Adjuvant therapy in node-positive vulvar cancer
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Adjuvant therapy in node-positive vulvar cancer. / Mahner, Sven; Trillsch, Fabian; Kock, Lilli; Rohsbach, Donata; Petersen, Cordula; Krüll, Andreas; Harter, Philipp; Jänicke, Fritz; Woelber, Linn.
in: EXPERT REV ANTICANC, Jahrgang 13, Nr. 7, 01.07.2013, S. 839-44.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Adjuvant therapy in node-positive vulvar cancer
AU - Mahner, Sven
AU - Trillsch, Fabian
AU - Kock, Lilli
AU - Rohsbach, Donata
AU - Petersen, Cordula
AU - Krüll, Andreas
AU - Harter, Philipp
AU - Jänicke, Fritz
AU - Woelber, Linn
PY - 2013/7/1
Y1 - 2013/7/1
N2 - Due to an increasing incidence with concurrently decreasing age at onset, vulvar cancer represents a current challenge for gynecologic oncologists. Positive lymph nodes of the groins have been proven to be the most important prognostic factor for affected patients, significantly impairing overall survival. Distinct criteria for indication of adjuvant therapy following primary tumor resection and groin surgery are still under debate. At present, only patients with two or more positive lymph nodes are treated with adjuvant radiotherapy despite growing evidence that patients with only one nodal macrometastasis already have a significantly worse outcome and might benefit from adjuvant treatment. This review discusses existing evidence focusing on different therapeutic approaches and their potential indication in vulvar cancer. Based on the available data the need for future trials is being elaborated.
AB - Due to an increasing incidence with concurrently decreasing age at onset, vulvar cancer represents a current challenge for gynecologic oncologists. Positive lymph nodes of the groins have been proven to be the most important prognostic factor for affected patients, significantly impairing overall survival. Distinct criteria for indication of adjuvant therapy following primary tumor resection and groin surgery are still under debate. At present, only patients with two or more positive lymph nodes are treated with adjuvant radiotherapy despite growing evidence that patients with only one nodal macrometastasis already have a significantly worse outcome and might benefit from adjuvant treatment. This review discusses existing evidence focusing on different therapeutic approaches and their potential indication in vulvar cancer. Based on the available data the need for future trials is being elaborated.
KW - Age of Onset
KW - Chemoradiotherapy, Adjuvant
KW - Chemotherapy, Adjuvant
KW - Female
KW - Humans
KW - Lymph Nodes
KW - Lymphatic Metastasis
KW - Prognosis
KW - Radiotherapy, Adjuvant
KW - Survival Rate
KW - Vulvar Neoplasms
U2 - 10.1586/14737140.2013.811063
DO - 10.1586/14737140.2013.811063
M3 - SCORING: Journal article
C2 - 23875662
VL - 13
SP - 839
EP - 844
JO - EXPERT REV ANTICANC
JF - EXPERT REV ANTICANC
SN - 1473-7140
IS - 7
ER -