Adoptive Transfer of CD8+ T Cell Clones Derived from Central Memory Cells.
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Adoptive Transfer of CD8+ T Cell Clones Derived from Central Memory Cells. / Riddell, Stanley R; Berger, Susanna Carolina; Jensen, Michael C.
Patent Nr.: US10,400,215B2.Publikationen: Patent › Patentschriften und andere Schutzrechte
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RIS
TY - PAT
T1 - Adoptive Transfer of CD8+ T Cell Clones Derived from Central Memory Cells.
AU - Riddell, Stanley R
AU - Berger, Susanna Carolina
AU - Jensen, Michael C
PY - 2014
Y1 - 2014
N2 - The present invention provides a method of carrying out adoptive immunotherapy in a primate subject in need thereof by administering the subject a cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount. The method comprises administering as the CTL preparation a preparation consisting essentially of an in vitro expanded primate CTL population, the CTL population enriched prior to expansion for central memory T lymphocytes, and depleted prior to expansion of effector memory T lymphocytes. In some embodiments, the method may further comprise concurrently administering Interleukin-15 to the subject in an amount effective to increase the proliferation of the central memory T cells in the subject. Pharmaceutical formulations produced by the method, and methods of using the same, are also described.
AB - The present invention provides a method of carrying out adoptive immunotherapy in a primate subject in need thereof by administering the subject a cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount. The method comprises administering as the CTL preparation a preparation consisting essentially of an in vitro expanded primate CTL population, the CTL population enriched prior to expansion for central memory T lymphocytes, and depleted prior to expansion of effector memory T lymphocytes. In some embodiments, the method may further comprise concurrently administering Interleukin-15 to the subject in an amount effective to increase the proliferation of the central memory T cells in the subject. Pharmaceutical formulations produced by the method, and methods of using the same, are also described.
M3 - Patent
M1 - US10,400,215B2
Y2 - 2014/06/12
ER -