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Aetiology of mitral regurgitation differentially affects 2-year adverse outcomes after MitraClip therapy in high-risk patients

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Aetiology of mitral regurgitation differentially affects 2-year adverse outcomes after MitraClip therapy in high-risk patients. / Rudolph, Volker; Lubos, Edith; Schlüter, Michael; Lubs, Daniel; Goldmann, Britta; Knap, Malgorzata; de Vries, Tjark; Treede, Hendrik; Schirmer, Johannes; Conradi, Lenard; Wegscheider, Karl; Reichenspurner, Hermann; Blankenberg, Stefan; Baldus, Stephan.

in: EUR J HEART FAIL, Jahrgang 15, Nr. 7, 07.2013, S. 796-807.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung

Harvard

Rudolph, V, Lubos, E, Schlüter, M, Lubs, D, Goldmann, B, Knap, M, de Vries, T, Treede, H, Schirmer, J, Conradi, L, Wegscheider, K, Reichenspurner, H, Blankenberg, S & Baldus, S 2013, 'Aetiology of mitral regurgitation differentially affects 2-year adverse outcomes after MitraClip therapy in high-risk patients', EUR J HEART FAIL, Jg. 15, Nr. 7, S. 796-807. https://doi.org/10.1093/eurjhf/hft021

APA

Rudolph, V., Lubos, E., Schlüter, M., Lubs, D., Goldmann, B., Knap, M., de Vries, T., Treede, H., Schirmer, J., Conradi, L., Wegscheider, K., Reichenspurner, H., Blankenberg, S., & Baldus, S. (2013). Aetiology of mitral regurgitation differentially affects 2-year adverse outcomes after MitraClip therapy in high-risk patients. EUR J HEART FAIL, 15(7), 796-807. https://doi.org/10.1093/eurjhf/hft021

Vancouver

Rudolph V, Lubos E, Schlüter M, Lubs D, Goldmann B, Knap M et al. Aetiology of mitral regurgitation differentially affects 2-year adverse outcomes after MitraClip therapy in high-risk patients. EUR J HEART FAIL. 2013 Jul;15(7):796-807. https://doi.org/10.1093/eurjhf/hft021

Bibtex

@article{7e4a184dd7f846e49bc813ca29bf35ae,
title = "Aetiology of mitral regurgitation differentially affects 2-year adverse outcomes after MitraClip therapy in high-risk patients",
abstract = "AIMS: To assess, and identify predictors of 2-year adverse outcomes of surgical high-risk patients after successful MitraClip therapy (MC), differentiated by the aetiology of mitral regurgitation (MR).METHODS AND RESULTS: Kaplan-Meier analysis was used to assess survival free from death, heart failure rehospitalization, and reintervention up to 2 years in 202 successfully treated patients [74 ± 9 years, 132 men (65%); secondary MR aetiology in 140 patients, primary MR in 62]. Predictors for study endpoints were determined using Cox regression analyses. Mortality was 20% at 1 year and 33% at 2 years in both primary and secondary MR patients; independent predictors of death were reduced forward stroke volume, impaired LV function, and renal failure in primary MR, yet only an increased logistic EuroSCORE in functional MR patients. The rate of rehospitalizations was not different between the patient subgroups for 6 months, but then diverged significantly in favour of primary MR patients (estimated 2-year incidence, primary MR 40% vs. secondary MR 66%). No predictor was found for primary MR patients, but increased LV end-diastolic volume significantly increased the risk of rehospitalization in functional MR patients. Reinterventions were overall rare (7.4% at 1 year, 9.7% at 2 years); primary MR patients required all except one reintervention within 2 months of MC, with again no predictors found, whereas secondary MR patients (all except one with discharge MR of 2+) exhibited a steadily declining freedom from reintervention curve throughout follow-up.CONCLUSION: MR aetiology affects rehospitalization and reintervention, but not mortality, differently after successful MC.",
keywords = "Aged, Echocardiography, Female, Follow-Up Studies, Germany/epidemiology, Heart Failure/complications, Heart Valve Prosthesis Implantation/adverse effects, Humans, Kaplan-Meier Estimate, Magnetic Resonance Imaging, Cine, Male, Mitral Valve/surgery, Mitral Valve Insufficiency/etiology, Prognosis, Retrospective Studies, Risk Factors, Severity of Illness Index, Survival Rate/trends, Time Factors, Treatment Outcome",
author = "Volker Rudolph and Edith Lubos and Michael Schl{\"u}ter and Daniel Lubs and Britta Goldmann and Malgorzata Knap and {de Vries}, Tjark and Hendrik Treede and Johannes Schirmer and Lenard Conradi and Karl Wegscheider and Hermann Reichenspurner and Stefan Blankenberg and Stephan Baldus",
year = "2013",
month = jul,
doi = "10.1093/eurjhf/hft021",
language = "English",
volume = "15",
pages = "796--807",
journal = "EUR J HEART FAIL",
issn = "1388-9842",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Aetiology of mitral regurgitation differentially affects 2-year adverse outcomes after MitraClip therapy in high-risk patients

AU - Rudolph, Volker

AU - Lubos, Edith

AU - Schlüter, Michael

AU - Lubs, Daniel

AU - Goldmann, Britta

AU - Knap, Malgorzata

AU - de Vries, Tjark

AU - Treede, Hendrik

AU - Schirmer, Johannes

AU - Conradi, Lenard

AU - Wegscheider, Karl

AU - Reichenspurner, Hermann

AU - Blankenberg, Stefan

AU - Baldus, Stephan

PY - 2013/7

Y1 - 2013/7

N2 - AIMS: To assess, and identify predictors of 2-year adverse outcomes of surgical high-risk patients after successful MitraClip therapy (MC), differentiated by the aetiology of mitral regurgitation (MR).METHODS AND RESULTS: Kaplan-Meier analysis was used to assess survival free from death, heart failure rehospitalization, and reintervention up to 2 years in 202 successfully treated patients [74 ± 9 years, 132 men (65%); secondary MR aetiology in 140 patients, primary MR in 62]. Predictors for study endpoints were determined using Cox regression analyses. Mortality was 20% at 1 year and 33% at 2 years in both primary and secondary MR patients; independent predictors of death were reduced forward stroke volume, impaired LV function, and renal failure in primary MR, yet only an increased logistic EuroSCORE in functional MR patients. The rate of rehospitalizations was not different between the patient subgroups for 6 months, but then diverged significantly in favour of primary MR patients (estimated 2-year incidence, primary MR 40% vs. secondary MR 66%). No predictor was found for primary MR patients, but increased LV end-diastolic volume significantly increased the risk of rehospitalization in functional MR patients. Reinterventions were overall rare (7.4% at 1 year, 9.7% at 2 years); primary MR patients required all except one reintervention within 2 months of MC, with again no predictors found, whereas secondary MR patients (all except one with discharge MR of 2+) exhibited a steadily declining freedom from reintervention curve throughout follow-up.CONCLUSION: MR aetiology affects rehospitalization and reintervention, but not mortality, differently after successful MC.

AB - AIMS: To assess, and identify predictors of 2-year adverse outcomes of surgical high-risk patients after successful MitraClip therapy (MC), differentiated by the aetiology of mitral regurgitation (MR).METHODS AND RESULTS: Kaplan-Meier analysis was used to assess survival free from death, heart failure rehospitalization, and reintervention up to 2 years in 202 successfully treated patients [74 ± 9 years, 132 men (65%); secondary MR aetiology in 140 patients, primary MR in 62]. Predictors for study endpoints were determined using Cox regression analyses. Mortality was 20% at 1 year and 33% at 2 years in both primary and secondary MR patients; independent predictors of death were reduced forward stroke volume, impaired LV function, and renal failure in primary MR, yet only an increased logistic EuroSCORE in functional MR patients. The rate of rehospitalizations was not different between the patient subgroups for 6 months, but then diverged significantly in favour of primary MR patients (estimated 2-year incidence, primary MR 40% vs. secondary MR 66%). No predictor was found for primary MR patients, but increased LV end-diastolic volume significantly increased the risk of rehospitalization in functional MR patients. Reinterventions were overall rare (7.4% at 1 year, 9.7% at 2 years); primary MR patients required all except one reintervention within 2 months of MC, with again no predictors found, whereas secondary MR patients (all except one with discharge MR of 2+) exhibited a steadily declining freedom from reintervention curve throughout follow-up.CONCLUSION: MR aetiology affects rehospitalization and reintervention, but not mortality, differently after successful MC.

KW - Aged

KW - Echocardiography

KW - Female

KW - Follow-Up Studies

KW - Germany/epidemiology

KW - Heart Failure/complications

KW - Heart Valve Prosthesis Implantation/adverse effects

KW - Humans

KW - Kaplan-Meier Estimate

KW - Magnetic Resonance Imaging, Cine

KW - Male

KW - Mitral Valve/surgery

KW - Mitral Valve Insufficiency/etiology

KW - Prognosis

KW - Retrospective Studies

KW - Risk Factors

KW - Severity of Illness Index

KW - Survival Rate/trends

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1093/eurjhf/hft021

DO - 10.1093/eurjhf/hft021

M3 - SCORING: Journal article

C2 - 23426023

VL - 15

SP - 796

EP - 807

JO - EUR J HEART FAIL

JF - EUR J HEART FAIL

SN - 1388-9842

IS - 7

ER -