Adenosine(5') oligophospho-(5') guanosines and guanosine(5') oligophospho-(5') guanosines in human platelets
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Adenosine(5') oligophospho-(5') guanosines and guanosine(5') oligophospho-(5') guanosines in human platelets. / Schlüter, H; Grobeta, I; Bachmann, J; Kaufmann, R; van der Giet, M; Tepel, M; Nofer, J R; Assmann, G; Karas, M; Jankowski, J; Zidek, W.
in: J CLIN INVEST, Jahrgang 101, Nr. 3, 01.02.1998, S. 682-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Adenosine(5') oligophospho-(5') guanosines and guanosine(5') oligophospho-(5') guanosines in human platelets
AU - Schlüter, H
AU - Grobeta, I
AU - Bachmann, J
AU - Kaufmann, R
AU - van der Giet, M
AU - Tepel, M
AU - Nofer, J R
AU - Assmann, G
AU - Karas, M
AU - Jankowski, J
AU - Zidek, W
PY - 1998/2/1
Y1 - 1998/2/1
N2 - We isolated and identified nucleoside(5') oligophospho-(5') nucleosides containing adenosine and guanosine (ApnG; n = 3-6) as well as diguanosine polyphosphates (GpnG; n = 3-6) in human platelets. For identification, UV spectrometry, matrix-assisted laser desorption/ionization, postsource decay matrix-assisted laser desorption/ionization mass spectrometry, and enzymatic cleavage experiments were used. The adenosine(5') oligophospho-(5') guanosines act as vasoconstrictors and growth factors. The diguanosine polyphosphates are potent modulators of growth in vascular smooth muscle cells, but do not affect vascular tone.
AB - We isolated and identified nucleoside(5') oligophospho-(5') nucleosides containing adenosine and guanosine (ApnG; n = 3-6) as well as diguanosine polyphosphates (GpnG; n = 3-6) in human platelets. For identification, UV spectrometry, matrix-assisted laser desorption/ionization, postsource decay matrix-assisted laser desorption/ionization mass spectrometry, and enzymatic cleavage experiments were used. The adenosine(5') oligophospho-(5') guanosines act as vasoconstrictors and growth factors. The diguanosine polyphosphates are potent modulators of growth in vascular smooth muscle cells, but do not affect vascular tone.
KW - Adenosine
KW - Blood Platelets
KW - Dinucleoside Phosphates
KW - Extracellular Space
KW - Guanosine
KW - Humans
KW - Kidney
KW - Muscle, Smooth, Vascular
KW - Nucleotidases
KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
KW - Vasoconstrictor Agents
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1172/JCI119882
DO - 10.1172/JCI119882
M3 - SCORING: Journal article
C2 - 9449703
VL - 101
SP - 682
EP - 688
JO - J CLIN INVEST
JF - J CLIN INVEST
SN - 0021-9738
IS - 3
ER -