Accuracy of life tables in predicting overall survival in candidates for radiotherapy for prostate cancer.
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Accuracy of life tables in predicting overall survival in candidates for radiotherapy for prostate cancer. / Walz, Jochen; Gallina, Andrea; Hutterer, Georg; Perrotte, Paul; Shariat, Shahrokh F; Graefen, Markus; McCormack, Michael; Bénard, Francois; Valiquette, Luc; Saad, Fred; Karakiewicz, Pierre I.
in: INT J RADIAT ONCOL, Jahrgang 69, Nr. 1, 1, 2007, S. 88-94.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Accuracy of life tables in predicting overall survival in candidates for radiotherapy for prostate cancer.
AU - Walz, Jochen
AU - Gallina, Andrea
AU - Hutterer, Georg
AU - Perrotte, Paul
AU - Shariat, Shahrokh F
AU - Graefen, Markus
AU - McCormack, Michael
AU - Bénard, Francois
AU - Valiquette, Luc
AU - Saad, Fred
AU - Karakiewicz, Pierre I
PY - 2007
Y1 - 2007
N2 - PURPOSE: To test the accuracy of life tables (LTs) in predicting survival in men treated with radiotherapy for localized prostate cancer. METHODS AND MATERIALS: We selected the records of 3,176 patients treated with radiotherapy and who had no clinical evidence of disease relapse. Life table-derived life expectancy (LE) was defined for every individual using a population-specific LT. Age, Charlson Comorbidity Index (CCI), and LT-derived LE were then used as predictors of overall mortality in Cox regression models. Predictive accuracy (PA) was estimated with the Harrell's concordance index and was internally validated with 200 bootstrap resamples. RESULTS: The actuarial median survival was 4.7 years (mean, 6.4 years). At radiotherapy, median age was 70.6 years, median CCI was 2, and median LT-derived LE was 12 years. All variables were statistically significant predictors of overall mortality (all p values
AB - PURPOSE: To test the accuracy of life tables (LTs) in predicting survival in men treated with radiotherapy for localized prostate cancer. METHODS AND MATERIALS: We selected the records of 3,176 patients treated with radiotherapy and who had no clinical evidence of disease relapse. Life table-derived life expectancy (LE) was defined for every individual using a population-specific LT. Age, Charlson Comorbidity Index (CCI), and LT-derived LE were then used as predictors of overall mortality in Cox regression models. Predictive accuracy (PA) was estimated with the Harrell's concordance index and was internally validated with 200 bootstrap resamples. RESULTS: The actuarial median survival was 4.7 years (mean, 6.4 years). At radiotherapy, median age was 70.6 years, median CCI was 2, and median LT-derived LE was 12 years. All variables were statistically significant predictors of overall mortality (all p values
M3 - SCORING: Zeitschriftenaufsatz
VL - 69
SP - 88
EP - 94
JO - INT J RADIAT ONCOL
JF - INT J RADIAT ONCOL
SN - 0360-3016
IS - 1
M1 - 1
ER -