Acute cerebrovascular disease in the Young: the Stroke in Young Fabry Patients study
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Acute cerebrovascular disease in the Young: the Stroke in Young Fabry Patients study. / Rolfs, Arndt; Fazekas, Franz; Grittner, Ulrike; Dichgans, Martin; Martus, Peter; Holzhausen, Martin; Böttcher, Tobias; Heuschmann, Peter U; Tatlisumak, Turgut; Tanislav, Christian; Jungehulsing, Gerhard J; Giese, Anne-Katrin; Putaala, Jukaa; Huber, Roman; Bodechtel, Ulf; Lichy, Christoph; Enzinger, Christian; Schmidt, Reinhold; Hennerici, Michael G; Kaps, Manfred; Kessler, Christof; Lackner, Karl; Paschke, Eduard; Meyer, Wolfgang; Mascher, Hermann; Riess, Olaf; Kolodny, Edwin; Norrving, Bo; Stroke in Young Fabry Patients (sifap) Investigators.
in: STROKE, Jahrgang 44, Nr. 2, 01.02.2013, S. 340-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Acute cerebrovascular disease in the Young: the Stroke in Young Fabry Patients study
AU - Rolfs, Arndt
AU - Fazekas, Franz
AU - Grittner, Ulrike
AU - Dichgans, Martin
AU - Martus, Peter
AU - Holzhausen, Martin
AU - Böttcher, Tobias
AU - Heuschmann, Peter U
AU - Tatlisumak, Turgut
AU - Tanislav, Christian
AU - Jungehulsing, Gerhard J
AU - Giese, Anne-Katrin
AU - Putaala, Jukaa
AU - Huber, Roman
AU - Bodechtel, Ulf
AU - Lichy, Christoph
AU - Enzinger, Christian
AU - Schmidt, Reinhold
AU - Hennerici, Michael G
AU - Kaps, Manfred
AU - Kessler, Christof
AU - Lackner, Karl
AU - Paschke, Eduard
AU - Meyer, Wolfgang
AU - Mascher, Hermann
AU - Riess, Olaf
AU - Kolodny, Edwin
AU - Norrving, Bo
AU - Stroke in Young Fabry Patients (sifap) Investigators
AU - Choe, Chi-un
PY - 2013/2/1
Y1 - 2013/2/1
N2 - BACKGROUND AND PURPOSE: Strokes have especially devastating implications if they occur early in life; however, only limited information exists on the characteristics of acute cerebrovascular disease in young adults. Although risk factors and manifestation of atherosclerosis are commonly associated with stroke in the elderly, recent data suggests different causes for stroke in the young. We initiated the prospective, multinational European study Stroke in Young Fabry Patients (sifap) to characterize a cohort of young stroke patients.METHODS: Overall, 5023 patients aged 18 to 55 years with the diagnosis of ischemic stroke (3396), hemorrhagic stroke (271), transient ischemic attack (1071) were enrolled in 15 European countries and 47 centers between April 2007 and January 2010 undergoing a detailed, standardized, clinical, laboratory, and radiological protocol.RESULTS: Median age in the overall cohort was 46 years. Definite Fabry disease was diagnosed in 0.5% (95% confidence interval, 0.4%-0.8%; n=27) of all patients; and probable Fabry disease in additional 18 patients. Males dominated the study population (2962/59%) whereas females outnumbered men (65.3%) among the youngest patients (18-24 years). About 80.5% of the patients had a first stroke. Silent infarcts on magnetic resonance imaging were seen in 20% of patients with a first-ever stroke, and in 11.4% of patients with transient ischemic attack and no history of a previous cerebrovascular event. The most common causes of ischemic stroke were large artery atherosclerosis (18.6%) and dissection (9.9%).CONCLUSIONS: Definite Fabry disease occurs in 0.5% and probable Fabry disease in further 0.4% of young stroke patients. Silent infarcts, white matter intensities, and classical risk factors were highly prevalent, emphasizing the need for new early preventive strategies. Clinical Trial Registration Information- URL: http://www.clinicaltrials.gov.Unique identifier: NCT00414583.
AB - BACKGROUND AND PURPOSE: Strokes have especially devastating implications if they occur early in life; however, only limited information exists on the characteristics of acute cerebrovascular disease in young adults. Although risk factors and manifestation of atherosclerosis are commonly associated with stroke in the elderly, recent data suggests different causes for stroke in the young. We initiated the prospective, multinational European study Stroke in Young Fabry Patients (sifap) to characterize a cohort of young stroke patients.METHODS: Overall, 5023 patients aged 18 to 55 years with the diagnosis of ischemic stroke (3396), hemorrhagic stroke (271), transient ischemic attack (1071) were enrolled in 15 European countries and 47 centers between April 2007 and January 2010 undergoing a detailed, standardized, clinical, laboratory, and radiological protocol.RESULTS: Median age in the overall cohort was 46 years. Definite Fabry disease was diagnosed in 0.5% (95% confidence interval, 0.4%-0.8%; n=27) of all patients; and probable Fabry disease in additional 18 patients. Males dominated the study population (2962/59%) whereas females outnumbered men (65.3%) among the youngest patients (18-24 years). About 80.5% of the patients had a first stroke. Silent infarcts on magnetic resonance imaging were seen in 20% of patients with a first-ever stroke, and in 11.4% of patients with transient ischemic attack and no history of a previous cerebrovascular event. The most common causes of ischemic stroke were large artery atherosclerosis (18.6%) and dissection (9.9%).CONCLUSIONS: Definite Fabry disease occurs in 0.5% and probable Fabry disease in further 0.4% of young stroke patients. Silent infarcts, white matter intensities, and classical risk factors were highly prevalent, emphasizing the need for new early preventive strategies. Clinical Trial Registration Information- URL: http://www.clinicaltrials.gov.Unique identifier: NCT00414583.
KW - Acute Disease
KW - Adolescent
KW - Adult
KW - Age Factors
KW - Cerebrovascular Disorders
KW - Cohort Studies
KW - Europe
KW - Fabry Disease
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Prospective Studies
KW - Risk Factors
KW - Stroke
KW - Young Adult
U2 - 10.1161/STROKEAHA.112.663708
DO - 10.1161/STROKEAHA.112.663708
M3 - SCORING: Journal article
C2 - 23306324
VL - 44
SP - 340
EP - 349
JO - STROKE
JF - STROKE
SN - 0039-2499
IS - 2
ER -
