Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction
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Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. / El-Ahmadi, Abdellatif; Abassi, Mujahed Sebastian; Andersson, Hedvig Bille; Engstrøm, Thomas; Clemmensen, Peter; Helqvist, Steffen; Jørgensen, Erik; Kelbæk, Henning; Pedersen, Frants; Saunamäki, Kari; Lønborg, Jacob; Holmvang, Lene.
in: PLOS ONE, Jahrgang 14, Nr. 12, e0226625, 2019.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction
AU - El-Ahmadi, Abdellatif
AU - Abassi, Mujahed Sebastian
AU - Andersson, Hedvig Bille
AU - Engstrøm, Thomas
AU - Clemmensen, Peter
AU - Helqvist, Steffen
AU - Jørgensen, Erik
AU - Kelbæk, Henning
AU - Pedersen, Frants
AU - Saunamäki, Kari
AU - Lønborg, Jacob
AU - Holmvang, Lene
PY - 2019
Y1 - 2019
N2 - OBJECTIVES: The aim of the study was to investigate the incidence, risk factors and long-term prognosis of acute kidney injury (AKI) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (primary PCI).METHOD: A large-scale, retrospective cohort study based on procedure-related variables, biochemical and mortality data collected between 2009 and 2014 at Rigshospitalet, Copenhagen, Denmark. AKI was defined as an increase in serum creatinine of 25% during the first 72 hours after the index procedure.RESULTS: A total of 4239 patients were treated with primary PCI of whom 4002 had available creatinine measurements allowing for assessment of AKI and inclusion in this study. The mean creatinine value upon presentation for all patients was 84 μmol/l (standard deviation (SD) ±40) and 97 μmol/l (SD ±53) at peak. AKI occurred in a total of 765 (19.1%) patients. Independent risk factors for the occurrence of AKI were age, time from symptom onset to procedure, peak value of troponin-T, female sex and the contrast volume to eGFR ratio. In a multivariable adjusted analysis AKI was independently associated with a higher mortality rate at 5 years follow-up (hazard ratio 1.39 [95%-confidence interval 1.03-1.88]).CONCLUSION: In STEMI patients treated with primary PCI one in five experiences acute kidney injury, which was associated with a substantial increase in both short- and long-term mortality.
AB - OBJECTIVES: The aim of the study was to investigate the incidence, risk factors and long-term prognosis of acute kidney injury (AKI) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (primary PCI).METHOD: A large-scale, retrospective cohort study based on procedure-related variables, biochemical and mortality data collected between 2009 and 2014 at Rigshospitalet, Copenhagen, Denmark. AKI was defined as an increase in serum creatinine of 25% during the first 72 hours after the index procedure.RESULTS: A total of 4239 patients were treated with primary PCI of whom 4002 had available creatinine measurements allowing for assessment of AKI and inclusion in this study. The mean creatinine value upon presentation for all patients was 84 μmol/l (standard deviation (SD) ±40) and 97 μmol/l (SD ±53) at peak. AKI occurred in a total of 765 (19.1%) patients. Independent risk factors for the occurrence of AKI were age, time from symptom onset to procedure, peak value of troponin-T, female sex and the contrast volume to eGFR ratio. In a multivariable adjusted analysis AKI was independently associated with a higher mortality rate at 5 years follow-up (hazard ratio 1.39 [95%-confidence interval 1.03-1.88]).CONCLUSION: In STEMI patients treated with primary PCI one in five experiences acute kidney injury, which was associated with a substantial increase in both short- and long-term mortality.
KW - Acute Kidney Injury/epidemiology
KW - Age Factors
KW - Aged
KW - Contrast Media/adverse effects
KW - Creatinine/blood
KW - Denmark/epidemiology
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Percutaneous Coronary Intervention/adverse effects
KW - Prognosis
KW - Retrospective Studies
KW - Risk Factors
KW - ST Elevation Myocardial Infarction/surgery
KW - Sex Factors
KW - Troponin T/blood
U2 - 10.1371/journal.pone.0226625
DO - 10.1371/journal.pone.0226625
M3 - SCORING: Journal article
C2 - 31860670
VL - 14
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 12
M1 - e0226625
ER -
