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Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

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Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. / Hakkim, Abdul; Fuchs, Tobias A; Martinez, Nancy E; Hess, Simone; Prinz, Heino; Zychlinsky, Arturo; Waldmann, Herbert.

in: NAT CHEM BIOL, Jahrgang 7, Nr. 2, 01.02.2011, S. 75-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hakkim, A, Fuchs, TA, Martinez, NE, Hess, S, Prinz, H, Zychlinsky, A & Waldmann, H 2011, 'Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation', NAT CHEM BIOL, Jg. 7, Nr. 2, S. 75-7. https://doi.org/10.1038/nchembio.496

APA

Hakkim, A., Fuchs, T. A., Martinez, N. E., Hess, S., Prinz, H., Zychlinsky, A., & Waldmann, H. (2011). Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. NAT CHEM BIOL, 7(2), 75-7. https://doi.org/10.1038/nchembio.496

Vancouver

Hakkim A, Fuchs TA, Martinez NE, Hess S, Prinz H, Zychlinsky A et al. Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. NAT CHEM BIOL. 2011 Feb 1;7(2):75-7. https://doi.org/10.1038/nchembio.496

Bibtex

@article{96ce9004de964dd29f10bdb86158d8c9,
title = "Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation",
abstract = "The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly understood. Neutrophils are not amenable to studies with conventional genetic techniques. Using a new chemical genetic analysis we show that the Raf-MEK-ERK pathway is involved in NET formation through activation of NADPH oxidase and upregulation of antiapoptotic proteins. We identify potential targets for drugs addressing NET-associated diseases.",
keywords = "Extracellular Signal-Regulated MAP Kinases, Humans, MAP Kinase Kinase Kinases, Neutrophils",
author = "Abdul Hakkim and Fuchs, {Tobias A} and Martinez, {Nancy E} and Simone Hess and Heino Prinz and Arturo Zychlinsky and Herbert Waldmann",
year = "2011",
month = feb,
day = "1",
doi = "10.1038/nchembio.496",
language = "English",
volume = "7",
pages = "75--7",
journal = "NAT CHEM BIOL",
issn = "1552-4450",
publisher = "NATURE PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

AU - Hakkim, Abdul

AU - Fuchs, Tobias A

AU - Martinez, Nancy E

AU - Hess, Simone

AU - Prinz, Heino

AU - Zychlinsky, Arturo

AU - Waldmann, Herbert

PY - 2011/2/1

Y1 - 2011/2/1

N2 - The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly understood. Neutrophils are not amenable to studies with conventional genetic techniques. Using a new chemical genetic analysis we show that the Raf-MEK-ERK pathway is involved in NET formation through activation of NADPH oxidase and upregulation of antiapoptotic proteins. We identify potential targets for drugs addressing NET-associated diseases.

AB - The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly understood. Neutrophils are not amenable to studies with conventional genetic techniques. Using a new chemical genetic analysis we show that the Raf-MEK-ERK pathway is involved in NET formation through activation of NADPH oxidase and upregulation of antiapoptotic proteins. We identify potential targets for drugs addressing NET-associated diseases.

KW - Extracellular Signal-Regulated MAP Kinases

KW - Humans

KW - MAP Kinase Kinase Kinases

KW - Neutrophils

U2 - 10.1038/nchembio.496

DO - 10.1038/nchembio.496

M3 - SCORING: Journal article

C2 - 21170021

VL - 7

SP - 75

EP - 77

JO - NAT CHEM BIOL

JF - NAT CHEM BIOL

SN - 1552-4450

IS - 2

ER -