Advancing knowledge of right ventricular pathophysiology in chronic pressure overload: Insights from experimental studies

Julien Guihaire; Pierre Emmanuel Noly; Sonja Schrepfer; Olaf Mercier

doi:10.1016/j.acvd.2015.05.008

Advancing knowledge of right ventricular pathophysiology in chronic pressure overload: Insights from experimental studies

Standard

Advancing knowledge of right ventricular pathophysiology in chronic pressure overload: Insights from experimental studies. / Guihaire, Julien; Noly, Pierre Emmanuel; Schrepfer, Sonja; Mercier, Olaf.

in: ARCH CARDIOVASC DIS, Jahrgang 108, Nr. 10, 10.2015, S. 519-529.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Guihaire, J, Noly, PE, Schrepfer, S & Mercier, O 2015, 'Advancing knowledge of right ventricular pathophysiology in chronic pressure overload: Insights from experimental studies', ARCH CARDIOVASC DIS, Jg. 108, Nr. 10, S. 519-529. https://doi.org/10.1016/j.acvd.2015.05.008

APA

Guihaire, J., Noly, P. E., Schrepfer, S., & Mercier, O. (2015). Advancing knowledge of right ventricular pathophysiology in chronic pressure overload: Insights from experimental studies. ARCH CARDIOVASC DIS, 108(10), 519-529. https://doi.org/10.1016/j.acvd.2015.05.008

Vancouver

Guihaire J, Noly PE, Schrepfer S, Mercier O. Advancing knowledge of right ventricular pathophysiology in chronic pressure overload: Insights from experimental studies. ARCH CARDIOVASC DIS. 2015 Okt;108(10):519-529. https://doi.org/10.1016/j.acvd.2015.05.008

Bibtex

@article{cbf311564e334671904b94e1dcbb949e,

title = "Advancing knowledge of right ventricular pathophysiology in chronic pressure overload: Insights from experimental studies",

abstract = "The right ventricle (RV) has to face major changes in loading conditions due to cardiovascular diseases and pulmonary vascular disorders. Clinical experience supports evidence that the RV better compensates for volume than for pressure overload, and for chronic than for acute changes. For a long time, right ventricular (RV) pathophysiology has been restricted to patterns extrapolated from left heart studies. However, the two ventricles are anatomically, haemodynamically and functionally distinct. RV metabolic properties may also result in a different behaviour in response to pathological conditions compared with the left ventricle. In this review, current knowledge of RV pathophysiology is reported in the setting of chronic pressure overload, including recent experimental findings and emerging concepts. After a time-varying compensated period with preserved cardiac output despite overload conditions, RV failure finally occurs, leading to death. The underlying mechanisms involved in the transition from compensatory hypertrophy to maladaptive remodelling are not completely understood. ",

keywords = "Animals, Blood Pressure, Cardiac Output, Chronic Disease, Humans, Hypertension/complications, Hypertrophy, Right Ventricular/etiology, Pulmonary Circulation, Risk Factors, Treatment Outcome, Ventricular Dysfunction, Right/diagnosis, Ventricular Function, Right, Ventricular Remodeling",

author = "Julien Guihaire and Noly, {Pierre Emmanuel} and Sonja Schrepfer and Olaf Mercier",

year = "2015",

month = oct,

doi = "10.1016/j.acvd.2015.05.008",

language = "English",

volume = "108",

pages = "519--529",

journal = "ARCH CARDIOVASC DIS",

issn = "1875-2136",

publisher = "Elsevier Masson",

number = "10",

}

RIS

TY - JOUR

T1 - Advancing knowledge of right ventricular pathophysiology in chronic pressure overload: Insights from experimental studies

AU - Guihaire, Julien

AU - Noly, Pierre Emmanuel

AU - Schrepfer, Sonja

AU - Mercier, Olaf

PY - 2015/10

Y1 - 2015/10

N2 - The right ventricle (RV) has to face major changes in loading conditions due to cardiovascular diseases and pulmonary vascular disorders. Clinical experience supports evidence that the RV better compensates for volume than for pressure overload, and for chronic than for acute changes. For a long time, right ventricular (RV) pathophysiology has been restricted to patterns extrapolated from left heart studies. However, the two ventricles are anatomically, haemodynamically and functionally distinct. RV metabolic properties may also result in a different behaviour in response to pathological conditions compared with the left ventricle. In this review, current knowledge of RV pathophysiology is reported in the setting of chronic pressure overload, including recent experimental findings and emerging concepts. After a time-varying compensated period with preserved cardiac output despite overload conditions, RV failure finally occurs, leading to death. The underlying mechanisms involved in the transition from compensatory hypertrophy to maladaptive remodelling are not completely understood.

AB - The right ventricle (RV) has to face major changes in loading conditions due to cardiovascular diseases and pulmonary vascular disorders. Clinical experience supports evidence that the RV better compensates for volume than for pressure overload, and for chronic than for acute changes. For a long time, right ventricular (RV) pathophysiology has been restricted to patterns extrapolated from left heart studies. However, the two ventricles are anatomically, haemodynamically and functionally distinct. RV metabolic properties may also result in a different behaviour in response to pathological conditions compared with the left ventricle. In this review, current knowledge of RV pathophysiology is reported in the setting of chronic pressure overload, including recent experimental findings and emerging concepts. After a time-varying compensated period with preserved cardiac output despite overload conditions, RV failure finally occurs, leading to death. The underlying mechanisms involved in the transition from compensatory hypertrophy to maladaptive remodelling are not completely understood.

KW - Animals

KW - Blood Pressure

KW - Cardiac Output

KW - Chronic Disease

KW - Humans

KW - Hypertension/complications

KW - Hypertrophy, Right Ventricular/etiology

KW - Pulmonary Circulation

KW - Risk Factors

KW - Treatment Outcome

KW - Ventricular Dysfunction, Right/diagnosis

KW - Ventricular Function, Right

KW - Ventricular Remodeling

U2 - 10.1016/j.acvd.2015.05.008

DO - 10.1016/j.acvd.2015.05.008

M3 - SCORING: Review article

C2 - 26184869

VL - 108

SP - 519

EP - 529

JO - ARCH CARDIOVASC DIS

JF - ARCH CARDIOVASC DIS

SN - 1875-2136

IS - 10

ER -