Adoptive transfer of allogeneic antigen-specific T cells
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Adoptive transfer of allogeneic antigen-specific T cells. / Riddell, Stanley R; Bleakley, Marie; Nishida, Tetsuya; Berger, Carolina; Warren, Edus H.
in: BIOL BLOOD MARROW TR, Jahrgang 12, Nr. 1 Suppl 1, 01.2006, S. 9-12.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Adoptive transfer of allogeneic antigen-specific T cells
AU - Riddell, Stanley R
AU - Bleakley, Marie
AU - Nishida, Tetsuya
AU - Berger, Carolina
AU - Warren, Edus H
PY - 2006/1
Y1 - 2006/1
N2 - Animal models and human studies of allogeneic hematopoietic cell transplantation (HCT) demonstrate that immunologic nonidentity between donor and recipient is responsible for a graft versus leukemia (GVL) effect that contributes to complete tumor eradication. A variety of immune cells have been implicated in the GVL effect including NK cells, B cells, and CD4(+) and CD8(+) T cells that recognize minor histocompatibility (H) or leukemia-associated antigens. Here we discuss strategies for employing T cells specific for minor H antigens to augment the GVL effect.
AB - Animal models and human studies of allogeneic hematopoietic cell transplantation (HCT) demonstrate that immunologic nonidentity between donor and recipient is responsible for a graft versus leukemia (GVL) effect that contributes to complete tumor eradication. A variety of immune cells have been implicated in the GVL effect including NK cells, B cells, and CD4(+) and CD8(+) T cells that recognize minor histocompatibility (H) or leukemia-associated antigens. Here we discuss strategies for employing T cells specific for minor H antigens to augment the GVL effect.
KW - Adoptive Transfer
KW - Animals
KW - B-Lymphocytes/immunology
KW - CD4-Positive T-Lymphocytes/immunology
KW - CD8-Positive T-Lymphocytes/immunology
KW - Graft vs Leukemia Effect/immunology
KW - Hematopoietic Stem Cell Transplantation
KW - Humans
KW - Isoantigens/immunology
KW - Killer Cells, Natural/immunology
KW - Minor Histocompatibility Antigens/immunology
U2 - 10.1016/j.bbmt.2005.10.025
DO - 10.1016/j.bbmt.2005.10.025
M3 - SCORING: Review article
C2 - 16399578
VL - 12
SP - 9
EP - 12
JO - BIOL BLOOD MARROW TR
JF - BIOL BLOOD MARROW TR
SN - 1083-8791
IS - 1 Suppl 1
ER -