulia; Ledoux, Marie-Pierre; Tascini, Carlo; Buquicchio, Caterina; Blennow, Ola; Passamonti, Francesco; Machado, Marina; Labrador, Jorge; Duarte, Rafael F; Schönlein, Martin; Prezioso, Lucia; Falces-Romero, Iker; Kulasekararaj, Austin; Garcia-Vidal, Carolina; Fernández, Noemí; Abu-Zeinah, Ghaith; Ormazabal-Vélez, Irati; Adžić-Vukičević, Tatjana; Piukovics, Klára; Stoma, Igor; Cuccaro, Annarosa; Magliano, Gabriele; Szotkowski, Tomáš; González-López, Tomás-José; El-Ashwah, Shaimaa; Bergantim, Rui; Sili, Uluhan; Maertens, Johan; Demirkan, Fatih; De Ramón, Cristina; Petzer, Verena; Del Principe, Maria Ilaria; Navrátil, Milan; Dargenio, Michelina; Seval, Guldane Cengiz; Samarkos, Michail; Ráčil, Zdeněk; Pinczés, László Imre; Lahmer, Tobias; Busca, Alessandro; Méndez, Gustavo-Adolfo; Vena, Antonio; Biernat, Monika M; Merelli, Maria; Calbacho, Maria; Barać, Aleksandra; Bavastro, Martina; Limongelli, Alessandro; Ilhan, Osman; Wolf, Dominik; Çolak, Gökçe Melis; García-Sanz, Ramón; Emarah, Ziad; Mišković, Bojana; Gräfe, Stefanie K; Mladenović, Miloš; Aiello, Tommaso Francesco; Núñez-Martín-Buitrago, Lucía; Nordlander, Anna; Arellano, Elena; Zambrotta, Giovanni Paolo Maria; Ammatuna, Emanuele; Cabirta, Alba; Sacchi, Maria Vittoria; Nunes Rodrigues, Raquel; Hersby, Ditte Stampe; Hanakova, Michaela; Rahimli, Laman; Cordoba, Raul; Cornely, Oliver A; Pagano, Livio; Collaborators.

in: INT J INFECT DIS, Jahrgang 137, 12.2023, S. 98-110.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rossi, G, Salmanton-García, J, Marchesi, F, Dávila-Valls, J, Martín-Pérez, S, Itri, F, López-García, A, Glenthøj, A, Gomes da Silva, M, Besson, C, Marchetti, M, Weinbergerová, B, Jaksic, O, Jiménez, M, Bilgin, YM, Van Doesum, J, Farina, F, Žák, P, Verga, L, Collins, GP, Bonuomo, V, Van Praet, J, Nucci, M, Meers, S, Espigado, I, Fracchiolla, NS, Valković, T, Poulsen, CB, Čolović, N, Dragonetti, G, Ledoux, M-P, Tascini, C, Buquicchio, C, Blennow, O, Passamonti, F, Machado, M, Labrador, J, Duarte, RF, Schönlein, M, Prezioso, L, Falces-Romero, I, Kulasekararaj, A, Garcia-Vidal, C, Fernández, N, Abu-Zeinah, G, Ormazabal-Vélez, I, Adžić-Vukičević, T, Piukovics, K, Stoma, I, Cuccaro, A, Magliano, G, Szotkowski, T, González-López, T-J, El-Ashwah, S, Bergantim, R, Sili, U, Maertens, J, Demirkan, F, De Ramón, C, Petzer, V, Del Principe, MI, Navrátil, M, Dargenio, M, Seval, GC, Samarkos, M, Ráčil, Z, Pinczés, LI, Lahmer, T, Busca, A, Méndez, G-A, Vena, A, Biernat, MM, Merelli, M, Calbacho, M, Barać, A, Bavastro, M, Limongelli, A, Ilhan, O, Wolf, D, Çolak, GM, García-Sanz, R, Emarah, Z, Mišković, B, Gräfe, SK, Mladenović, M, Aiello, TF, Núñez-Martín-Buitrago, L, Nordlander, A, Arellano, E, Zambrotta, GPM, Ammatuna, E, Cabirta, A, Sacchi, MV, Nunes Rodrigues, R, Hersby, DS, Hanakova, M, Rahimli, L, Cordoba, R, Cornely, OA, Pagano, L & Collaborators 2023, 'Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings', INT J INFECT DIS, Jg. 137, S. 98-110. https://doi.org/10.1016/j.ijid.2023.10.013

APA

Rossi, G., Salmanton-García, J., Marchesi, F., Dávila-Valls, J., Martín-Pérez, S., Itri, F., López-García, A., Glenthøj, A., Gomes da Silva, M., Besson, C., Marchetti, M., Weinbergerová, B., Jaksic, O., Jiménez, M., Bilgin, Y. M., Van Doesum, J., Farina, F., Žák, P., Verga, L., ... Collaborators (2023). Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings. INT J INFECT DIS, 137, 98-110. https://doi.org/10.1016/j.ijid.2023.10.013

Vancouver

Rossi G, Salmanton-García J, Marchesi F, Dávila-Valls J, Martín-Pérez S, Itri F et al. Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings. INT J INFECT DIS. 2023 Dez;137:98-110. https://doi.org/10.1016/j.ijid.2023.10.013

Bibtex

@article{92eb8811fdc4459fa91f03df2a74ece9,
title = "Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings",
abstract = "OBJECTIVES: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail.METHODS: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy.RESULTS: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment.CONCLUSION: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.",
keywords = "Aged, Humans, Male, Aged, 80 and over, Female, COVID-19, Vaccination, Immunization, Lymphopenia, Hematologic Neoplasms/complications",
author = "Giuseppe Rossi and Jon Salmanton-Garc{\'i}a and Francesco Marchesi and Julio D{\'a}vila-Valls and Sonia Mart{\'i}n-P{\'e}rez and Federico Itri and Alberto L{\'o}pez-Garc{\'i}a and Andreas Glenth{\o}j and {Gomes da Silva}, Maria and Caroline Besson and Monia Marchetti and Barbora Weinbergerov{\'a} and Ozren Jaksic and Moraima Jim{\'e}nez and Bilgin, {Yavuz M} and {Van Doesum}, Jaap and Francesca Farina and Pavel {\v Z}{\'a}k and Luisa Verga and Collins, {Graham P} and Valentina Bonuomo and {Van Praet}, Jens and Marcio Nucci and Stef Meers and Ildefonso Espigado and Fracchiolla, {Nicola S} and Toni Valkovi{\'c} and Poulsen, {Christian Bj{\o}rn} and Natasha {\v C}olovi{\'c} and Giulia Dragonetti and Marie-Pierre Ledoux and Carlo Tascini and Caterina Buquicchio and Ola Blennow and Francesco Passamonti and Marina Machado and Jorge Labrador and Duarte, {Rafael F} and Martin Sch{\"o}nlein and Lucia Prezioso and Iker Falces-Romero and Austin Kulasekararaj and Carolina Garcia-Vidal and Noem{\'i} Fern{\'a}ndez and Ghaith Abu-Zeinah and Irati Ormazabal-V{\'e}lez and Tatjana Ad{\v z}i{\'c}-Vuki{\v c}evi{\'c} and Kl{\'a}ra Piukovics and Igor Stoma and Annarosa Cuccaro and Gabriele Magliano and Tom{\'a}{\v s} Szotkowski and Tom{\'a}s-Jos{\'e} Gonz{\'a}lez-L{\'o}pez and Shaimaa El-Ashwah and Rui Bergantim and Uluhan Sili and Johan Maertens and Fatih Demirkan and {De Ram{\'o}n}, Cristina and Verena Petzer and {Del Principe}, {Maria Ilaria} and Milan Navr{\'a}til and Michelina Dargenio and Seval, {Guldane Cengiz} and Michail Samarkos and Zden{\v e}k R{\'a}{\v c}il and Pincz{\'e}s, {L{\'a}szl{\'o} Imre} and Tobias Lahmer and Alessandro Busca and Gustavo-Adolfo M{\'e}ndez and Antonio Vena and Biernat, {Monika M} and Maria Merelli and Maria Calbacho and Aleksandra Bara{\'c} and Martina Bavastro and Alessandro Limongelli and Osman Ilhan and Dominik Wolf and {\c C}olak, {G{\"o}k{\c c}e Melis} and Ram{\'o}n Garc{\'i}a-Sanz and Ziad Emarah and Bojana Mi{\v s}kovi{\'c} and Gr{\"a}fe, {Stefanie K} and Milo{\v s} Mladenovi{\'c} and Aiello, {Tommaso Francesco} and Luc{\'i}a N{\'u}{\~n}ez-Mart{\'i}n-Buitrago and Anna Nordlander and Elena Arellano and Zambrotta, {Giovanni Paolo Maria} and Emanuele Ammatuna and Alba Cabirta and Sacchi, {Maria Vittoria} and {Nunes Rodrigues}, Raquel and Hersby, {Ditte Stampe} and Michaela Hanakova and Laman Rahimli and Raul Cordoba and Cornely, {Oliver A} and Livio Pagano and Collaborators",
note = "Copyright {\textcopyright} 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.",
year = "2023",
month = dec,
doi = "10.1016/j.ijid.2023.10.013",
language = "English",
volume = "137",
pages = "98--110",
journal = "INT J INFECT DIS",
issn = "1201-9712",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings

AU - Rossi, Giuseppe

AU - Salmanton-García, Jon

AU - Marchesi, Francesco

AU - Dávila-Valls, Julio

AU - Martín-Pérez, Sonia

AU - Itri, Federico

AU - López-García, Alberto

AU - Glenthøj, Andreas

AU - Gomes da Silva, Maria

AU - Besson, Caroline

AU - Marchetti, Monia

AU - Weinbergerová, Barbora

AU - Jaksic, Ozren

AU - Jiménez, Moraima

AU - Bilgin, Yavuz M

AU - Van Doesum, Jaap

AU - Farina, Francesca

AU - Žák, Pavel

AU - Verga, Luisa

AU - Collins, Graham P

AU - Bonuomo, Valentina

AU - Van Praet, Jens

AU - Nucci, Marcio

AU - Meers, Stef

AU - Espigado, Ildefonso

AU - Fracchiolla, Nicola S

AU - Valković, Toni

AU - Poulsen, Christian Bjørn

AU - Čolović, Natasha

AU - Dragonetti, Giulia

AU - Ledoux, Marie-Pierre

AU - Tascini, Carlo

AU - Buquicchio, Caterina

AU - Blennow, Ola

AU - Passamonti, Francesco

AU - Machado, Marina

AU - Labrador, Jorge

AU - Duarte, Rafael F

AU - Schönlein, Martin

AU - Prezioso, Lucia

AU - Falces-Romero, Iker

AU - Kulasekararaj, Austin

AU - Garcia-Vidal, Carolina

AU - Fernández, Noemí

AU - Abu-Zeinah, Ghaith

AU - Ormazabal-Vélez, Irati

AU - Adžić-Vukičević, Tatjana

AU - Piukovics, Klára

AU - Stoma, Igor

AU - Cuccaro, Annarosa

AU - Magliano, Gabriele

AU - Szotkowski, Tomáš

AU - González-López, Tomás-José

AU - El-Ashwah, Shaimaa

AU - Bergantim, Rui

AU - Sili, Uluhan

AU - Maertens, Johan

AU - Demirkan, Fatih

AU - De Ramón, Cristina

AU - Petzer, Verena

AU - Del Principe, Maria Ilaria

AU - Navrátil, Milan

AU - Dargenio, Michelina

AU - Seval, Guldane Cengiz

AU - Samarkos, Michail

AU - Ráčil, Zdeněk

AU - Pinczés, László Imre

AU - Lahmer, Tobias

AU - Busca, Alessandro

AU - Méndez, Gustavo-Adolfo

AU - Vena, Antonio

AU - Biernat, Monika M

AU - Merelli, Maria

AU - Calbacho, Maria

AU - Barać, Aleksandra

AU - Bavastro, Martina

AU - Limongelli, Alessandro

AU - Ilhan, Osman

AU - Wolf, Dominik

AU - Çolak, Gökçe Melis

AU - García-Sanz, Ramón

AU - Emarah, Ziad

AU - Mišković, Bojana

AU - Gräfe, Stefanie K

AU - Mladenović, Miloš

AU - Aiello, Tommaso Francesco

AU - Núñez-Martín-Buitrago, Lucía

AU - Nordlander, Anna

AU - Arellano, Elena

AU - Zambrotta, Giovanni Paolo Maria

AU - Ammatuna, Emanuele

AU - Cabirta, Alba

AU - Sacchi, Maria Vittoria

AU - Nunes Rodrigues, Raquel

AU - Hersby, Ditte Stampe

AU - Hanakova, Michaela

AU - Rahimli, Laman

AU - Cordoba, Raul

AU - Cornely, Oliver A

AU - Pagano, Livio

AU - Collaborators

N1 - Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

PY - 2023/12

Y1 - 2023/12

N2 - OBJECTIVES: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail.METHODS: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy.RESULTS: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment.CONCLUSION: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.

AB - OBJECTIVES: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail.METHODS: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy.RESULTS: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment.CONCLUSION: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.

KW - Aged

KW - Humans

KW - Male

KW - Aged, 80 and over

KW - Female

KW - COVID-19

KW - Vaccination

KW - Immunization

KW - Lymphopenia

KW - Hematologic Neoplasms/complications

U2 - 10.1016/j.ijid.2023.10.013

DO - 10.1016/j.ijid.2023.10.013

M3 - SCORING: Journal article

C2 - 37863310

VL - 137

SP - 98

EP - 110

JO - INT J INFECT DIS

JF - INT J INFECT DIS

SN - 1201-9712

ER -