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Adult generation of glutamatergic olfactory bulb interneurons.

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Adult generation of glutamatergic olfactory bulb interneurons. / Brill, Monika S; Ninkovic, Jovica; Winpenny, Eleanor; Hodge, Rebecca D; Ozen, Ilknur; Yang, Roderick; Lepier, Alexandra; Gascón, Sergio; Erdelyi, Ferenc; Szabo, Gabor; Parras, Carlos; Guillemot, Francois; Frotscher, Michael; Berninger, Benedikt; Hevner, Robert F; Raineteau, Olivier; Götz, Magdalena.

in: NAT NEUROSCI, Jahrgang 12, Nr. 12, 12, 2009, S. 1524-1533.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Brill, MS, Ninkovic, J, Winpenny, E, Hodge, RD, Ozen, I, Yang, R, Lepier, A, Gascón, S, Erdelyi, F, Szabo, G, Parras, C, Guillemot, F, Frotscher, M, Berninger, B, Hevner, RF, Raineteau, O & Götz, M 2009, 'Adult generation of glutamatergic olfactory bulb interneurons.', NAT NEUROSCI, Jg. 12, Nr. 12, 12, S. 1524-1533. <http://www.ncbi.nlm.nih.gov/pubmed/19881504?dopt=Citation>

APA

Brill, M. S., Ninkovic, J., Winpenny, E., Hodge, R. D., Ozen, I., Yang, R., Lepier, A., Gascón, S., Erdelyi, F., Szabo, G., Parras, C., Guillemot, F., Frotscher, M., Berninger, B., Hevner, R. F., Raineteau, O., & Götz, M. (2009). Adult generation of glutamatergic olfactory bulb interneurons. NAT NEUROSCI, 12(12), 1524-1533. [12]. http://www.ncbi.nlm.nih.gov/pubmed/19881504?dopt=Citation

Vancouver

Brill MS, Ninkovic J, Winpenny E, Hodge RD, Ozen I, Yang R et al. Adult generation of glutamatergic olfactory bulb interneurons. NAT NEUROSCI. 2009;12(12):1524-1533. 12.

Bibtex

@article{408644ed27f24142a3cf0969a87e3e34,
title = "Adult generation of glutamatergic olfactory bulb interneurons.",
abstract = "The adult mouse subependymal zone (SEZ) harbors neural stem cells that are thought to exclusively generate GABAergic interneurons of the olfactory bulb. We examined the adult generation of glutamatergic juxtaglomerular neurons, which had dendritic arborizations that projected into adjacent glomeruli, identifying them as short-axon cells. Fate mapping revealed that these originate from Neurog2- and Tbr2-expressing progenitors located in the dorsal region of the SEZ. Examination of the progenitors of these glutamatergic interneurons allowed us to determine the sequential expression of transcription factors in these cells that are thought to be hallmarks of glutamatergic neurogenesis in the developing cerebral cortex and adult hippocampus. Indeed, the molecular specification of these SEZ progenitors allowed for their recruitment into the cerebral cortex after a lesion was induced. Taken together, our data indicate that SEZ progenitors not only produce a population of adult-born glutamatergic juxtaglomerular neurons, but may also provide a previously unknown source of progenitors for endogenous repair.",
keywords = "Animals, Age Factors, Mice, Biological Markers metabolism, Green Fluorescent Proteins genetics, Adult Stem Cells cytology, Axons physiology, Basic Helix-Loop-Helix Transcription Factors metabolism, Brain Diseases pathology, Cell Lineage physiology, Cerebral Cortex cytology, Dendrites physiology, Ependyma cytology, Glutamic Acid physiology, Hippocampus cytology, Interneurons cytology, Mice, Transgenic, Nerve Tissue Proteins metabolism, Olfactory Bulb cytology, T-Box Domain Proteins metabolism, gamma-Aminobutyric Acid physiology, Animals, Age Factors, Mice, Biological Markers metabolism, Green Fluorescent Proteins genetics, Adult Stem Cells cytology, Axons physiology, Basic Helix-Loop-Helix Transcription Factors metabolism, Brain Diseases pathology, Cell Lineage physiology, Cerebral Cortex cytology, Dendrites physiology, Ependyma cytology, Glutamic Acid physiology, Hippocampus cytology, Interneurons cytology, Mice, Transgenic, Nerve Tissue Proteins metabolism, Olfactory Bulb cytology, T-Box Domain Proteins metabolism, gamma-Aminobutyric Acid physiology",
author = "Brill, {Monika S} and Jovica Ninkovic and Eleanor Winpenny and Hodge, {Rebecca D} and Ilknur Ozen and Roderick Yang and Alexandra Lepier and Sergio Gasc{\'o}n and Ferenc Erdelyi and Gabor Szabo and Carlos Parras and Francois Guillemot and Michael Frotscher and Benedikt Berninger and Hevner, {Robert F} and Olivier Raineteau and Magdalena G{\"o}tz",
year = "2009",
language = "Deutsch",
volume = "12",
pages = "1524--1533",
journal = "NAT NEUROSCI",
issn = "1097-6256",
publisher = "NATURE PUBLISHING GROUP",
number = "12",

}

RIS

TY - JOUR

T1 - Adult generation of glutamatergic olfactory bulb interneurons.

AU - Brill, Monika S

AU - Ninkovic, Jovica

AU - Winpenny, Eleanor

AU - Hodge, Rebecca D

AU - Ozen, Ilknur

AU - Yang, Roderick

AU - Lepier, Alexandra

AU - Gascón, Sergio

AU - Erdelyi, Ferenc

AU - Szabo, Gabor

AU - Parras, Carlos

AU - Guillemot, Francois

AU - Frotscher, Michael

AU - Berninger, Benedikt

AU - Hevner, Robert F

AU - Raineteau, Olivier

AU - Götz, Magdalena

PY - 2009

Y1 - 2009

N2 - The adult mouse subependymal zone (SEZ) harbors neural stem cells that are thought to exclusively generate GABAergic interneurons of the olfactory bulb. We examined the adult generation of glutamatergic juxtaglomerular neurons, which had dendritic arborizations that projected into adjacent glomeruli, identifying them as short-axon cells. Fate mapping revealed that these originate from Neurog2- and Tbr2-expressing progenitors located in the dorsal region of the SEZ. Examination of the progenitors of these glutamatergic interneurons allowed us to determine the sequential expression of transcription factors in these cells that are thought to be hallmarks of glutamatergic neurogenesis in the developing cerebral cortex and adult hippocampus. Indeed, the molecular specification of these SEZ progenitors allowed for their recruitment into the cerebral cortex after a lesion was induced. Taken together, our data indicate that SEZ progenitors not only produce a population of adult-born glutamatergic juxtaglomerular neurons, but may also provide a previously unknown source of progenitors for endogenous repair.

AB - The adult mouse subependymal zone (SEZ) harbors neural stem cells that are thought to exclusively generate GABAergic interneurons of the olfactory bulb. We examined the adult generation of glutamatergic juxtaglomerular neurons, which had dendritic arborizations that projected into adjacent glomeruli, identifying them as short-axon cells. Fate mapping revealed that these originate from Neurog2- and Tbr2-expressing progenitors located in the dorsal region of the SEZ. Examination of the progenitors of these glutamatergic interneurons allowed us to determine the sequential expression of transcription factors in these cells that are thought to be hallmarks of glutamatergic neurogenesis in the developing cerebral cortex and adult hippocampus. Indeed, the molecular specification of these SEZ progenitors allowed for their recruitment into the cerebral cortex after a lesion was induced. Taken together, our data indicate that SEZ progenitors not only produce a population of adult-born glutamatergic juxtaglomerular neurons, but may also provide a previously unknown source of progenitors for endogenous repair.

KW - Animals

KW - Age Factors

KW - Mice

KW - Biological Markers metabolism

KW - Green Fluorescent Proteins genetics

KW - Adult Stem Cells cytology

KW - Axons physiology

KW - Basic Helix-Loop-Helix Transcription Factors metabolism

KW - Brain Diseases pathology

KW - Cell Lineage physiology

KW - Cerebral Cortex cytology

KW - Dendrites physiology

KW - Ependyma cytology

KW - Glutamic Acid physiology

KW - Hippocampus cytology

KW - Interneurons cytology

KW - Mice, Transgenic

KW - Nerve Tissue Proteins metabolism

KW - Olfactory Bulb cytology

KW - T-Box Domain Proteins metabolism

KW - gamma-Aminobutyric Acid physiology

KW - Animals

KW - Age Factors

KW - Mice

KW - Biological Markers metabolism

KW - Green Fluorescent Proteins genetics

KW - Adult Stem Cells cytology

KW - Axons physiology

KW - Basic Helix-Loop-Helix Transcription Factors metabolism

KW - Brain Diseases pathology

KW - Cell Lineage physiology

KW - Cerebral Cortex cytology

KW - Dendrites physiology

KW - Ependyma cytology

KW - Glutamic Acid physiology

KW - Hippocampus cytology

KW - Interneurons cytology

KW - Mice, Transgenic

KW - Nerve Tissue Proteins metabolism

KW - Olfactory Bulb cytology

KW - T-Box Domain Proteins metabolism

KW - gamma-Aminobutyric Acid physiology

M3 - SCORING: Zeitschriftenaufsatz

VL - 12

SP - 1524

EP - 1533

JO - NAT NEUROSCI

JF - NAT NEUROSCI

SN - 1097-6256

IS - 12

M1 - 12

ER -