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Adoptive transfer of HBV immunity by kidney transplantation and the effect of postoperative vaccination

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Adoptive transfer of HBV immunity by kidney transplantation and the effect of postoperative vaccination. / Dahmen, Uta; Gu, YanLi; Dirsch, Olaf; Li, Jun; Polywka, Susanne; Doebel, Lothar; Shen, Kai; Broelsch, Christoph Erich.

in: ANTIVIR RES, Jahrgang 56, Nr. 1, 10.2002, S. 29-37.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dahmen, U, Gu, Y, Dirsch, O, Li, J, Polywka, S, Doebel, L, Shen, K & Broelsch, CE 2002, 'Adoptive transfer of HBV immunity by kidney transplantation and the effect of postoperative vaccination', ANTIVIR RES, Jg. 56, Nr. 1, S. 29-37.

APA

Dahmen, U., Gu, Y., Dirsch, O., Li, J., Polywka, S., Doebel, L., Shen, K., & Broelsch, C. E. (2002). Adoptive transfer of HBV immunity by kidney transplantation and the effect of postoperative vaccination. ANTIVIR RES, 56(1), 29-37.

Vancouver

Dahmen U, Gu Y, Dirsch O, Li J, Polywka S, Doebel L et al. Adoptive transfer of HBV immunity by kidney transplantation and the effect of postoperative vaccination. ANTIVIR RES. 2002 Okt;56(1):29-37.

Bibtex

@article{0e782455a3fe4f70a0ffd81732583501,
title = "Adoptive transfer of HBV immunity by kidney transplantation and the effect of postoperative vaccination",
abstract = "Transfer of hepatitis B immunity occurs upon the transfer of immunologically active cells from the donor to the recipient by means of an organ graft. This has been repeatedly demonstrated for bone marrow and liver transplantations. Evidence is now presented for the transfer of anti-hepatitis B surface antibodies (anti-HBs) after kidney transplantation in rats. Kidney donors from one syngeneic and two allogeneic rat strains were immunized twice with 4 microg of recombinant hepatitis B vaccine. In week 6 after the first vaccination, kidney grafts were transplanted into Lewis (LEW) rats. Half of the recipients underwent daily immunosuppressive treatment with cyclosporin A (CsA). All recipients were vaccinated either after 10 weeks or 1 week postoperatively. Anti-HBs titer was measured weekly. Effective anti-HBs titers (10-227 mIU/ml, lasting for 1-7 weeks) were detected in 86% (25/29) of recipient rats, whose corresponding donors all had a titer above 15,000 mIU/ml. Immunosuppression enhanced the donor-derived immunity in terms of recipient-to-donor titer ratio, maximal titer and titer persistence.",
keywords = "Adoptive Transfer, Animals, Cyclosporine, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Vaccines, Hepatitis B virus, Immunosuppression, Immunosuppressive Agents, Kidney Transplantation, Rats, Rats, Inbred Lew, Vaccination, Vaccines, Synthetic, Journal Article, Research Support, Non-U.S. Gov't",
author = "Uta Dahmen and YanLi Gu and Olaf Dirsch and Jun Li and Susanne Polywka and Lothar Doebel and Kai Shen and Broelsch, {Christoph Erich}",
year = "2002",
month = oct,
language = "English",
volume = "56",
pages = "29--37",
number = "1",

}

RIS

TY - JOUR

T1 - Adoptive transfer of HBV immunity by kidney transplantation and the effect of postoperative vaccination

AU - Dahmen, Uta

AU - Gu, YanLi

AU - Dirsch, Olaf

AU - Li, Jun

AU - Polywka, Susanne

AU - Doebel, Lothar

AU - Shen, Kai

AU - Broelsch, Christoph Erich

PY - 2002/10

Y1 - 2002/10

N2 - Transfer of hepatitis B immunity occurs upon the transfer of immunologically active cells from the donor to the recipient by means of an organ graft. This has been repeatedly demonstrated for bone marrow and liver transplantations. Evidence is now presented for the transfer of anti-hepatitis B surface antibodies (anti-HBs) after kidney transplantation in rats. Kidney donors from one syngeneic and two allogeneic rat strains were immunized twice with 4 microg of recombinant hepatitis B vaccine. In week 6 after the first vaccination, kidney grafts were transplanted into Lewis (LEW) rats. Half of the recipients underwent daily immunosuppressive treatment with cyclosporin A (CsA). All recipients were vaccinated either after 10 weeks or 1 week postoperatively. Anti-HBs titer was measured weekly. Effective anti-HBs titers (10-227 mIU/ml, lasting for 1-7 weeks) were detected in 86% (25/29) of recipient rats, whose corresponding donors all had a titer above 15,000 mIU/ml. Immunosuppression enhanced the donor-derived immunity in terms of recipient-to-donor titer ratio, maximal titer and titer persistence.

AB - Transfer of hepatitis B immunity occurs upon the transfer of immunologically active cells from the donor to the recipient by means of an organ graft. This has been repeatedly demonstrated for bone marrow and liver transplantations. Evidence is now presented for the transfer of anti-hepatitis B surface antibodies (anti-HBs) after kidney transplantation in rats. Kidney donors from one syngeneic and two allogeneic rat strains were immunized twice with 4 microg of recombinant hepatitis B vaccine. In week 6 after the first vaccination, kidney grafts were transplanted into Lewis (LEW) rats. Half of the recipients underwent daily immunosuppressive treatment with cyclosporin A (CsA). All recipients were vaccinated either after 10 weeks or 1 week postoperatively. Anti-HBs titer was measured weekly. Effective anti-HBs titers (10-227 mIU/ml, lasting for 1-7 weeks) were detected in 86% (25/29) of recipient rats, whose corresponding donors all had a titer above 15,000 mIU/ml. Immunosuppression enhanced the donor-derived immunity in terms of recipient-to-donor titer ratio, maximal titer and titer persistence.

KW - Adoptive Transfer

KW - Animals

KW - Cyclosporine

KW - Hepatitis B

KW - Hepatitis B Antibodies

KW - Hepatitis B Vaccines

KW - Hepatitis B virus

KW - Immunosuppression

KW - Immunosuppressive Agents

KW - Kidney Transplantation

KW - Rats

KW - Rats, Inbred Lew

KW - Vaccination

KW - Vaccines, Synthetic

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - SCORING: Journal article

C2 - 12323397

VL - 56

SP - 29

EP - 37

IS - 1

ER -