PortalPublikationenAdaptive circuit dynamics across human cortex during evidenc...

Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments

Standard

Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments. / Murphy, Peter R; Wilming, Niklas; Hernandez-Bocanegra, Diana C; Prat-Ortega, Genis; Donner, Tobias H.

in: NAT NEUROSCI, Jahrgang 24, Nr. 7, 07.2021, S. 987-997.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Murphy, PR, Wilming, N, Hernandez-Bocanegra, DC, Prat-Ortega, G & Donner, TH 2021, 'Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments', NAT NEUROSCI, Jg. 24, Nr. 7, S. 987-997. https://doi.org/10.1038/s41593-021-00839-z

APA

Murphy, P. R., Wilming, N., Hernandez-Bocanegra, D. C., Prat-Ortega, G., & Donner, T. H. (2021). Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments. NAT NEUROSCI, 24(7), 987-997. https://doi.org/10.1038/s41593-021-00839-z

Vancouver

Murphy PR, Wilming N, Hernandez-Bocanegra DC, Prat-Ortega G, Donner TH. Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments. NAT NEUROSCI. 2021 Jul;24(7):987-997. https://doi.org/10.1038/s41593-021-00839-z

Bibtex

@article{5568663f138a4079bfb7b6abe054d611,
title = "Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments",
abstract = "Many decisions under uncertainty entail the temporal accumulation of evidence that informs about the state of the environment. When environments are subject to hidden changes in their state, maximizing accuracy and reward requires non-linear accumulation of evidence. How this adaptive, non-linear computation is realized in the brain is unknown. We analyzed human behavior and cortical population activity (measured with magnetoencephalography) recorded during visual evidence accumulation in a changing environment. Behavior and decision-related activity in cortical regions involved in action planning exhibited hallmarks of adaptive evidence accumulation, which could also be implemented by a recurrent cortical microcircuit. Decision dynamics in action-encoding parietal and frontal regions were mirrored in a frequency-specific modulation of the state of the visual cortex that depended on pupil-linked arousal and the expected probability of change. These findings link normative decision computations to recurrent cortical circuit dynamics and highlight the adaptive nature of decision-related feedback to the sensory cortex.",
keywords = "Adult, Cerebral Cortex/physiology, Decision Making/physiology, Female, Humans, Magnetoencephalography, Male, Models, Neurological",
author = "Murphy, {Peter R} and Niklas Wilming and Hernandez-Bocanegra, {Diana C} and Genis Prat-Ortega and Donner, {Tobias H}",
year = "2021",
month = jul,
doi = "10.1038/s41593-021-00839-z",
language = "English",
volume = "24",
pages = "987--997",
journal = "NAT NEUROSCI",
issn = "1097-6256",
publisher = "NATURE PUBLISHING GROUP",
number = "7",

}

RIS

TY - JOUR

T1 - Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments

AU - Murphy, Peter R

AU - Wilming, Niklas

AU - Hernandez-Bocanegra, Diana C

AU - Prat-Ortega, Genis

AU - Donner, Tobias H

PY - 2021/7

Y1 - 2021/7

N2 - Many decisions under uncertainty entail the temporal accumulation of evidence that informs about the state of the environment. When environments are subject to hidden changes in their state, maximizing accuracy and reward requires non-linear accumulation of evidence. How this adaptive, non-linear computation is realized in the brain is unknown. We analyzed human behavior and cortical population activity (measured with magnetoencephalography) recorded during visual evidence accumulation in a changing environment. Behavior and decision-related activity in cortical regions involved in action planning exhibited hallmarks of adaptive evidence accumulation, which could also be implemented by a recurrent cortical microcircuit. Decision dynamics in action-encoding parietal and frontal regions were mirrored in a frequency-specific modulation of the state of the visual cortex that depended on pupil-linked arousal and the expected probability of change. These findings link normative decision computations to recurrent cortical circuit dynamics and highlight the adaptive nature of decision-related feedback to the sensory cortex.

AB - Many decisions under uncertainty entail the temporal accumulation of evidence that informs about the state of the environment. When environments are subject to hidden changes in their state, maximizing accuracy and reward requires non-linear accumulation of evidence. How this adaptive, non-linear computation is realized in the brain is unknown. We analyzed human behavior and cortical population activity (measured with magnetoencephalography) recorded during visual evidence accumulation in a changing environment. Behavior and decision-related activity in cortical regions involved in action planning exhibited hallmarks of adaptive evidence accumulation, which could also be implemented by a recurrent cortical microcircuit. Decision dynamics in action-encoding parietal and frontal regions were mirrored in a frequency-specific modulation of the state of the visual cortex that depended on pupil-linked arousal and the expected probability of change. These findings link normative decision computations to recurrent cortical circuit dynamics and highlight the adaptive nature of decision-related feedback to the sensory cortex.

KW - Adult

KW - Cerebral Cortex/physiology

KW - Decision Making/physiology

KW - Female

KW - Humans

KW - Magnetoencephalography

KW - Male

KW - Models, Neurological

U2 - 10.1038/s41593-021-00839-z

DO - 10.1038/s41593-021-00839-z

M3 - SCORING: Journal article

C2 - 33903770

VL - 24

SP - 987

EP - 997

JO - NAT NEUROSCI

JF - NAT NEUROSCI

SN - 1097-6256

IS - 7

ER -