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Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy

Standard

Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy. / Lonati, Chiara; Baumeister, Philipp; Ornaghi, Paola Irene; Di Trapani, Ettore; De Cobelli, Ottavio; Rink, Michael; Karnes, Robert Jeffrey; Poyet, Cédric; Simone, Giuseppe; Afferi, Luca; Necchi, Andrea; Briganti, Alberto; Montorsi, Francesco; Krajewski, Wojciech; Antonelli, Alessandro; Cerruto, Maria Angela; Zamboni, Stefania; Simeone, Claudio; Mordasini, Livio; Mattei, Agostino; Moschini, Marco; EAU-YAU Urothelial Cancer Working Party.

in: EUR UROL FOCUS, Jahrgang 8, Nr. 2, 03.2022, S. 457-464.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lonati, C, Baumeister, P, Ornaghi, PI, Di Trapani, E, De Cobelli, O, Rink, M, Karnes, RJ, Poyet, C, Simone, G, Afferi, L, Necchi, A, Briganti, A, Montorsi, F, Krajewski, W, Antonelli, A, Cerruto, MA, Zamboni, S, Simeone, C, Mordasini, L, Mattei, A, Moschini, M & EAU-YAU Urothelial Cancer Working Party 2022, 'Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy', EUR UROL FOCUS, Jg. 8, Nr. 2, S. 457-464. https://doi.org/10.1016/j.euf.2021.04.005

APA

Lonati, C., Baumeister, P., Ornaghi, P. I., Di Trapani, E., De Cobelli, O., Rink, M., Karnes, R. J., Poyet, C., Simone, G., Afferi, L., Necchi, A., Briganti, A., Montorsi, F., Krajewski, W., Antonelli, A., Cerruto, M. A., Zamboni, S., Simeone, C., Mordasini, L., ... EAU-YAU Urothelial Cancer Working Party (2022). Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy. EUR UROL FOCUS, 8(2), 457-464. https://doi.org/10.1016/j.euf.2021.04.005

Vancouver

Lonati C, Baumeister P, Ornaghi PI, Di Trapani E, De Cobelli O, Rink M et al. Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy. EUR UROL FOCUS. 2022 Mär;8(2):457-464. https://doi.org/10.1016/j.euf.2021.04.005

Bibtex

@article{87810fac3d644a709c346b1dda7acc18,
title = "Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy",
abstract = "BACKGROUND: Correct identification of variant histologies (VHs) of bladder cancer (BCa) at transurethral resection of the bladder (TURB) could drive the subsequent treatment.OBJECTIVE: To evaluate the concordance in detecting VHs between TURB and radical cystectomy (RC) specimens in BCa patients.DESIGN, SETTING, AND PARTICIPANTS: We retrospectively analyzed 1881 BCa patients who underwent TURB and subsequent RC at seven tertiary care centers between 1980 and 2018. VHs were classified as sarcomatoid, lymphoepithelioma-like, neuroendocrine, squamous, micropapillary, glandular, adenocarcinoma, nested, and other variants.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Concordance between TURB and RC was defined as the ability to achieve histological subtypes at TURB confirmed at RC specimen, and was expressed according to Cohen's kappa coefficient.RESULTS AND LIMITATIONS: Of the patients, 14.6% and 21% were diagnosed with VH at TURB and RC specimens, respectively. The most common VHs at TURB were squamous, neuroendocrine, and micropapillary carcinoma (5.2%, 1.5%, and 1.5%, respectively). At RC, the most frequent VHs were squamous, micropapillary, and sarcomatoid carcinoma (7.2%, 3.0%, and 2.7%, respectively). The overall concordance in detecting VH was defined as slight concordance (coefficient: 0.18). Moderate concordance was found for neuroendocrine, adenocarcinoma, and squamous carcinoma (coefficient: 0.49, 0.47, and 0.41, respectively). Micropapillary, glandular, and other variants showed slight concordance (coefficient: 0.05, 0.17, and 0.12, respectively), while nested and sarcomatoid carcinoma showed fair concordance (coefficient: 0.32 and 0.26, respectively). Results may be limited by the absence of centralized pathological analysis.CONCLUSIONS: A non-negligible percentage of patients were diagnosed with VH at both TURB and RC. TURB showed relatively low accuracy, ranging from poor to moderate, in detecting VHs. Our study underlines the need of additional diagnostic tools in order to identify VHs properly at precystectomy time and to improve patient survival outcomes.PATIENT SUMMARY: In this report, we underlined the low accuracy of transurethral resection of the bladder in detecting variant histologies and the need for additional diagnostic tools.",
author = "Chiara Lonati and Philipp Baumeister and Ornaghi, {Paola Irene} and {Di Trapani}, Ettore and {De Cobelli}, Ottavio and Michael Rink and Karnes, {Robert Jeffrey} and C{\'e}dric Poyet and Giuseppe Simone and Luca Afferi and Andrea Necchi and Alberto Briganti and Francesco Montorsi and Wojciech Krajewski and Alessandro Antonelli and Cerruto, {Maria Angela} and Stefania Zamboni and Claudio Simeone and Livio Mordasini and Agostino Mattei and Marco Moschini and {EAU-YAU Urothelial Cancer Working Party}",
note = "Copyright {\textcopyright} 2021 European Association of Urology. Published by Elsevier B.V. All rights reserved.",
year = "2022",
month = mar,
doi = "10.1016/j.euf.2021.04.005",
language = "English",
volume = "8",
pages = "457--464",
journal = "EUR UROL FOCUS",
issn = "2405-4569",
publisher = "Elsevier BV",
number = "2",

}

RIS

TY - JOUR

T1 - Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy

AU - Lonati, Chiara

AU - Baumeister, Philipp

AU - Ornaghi, Paola Irene

AU - Di Trapani, Ettore

AU - De Cobelli, Ottavio

AU - Rink, Michael

AU - Karnes, Robert Jeffrey

AU - Poyet, Cédric

AU - Simone, Giuseppe

AU - Afferi, Luca

AU - Necchi, Andrea

AU - Briganti, Alberto

AU - Montorsi, Francesco

AU - Krajewski, Wojciech

AU - Antonelli, Alessandro

AU - Cerruto, Maria Angela

AU - Zamboni, Stefania

AU - Simeone, Claudio

AU - Mordasini, Livio

AU - Mattei, Agostino

AU - Moschini, Marco

AU - EAU-YAU Urothelial Cancer Working Party

N1 - Copyright © 2021 European Association of Urology. Published by Elsevier B.V. All rights reserved.

PY - 2022/3

Y1 - 2022/3

N2 - BACKGROUND: Correct identification of variant histologies (VHs) of bladder cancer (BCa) at transurethral resection of the bladder (TURB) could drive the subsequent treatment.OBJECTIVE: To evaluate the concordance in detecting VHs between TURB and radical cystectomy (RC) specimens in BCa patients.DESIGN, SETTING, AND PARTICIPANTS: We retrospectively analyzed 1881 BCa patients who underwent TURB and subsequent RC at seven tertiary care centers between 1980 and 2018. VHs were classified as sarcomatoid, lymphoepithelioma-like, neuroendocrine, squamous, micropapillary, glandular, adenocarcinoma, nested, and other variants.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Concordance between TURB and RC was defined as the ability to achieve histological subtypes at TURB confirmed at RC specimen, and was expressed according to Cohen's kappa coefficient.RESULTS AND LIMITATIONS: Of the patients, 14.6% and 21% were diagnosed with VH at TURB and RC specimens, respectively. The most common VHs at TURB were squamous, neuroendocrine, and micropapillary carcinoma (5.2%, 1.5%, and 1.5%, respectively). At RC, the most frequent VHs were squamous, micropapillary, and sarcomatoid carcinoma (7.2%, 3.0%, and 2.7%, respectively). The overall concordance in detecting VH was defined as slight concordance (coefficient: 0.18). Moderate concordance was found for neuroendocrine, adenocarcinoma, and squamous carcinoma (coefficient: 0.49, 0.47, and 0.41, respectively). Micropapillary, glandular, and other variants showed slight concordance (coefficient: 0.05, 0.17, and 0.12, respectively), while nested and sarcomatoid carcinoma showed fair concordance (coefficient: 0.32 and 0.26, respectively). Results may be limited by the absence of centralized pathological analysis.CONCLUSIONS: A non-negligible percentage of patients were diagnosed with VH at both TURB and RC. TURB showed relatively low accuracy, ranging from poor to moderate, in detecting VHs. Our study underlines the need of additional diagnostic tools in order to identify VHs properly at precystectomy time and to improve patient survival outcomes.PATIENT SUMMARY: In this report, we underlined the low accuracy of transurethral resection of the bladder in detecting variant histologies and the need for additional diagnostic tools.

AB - BACKGROUND: Correct identification of variant histologies (VHs) of bladder cancer (BCa) at transurethral resection of the bladder (TURB) could drive the subsequent treatment.OBJECTIVE: To evaluate the concordance in detecting VHs between TURB and radical cystectomy (RC) specimens in BCa patients.DESIGN, SETTING, AND PARTICIPANTS: We retrospectively analyzed 1881 BCa patients who underwent TURB and subsequent RC at seven tertiary care centers between 1980 and 2018. VHs were classified as sarcomatoid, lymphoepithelioma-like, neuroendocrine, squamous, micropapillary, glandular, adenocarcinoma, nested, and other variants.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Concordance between TURB and RC was defined as the ability to achieve histological subtypes at TURB confirmed at RC specimen, and was expressed according to Cohen's kappa coefficient.RESULTS AND LIMITATIONS: Of the patients, 14.6% and 21% were diagnosed with VH at TURB and RC specimens, respectively. The most common VHs at TURB were squamous, neuroendocrine, and micropapillary carcinoma (5.2%, 1.5%, and 1.5%, respectively). At RC, the most frequent VHs were squamous, micropapillary, and sarcomatoid carcinoma (7.2%, 3.0%, and 2.7%, respectively). The overall concordance in detecting VH was defined as slight concordance (coefficient: 0.18). Moderate concordance was found for neuroendocrine, adenocarcinoma, and squamous carcinoma (coefficient: 0.49, 0.47, and 0.41, respectively). Micropapillary, glandular, and other variants showed slight concordance (coefficient: 0.05, 0.17, and 0.12, respectively), while nested and sarcomatoid carcinoma showed fair concordance (coefficient: 0.32 and 0.26, respectively). Results may be limited by the absence of centralized pathological analysis.CONCLUSIONS: A non-negligible percentage of patients were diagnosed with VH at both TURB and RC. TURB showed relatively low accuracy, ranging from poor to moderate, in detecting VHs. Our study underlines the need of additional diagnostic tools in order to identify VHs properly at precystectomy time and to improve patient survival outcomes.PATIENT SUMMARY: In this report, we underlined the low accuracy of transurethral resection of the bladder in detecting variant histologies and the need for additional diagnostic tools.

U2 - 10.1016/j.euf.2021.04.005

DO - 10.1016/j.euf.2021.04.005

M3 - SCORING: Journal article

C2 - 33867307

VL - 8

SP - 457

EP - 464

JO - EUR UROL FOCUS

JF - EUR UROL FOCUS

SN - 2405-4569

IS - 2

ER -