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Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks.

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Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. / Alberi, Lavinia; Liu, Shuxi; Wang, Yue; Badie, Ramy; Smith-Hicks, Constance; Wu, Jing; Pierfelice, Tarran J; Abazyan, Bagrat; Mattson, Mark P; Kuhl, Dietmar; Pletnikov, Mikhail; Worley, Paul F; Gaiano, Nicholas.

in: NEURON, Jahrgang 69, Nr. 3, 3, 2011, S. 437-444.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Alberi, L, Liu, S, Wang, Y, Badie, R, Smith-Hicks, C, Wu, J, Pierfelice, TJ, Abazyan, B, Mattson, MP, Kuhl, D, Pletnikov, M, Worley, PF & Gaiano, N 2011, 'Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks.', NEURON, Jg. 69, Nr. 3, 3, S. 437-444. <http://www.ncbi.nlm.nih.gov/pubmed/21315255?dopt=Citation>

APA

Alberi, L., Liu, S., Wang, Y., Badie, R., Smith-Hicks, C., Wu, J., Pierfelice, T. J., Abazyan, B., Mattson, M. P., Kuhl, D., Pletnikov, M., Worley, P. F., & Gaiano, N. (2011). Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. NEURON, 69(3), 437-444. [3]. http://www.ncbi.nlm.nih.gov/pubmed/21315255?dopt=Citation

Vancouver

Alberi L, Liu S, Wang Y, Badie R, Smith-Hicks C, Wu J et al. Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. NEURON. 2011;69(3):437-444. 3.

Bibtex

@article{8e8464b923724182a30da4165617c934,
title = "Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks.",
abstract = "Notch signaling in the nervous system has been most studied in the context of cell fate specification. However, numerous studies have suggested that Notch also regulates neuronal morphology, synaptic plasticity, learning, and memory. Here we show that Notch1 and its ligand Jagged1 are present at the synapse, and that Notch signaling in neurons occurs in response to synaptic activity. In addition, neuronal Notch signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity. In Arc/Arg3.1 mutant neurons, the proteolytic activation of Notch1 is disrupted both in vivo and in vitro. Conditional deletion of Notch1 in the postnatal hippocampus disrupted both long-term potentiation (LTP) and long-term depression (LTD), and led to deficits in learning and short-term memory. Thus, Notch signaling is dynamically regulated in response to neuronal activity, Arc/Arg3.1 is a context-dependent Notch regulator, and Notch1 is required for the synaptic plasticity that contributes to memory formation.",
keywords = "Animals, Cells, Cultured, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Neurologic Mutants, Neuronal Plasticity/*physiology, Mice, 129 Strain, Hippocampus/*physiology, Signal Transduction/*physiology, Cytoskeletal Proteins/*physiology, Maze Learning/physiology, Nerve Net/*physiology, Nerve Tissue Proteins/*physiology, Neurons/physiology, Receptor, Notch1/*physiology, Synapses/physiology, Animals, Cells, Cultured, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Neurologic Mutants, Neuronal Plasticity/*physiology, Mice, 129 Strain, Hippocampus/*physiology, Signal Transduction/*physiology, Cytoskeletal Proteins/*physiology, Maze Learning/physiology, Nerve Net/*physiology, Nerve Tissue Proteins/*physiology, Neurons/physiology, Receptor, Notch1/*physiology, Synapses/physiology",
author = "Lavinia Alberi and Shuxi Liu and Yue Wang and Ramy Badie and Constance Smith-Hicks and Jing Wu and Pierfelice, {Tarran J} and Bagrat Abazyan and Mattson, {Mark P} and Dietmar Kuhl and Mikhail Pletnikov and Worley, {Paul F} and Nicholas Gaiano",
year = "2011",
language = "English",
volume = "69",
pages = "437--444",
journal = "NEURON",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks.

AU - Alberi, Lavinia

AU - Liu, Shuxi

AU - Wang, Yue

AU - Badie, Ramy

AU - Smith-Hicks, Constance

AU - Wu, Jing

AU - Pierfelice, Tarran J

AU - Abazyan, Bagrat

AU - Mattson, Mark P

AU - Kuhl, Dietmar

AU - Pletnikov, Mikhail

AU - Worley, Paul F

AU - Gaiano, Nicholas

PY - 2011

Y1 - 2011

N2 - Notch signaling in the nervous system has been most studied in the context of cell fate specification. However, numerous studies have suggested that Notch also regulates neuronal morphology, synaptic plasticity, learning, and memory. Here we show that Notch1 and its ligand Jagged1 are present at the synapse, and that Notch signaling in neurons occurs in response to synaptic activity. In addition, neuronal Notch signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity. In Arc/Arg3.1 mutant neurons, the proteolytic activation of Notch1 is disrupted both in vivo and in vitro. Conditional deletion of Notch1 in the postnatal hippocampus disrupted both long-term potentiation (LTP) and long-term depression (LTD), and led to deficits in learning and short-term memory. Thus, Notch signaling is dynamically regulated in response to neuronal activity, Arc/Arg3.1 is a context-dependent Notch regulator, and Notch1 is required for the synaptic plasticity that contributes to memory formation.

AB - Notch signaling in the nervous system has been most studied in the context of cell fate specification. However, numerous studies have suggested that Notch also regulates neuronal morphology, synaptic plasticity, learning, and memory. Here we show that Notch1 and its ligand Jagged1 are present at the synapse, and that Notch signaling in neurons occurs in response to synaptic activity. In addition, neuronal Notch signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity. In Arc/Arg3.1 mutant neurons, the proteolytic activation of Notch1 is disrupted both in vivo and in vitro. Conditional deletion of Notch1 in the postnatal hippocampus disrupted both long-term potentiation (LTP) and long-term depression (LTD), and led to deficits in learning and short-term memory. Thus, Notch signaling is dynamically regulated in response to neuronal activity, Arc/Arg3.1 is a context-dependent Notch regulator, and Notch1 is required for the synaptic plasticity that contributes to memory formation.

KW - Animals

KW - Cells, Cultured

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Mice, Neurologic Mutants

KW - Neuronal Plasticity/physiology

KW - Mice, 129 Strain

KW - Hippocampus/physiology

KW - Signal Transduction/physiology

KW - Cytoskeletal Proteins/physiology

KW - Maze Learning/physiology

KW - Nerve Net/physiology

KW - Nerve Tissue Proteins/physiology

KW - Neurons/physiology

KW - Receptor, Notch1/physiology

KW - Synapses/physiology

KW - Animals

KW - Cells, Cultured

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Mice, Neurologic Mutants

KW - Neuronal Plasticity/physiology

KW - Mice, 129 Strain

KW - Hippocampus/physiology

KW - Signal Transduction/physiology

KW - Cytoskeletal Proteins/physiology

KW - Maze Learning/physiology

KW - Nerve Net/physiology

KW - Nerve Tissue Proteins/physiology

KW - Neurons/physiology

KW - Receptor, Notch1/physiology

KW - Synapses/physiology

M3 - SCORING: Journal article

VL - 69

SP - 437

EP - 444

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 3

M1 - 3

ER -