Acetaminophen and pregnancy: short- and long-term consequences for mother and child

Kristin Thiele; Timo Kessler; Petra Arck; Annette Erhardt; Gisa Tiegs

doi:10.1016/j.jri.2012.10.014

Acetaminophen and pregnancy: short- and long-term consequences for mother and child

Standard

Acetaminophen and pregnancy: short- and long-term consequences for mother and child. / Thiele, Kristin; Kessler, Timo; Arck, Petra; Erhardt, Annette; Tiegs, Gisa.

in: J REPROD IMMUNOL, Jahrgang 97, Nr. 1, 01.03.2013, S. 128-39.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Thiele, K, Kessler, T, Arck, P, Erhardt, A & Tiegs, G 2013, 'Acetaminophen and pregnancy: short- and long-term consequences for mother and child', J REPROD IMMUNOL, Jg. 97, Nr. 1, S. 128-39. https://doi.org/10.1016/j.jri.2012.10.014

APA

Thiele, K., Kessler, T., Arck, P., Erhardt, A., & Tiegs, G. (2013). Acetaminophen and pregnancy: short- and long-term consequences for mother and child. J REPROD IMMUNOL, 97(1), 128-39. https://doi.org/10.1016/j.jri.2012.10.014

Vancouver

Thiele K, Kessler T, Arck P, Erhardt A, Tiegs G. Acetaminophen and pregnancy: short- and long-term consequences for mother and child. J REPROD IMMUNOL. 2013 Mär 1;97(1):128-39. https://doi.org/10.1016/j.jri.2012.10.014

Bibtex

@article{9d37b4262a374a6ca8ed445683204bb0,

title = "Acetaminophen and pregnancy: short- and long-term consequences for mother and child",

abstract = "Counter-intuitively, over-the-counter medication is commonly taken by pregnant women. In this context, acetaminophen (APAP, e.g. Paracetamol, Tylenol) is generally recommended by physicians to treat fever and pain during pregnancy. Thus, APAP ranks at the top of the list of medications taken prenatally. Insights on an increased risk for pregnancy complications such as miscarriage, stillbirth, preterm birth or fetal malformations upon APAP exposure are rather ambiguous. However, emerging evidence arising from human trials clearly reveals a significant correlation between APAP use during pregnancy and an increased risk for the development of asthma in children later in life. Pathways through which APAP increases this risk are still elusive. APAP can be liver toxic and since APAP appears to freely cross the placenta, therapeutic and certainly toxic doses could not only affect maternal, but also fetal hepatocytes. It is noteworthy that during fetal development, the liver transiently functions as the main hematopoietic organ. We here review the effect of APAP on metabolic and immunological parameters in pregnant women and on fetal development and immune ontogeny in order to delineate novel, putative and to date underrated pathways through which APAP use during pregnancy can impair maternal, fetal and long term children's health. We conclude that future studies are urgently needed to reconsider the safety and dosage of APAP during pregnancy and - based on the advances made in the field of reproduction as well as APAP metabolism - we propose pathways, which should be addressed in future research and clinical endeavors.",

keywords = "Acetaminophen, Antipyretics, Child, Female, Fetal Development, Fetus, Humans, Liver, Maternal Exposure, Mothers, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects",

author = "Kristin Thiele and Timo Kessler and Petra Arck and Annette Erhardt and Gisa Tiegs",

year = "2013",

month = mar,

day = "1",

doi = "10.1016/j.jri.2012.10.014",

language = "English",

volume = "97",

pages = "128--39",

journal = "J REPROD IMMUNOL",

issn = "0165-0378",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

RIS

TY - JOUR

T1 - Acetaminophen and pregnancy: short- and long-term consequences for mother and child

AU - Thiele, Kristin

AU - Kessler, Timo

AU - Arck, Petra

AU - Erhardt, Annette

AU - Tiegs, Gisa

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Counter-intuitively, over-the-counter medication is commonly taken by pregnant women. In this context, acetaminophen (APAP, e.g. Paracetamol, Tylenol) is generally recommended by physicians to treat fever and pain during pregnancy. Thus, APAP ranks at the top of the list of medications taken prenatally. Insights on an increased risk for pregnancy complications such as miscarriage, stillbirth, preterm birth or fetal malformations upon APAP exposure are rather ambiguous. However, emerging evidence arising from human trials clearly reveals a significant correlation between APAP use during pregnancy and an increased risk for the development of asthma in children later in life. Pathways through which APAP increases this risk are still elusive. APAP can be liver toxic and since APAP appears to freely cross the placenta, therapeutic and certainly toxic doses could not only affect maternal, but also fetal hepatocytes. It is noteworthy that during fetal development, the liver transiently functions as the main hematopoietic organ. We here review the effect of APAP on metabolic and immunological parameters in pregnant women and on fetal development and immune ontogeny in order to delineate novel, putative and to date underrated pathways through which APAP use during pregnancy can impair maternal, fetal and long term children's health. We conclude that future studies are urgently needed to reconsider the safety and dosage of APAP during pregnancy and - based on the advances made in the field of reproduction as well as APAP metabolism - we propose pathways, which should be addressed in future research and clinical endeavors.

AB - Counter-intuitively, over-the-counter medication is commonly taken by pregnant women. In this context, acetaminophen (APAP, e.g. Paracetamol, Tylenol) is generally recommended by physicians to treat fever and pain during pregnancy. Thus, APAP ranks at the top of the list of medications taken prenatally. Insights on an increased risk for pregnancy complications such as miscarriage, stillbirth, preterm birth or fetal malformations upon APAP exposure are rather ambiguous. However, emerging evidence arising from human trials clearly reveals a significant correlation between APAP use during pregnancy and an increased risk for the development of asthma in children later in life. Pathways through which APAP increases this risk are still elusive. APAP can be liver toxic and since APAP appears to freely cross the placenta, therapeutic and certainly toxic doses could not only affect maternal, but also fetal hepatocytes. It is noteworthy that during fetal development, the liver transiently functions as the main hematopoietic organ. We here review the effect of APAP on metabolic and immunological parameters in pregnant women and on fetal development and immune ontogeny in order to delineate novel, putative and to date underrated pathways through which APAP use during pregnancy can impair maternal, fetal and long term children's health. We conclude that future studies are urgently needed to reconsider the safety and dosage of APAP during pregnancy and - based on the advances made in the field of reproduction as well as APAP metabolism - we propose pathways, which should be addressed in future research and clinical endeavors.

KW - Acetaminophen

KW - Antipyretics

KW - Child

KW - Female

KW - Fetal Development

KW - Fetus

KW - Humans

KW - Liver

KW - Maternal Exposure

KW - Mothers

KW - Pregnancy

KW - Pregnancy Complications

KW - Prenatal Exposure Delayed Effects

U2 - 10.1016/j.jri.2012.10.014

DO - 10.1016/j.jri.2012.10.014

M3 - SCORING: Journal article

C2 - 23432879

VL - 97

SP - 128

EP - 139

JO - J REPROD IMMUNOL

JF - J REPROD IMMUNOL

SN - 0165-0378

IS - 1

ER -