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Acute HIV-1 infection is associated with increased plasma levels of heme oxygenase-1 and presence of heme oxygenase-1-specific regulatory T cells

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Acute HIV-1 infection is associated with increased plasma levels of heme oxygenase-1 and presence of heme oxygenase-1-specific regulatory T cells. / Angin, Mathieu; Fathi, Anahita; King, Melanie; Ledoux, Mary B; Piechocka-Trocha, Alicja; Altfeld, Marcus; Addo, Marylyn M.

in: AIDS, Jahrgang 31, Nr. 5, 13.03.2017, S. 635-641.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Angin, M, Fathi, A, King, M, Ledoux, MB, Piechocka-Trocha, A, Altfeld, M & Addo, MM 2017, 'Acute HIV-1 infection is associated with increased plasma levels of heme oxygenase-1 and presence of heme oxygenase-1-specific regulatory T cells', AIDS, Jg. 31, Nr. 5, S. 635-641. https://doi.org/10.1097/QAD.0000000000001390

APA

Angin, M., Fathi, A., King, M., Ledoux, M. B., Piechocka-Trocha, A., Altfeld, M., & Addo, M. M. (2017). Acute HIV-1 infection is associated with increased plasma levels of heme oxygenase-1 and presence of heme oxygenase-1-specific regulatory T cells. AIDS, 31(5), 635-641. https://doi.org/10.1097/QAD.0000000000001390

Vancouver

Angin M, Fathi A, King M, Ledoux MB, Piechocka-Trocha A, Altfeld M et al. Acute HIV-1 infection is associated with increased plasma levels of heme oxygenase-1 and presence of heme oxygenase-1-specific regulatory T cells. AIDS. 2017 Mär 13;31(5):635-641. https://doi.org/10.1097/QAD.0000000000001390

Bibtex

@article{f2a5a5009a424efbb1c8cb6b69647d4e,
title = "Acute HIV-1 infection is associated with increased plasma levels of heme oxygenase-1 and presence of heme oxygenase-1-specific regulatory T cells",
abstract = "OBJECTIVE: Heme oxygenase-1 (HO-1) is an inducible stress response protein with potent anti-inflammatory activity and recent data suggest a potentially beneficial role in HIV pathogenesis. We investigated the impact of HO-1 and a novel subset of HO-1-specific CD8 regulatory T cells on virus-specific T-cell immunity in HIV-1-infected individuals.METHODS: HO-1 protein levels were quantified in plasma from individuals at different stages of HIV-1 disease and longitudinally following primary HIV infection. HO-1-specific CD8 T cells were investigated by flow cytometry using human leukocyte antigen (HLA) class I pentamers. Flow-sorted HO-1-specific CD8 T cells were cultured and tested for suppressive activity on HIV-1-specific cytotoxic T-cell clones clones. HO-1 gene expression was determined in sorted peripheral blood mononuclear cell (PBMC) subsets from individuals with acute HIV-1 infection.RESULTS: HO-1 plasma levels were significantly increased in HIV-1 infection, with the highest levels in individuals with acute HIV-1 infection, and gradually declined over time. The frequency of CD8 T cells specific for HO-1 was elevated in study participants with primary HIV-1 infection and flow-sorted HO-1-specific CD8 T cells were capable of suppressing HIV-1-specific lysis of cytotoxic T-cell clones clones. HO-1 gene expression was upregulated in multiple immune cell subsets during acute HIV-1 infection and HO-1 overexpression modulated anti-HIV immunity in vitro.CONCLUSION: Our data suggest that HO-1 is induced during acute HIV-1 infection, likely mediating anti-inflammatory effects and driving expansion of HO-1-specific CD8 regulatory T cells capable of suppressing HIV-1-specific immune responses in vitro. The investigation of HO-1 and the novel CD8 regulatory cell type described here provide further insight into immune regulation in HIV-1 infection and may hold potential for future immunotherapeutic intervention.",
keywords = "CD8-Positive T-Lymphocytes, Cells, Cultured, Flow Cytometry, HIV Infections, HIV-1, Heme Oxygenase-1, Humans, Immunophenotyping, Longitudinal Studies, Plasma, T-Lymphocytes, Regulatory, Journal Article",
author = "Mathieu Angin and Anahita Fathi and Melanie King and Ledoux, {Mary B} and Alicja Piechocka-Trocha and Marcus Altfeld and Addo, {Marylyn M}",
year = "2017",
month = mar,
day = "13",
doi = "10.1097/QAD.0000000000001390",
language = "English",
volume = "31",
pages = "635--641",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Acute HIV-1 infection is associated with increased plasma levels of heme oxygenase-1 and presence of heme oxygenase-1-specific regulatory T cells

AU - Angin, Mathieu

AU - Fathi, Anahita

AU - King, Melanie

AU - Ledoux, Mary B

AU - Piechocka-Trocha, Alicja

AU - Altfeld, Marcus

AU - Addo, Marylyn M

PY - 2017/3/13

Y1 - 2017/3/13

N2 - OBJECTIVE: Heme oxygenase-1 (HO-1) is an inducible stress response protein with potent anti-inflammatory activity and recent data suggest a potentially beneficial role in HIV pathogenesis. We investigated the impact of HO-1 and a novel subset of HO-1-specific CD8 regulatory T cells on virus-specific T-cell immunity in HIV-1-infected individuals.METHODS: HO-1 protein levels were quantified in plasma from individuals at different stages of HIV-1 disease and longitudinally following primary HIV infection. HO-1-specific CD8 T cells were investigated by flow cytometry using human leukocyte antigen (HLA) class I pentamers. Flow-sorted HO-1-specific CD8 T cells were cultured and tested for suppressive activity on HIV-1-specific cytotoxic T-cell clones clones. HO-1 gene expression was determined in sorted peripheral blood mononuclear cell (PBMC) subsets from individuals with acute HIV-1 infection.RESULTS: HO-1 plasma levels were significantly increased in HIV-1 infection, with the highest levels in individuals with acute HIV-1 infection, and gradually declined over time. The frequency of CD8 T cells specific for HO-1 was elevated in study participants with primary HIV-1 infection and flow-sorted HO-1-specific CD8 T cells were capable of suppressing HIV-1-specific lysis of cytotoxic T-cell clones clones. HO-1 gene expression was upregulated in multiple immune cell subsets during acute HIV-1 infection and HO-1 overexpression modulated anti-HIV immunity in vitro.CONCLUSION: Our data suggest that HO-1 is induced during acute HIV-1 infection, likely mediating anti-inflammatory effects and driving expansion of HO-1-specific CD8 regulatory T cells capable of suppressing HIV-1-specific immune responses in vitro. The investigation of HO-1 and the novel CD8 regulatory cell type described here provide further insight into immune regulation in HIV-1 infection and may hold potential for future immunotherapeutic intervention.

AB - OBJECTIVE: Heme oxygenase-1 (HO-1) is an inducible stress response protein with potent anti-inflammatory activity and recent data suggest a potentially beneficial role in HIV pathogenesis. We investigated the impact of HO-1 and a novel subset of HO-1-specific CD8 regulatory T cells on virus-specific T-cell immunity in HIV-1-infected individuals.METHODS: HO-1 protein levels were quantified in plasma from individuals at different stages of HIV-1 disease and longitudinally following primary HIV infection. HO-1-specific CD8 T cells were investigated by flow cytometry using human leukocyte antigen (HLA) class I pentamers. Flow-sorted HO-1-specific CD8 T cells were cultured and tested for suppressive activity on HIV-1-specific cytotoxic T-cell clones clones. HO-1 gene expression was determined in sorted peripheral blood mononuclear cell (PBMC) subsets from individuals with acute HIV-1 infection.RESULTS: HO-1 plasma levels were significantly increased in HIV-1 infection, with the highest levels in individuals with acute HIV-1 infection, and gradually declined over time. The frequency of CD8 T cells specific for HO-1 was elevated in study participants with primary HIV-1 infection and flow-sorted HO-1-specific CD8 T cells were capable of suppressing HIV-1-specific lysis of cytotoxic T-cell clones clones. HO-1 gene expression was upregulated in multiple immune cell subsets during acute HIV-1 infection and HO-1 overexpression modulated anti-HIV immunity in vitro.CONCLUSION: Our data suggest that HO-1 is induced during acute HIV-1 infection, likely mediating anti-inflammatory effects and driving expansion of HO-1-specific CD8 regulatory T cells capable of suppressing HIV-1-specific immune responses in vitro. The investigation of HO-1 and the novel CD8 regulatory cell type described here provide further insight into immune regulation in HIV-1 infection and may hold potential for future immunotherapeutic intervention.

KW - CD8-Positive T-Lymphocytes

KW - Cells, Cultured

KW - Flow Cytometry

KW - HIV Infections

KW - HIV-1

KW - Heme Oxygenase-1

KW - Humans

KW - Immunophenotyping

KW - Longitudinal Studies

KW - Plasma

KW - T-Lymphocytes, Regulatory

KW - Journal Article

U2 - 10.1097/QAD.0000000000001390

DO - 10.1097/QAD.0000000000001390

M3 - SCORING: Journal article

C2 - 28060008

VL - 31

SP - 635

EP - 641

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 5

ER -