Acute intoxication with aniline: detection of acetaminophen as aniline metabolite.
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Acute intoxication with aniline: detection of acetaminophen as aniline metabolite. / Iwersen-Bergmann, Stefanie; Schmoldt, A.
in: INT J LEGAL MED, Jahrgang 113, Nr. 3, 3, 2000, S. 171-174.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Acute intoxication with aniline: detection of acetaminophen as aniline metabolite.
AU - Iwersen-Bergmann, Stefanie
AU - Schmoldt, A
PY - 2000
Y1 - 2000
N2 - A 47-year-old woman unwittingly ingested an unknown substance together with her breakfast coffee. She suffered effects such as strong headache, generalized cyanosis, and a burning sensation of the lips and collapsed some minutes later. After admission into hospital a methemoglobin level of 35% was determined in the blood. Treatment by administration of tolonium chloride (toluidine blue) resulted in complete recovery of the patient. The toxic agent was identified as aniline by GC with mass selective detection after organic solvent extraction and 11 h after ingestion the plasma aniline level was 0.13 mg/l. Acetanilide (0.79 mg/ml) and acetaminophen (2.3 mg/ml) were identified in plasma as metabolites of aniline. It was assumed that a high metabolic capacity for acetylation protected the victim from more severe reactions. Her husband confessed later that he had tried to poison her.
AB - A 47-year-old woman unwittingly ingested an unknown substance together with her breakfast coffee. She suffered effects such as strong headache, generalized cyanosis, and a burning sensation of the lips and collapsed some minutes later. After admission into hospital a methemoglobin level of 35% was determined in the blood. Treatment by administration of tolonium chloride (toluidine blue) resulted in complete recovery of the patient. The toxic agent was identified as aniline by GC with mass selective detection after organic solvent extraction and 11 h after ingestion the plasma aniline level was 0.13 mg/l. Acetanilide (0.79 mg/ml) and acetaminophen (2.3 mg/ml) were identified in plasma as metabolites of aniline. It was assumed that a high metabolic capacity for acetylation protected the victim from more severe reactions. Her husband confessed later that he had tried to poison her.
KW - Humans
KW - Female
KW - Middle Aged
KW - Survival Analysis
KW - Acetylation
KW - Acetaminophen/blood
KW - Acetanilides/blood
KW - Aniline Compounds/metabolism/poisoning
KW - Forensic Medicine/methods
KW - Gas Chromatography-Mass Spectrometry
KW - Homicide
KW - Immunoassay/methods
KW - Poisoning/blood/diagnosis/drug therapy/mortality
KW - Tolonium Chloride/therapeutic use
KW - Humans
KW - Female
KW - Middle Aged
KW - Survival Analysis
KW - Acetylation
KW - Acetaminophen/blood
KW - Acetanilides/blood
KW - Aniline Compounds/metabolism/poisoning
KW - Forensic Medicine/methods
KW - Gas Chromatography-Mass Spectrometry
KW - Homicide
KW - Immunoassay/methods
KW - Poisoning/blood/diagnosis/drug therapy/mortality
KW - Tolonium Chloride/therapeutic use
M3 - SCORING: Journal article
VL - 113
SP - 171
EP - 174
JO - INT J LEGAL MED
JF - INT J LEGAL MED
SN - 0937-9827
IS - 3
M1 - 3
ER -
