Absence of Malaria-Associated Coagulopathy in Asymptomatic Plasmodium falciparum Infection: Results From a Cross-sectional Study in the Ashanti Region, Ghana
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Absence of Malaria-Associated Coagulopathy in Asymptomatic Plasmodium falciparum Infection: Results From a Cross-sectional Study in the Ashanti Region, Ghana. / Rolling, Christina Charlotte; Phillips, Richard O; Abass, Kabiru Mohammed; Ken Adu Poku, Joseph; Osei-Mireku, Samuel; Osei-Wusu, Bright; Thompson, William; Vinnemeier, Christof D; Huebl, Lena; Langer, Florian; Francke, Paul; Kuta, Piotr; Konrath, Sandra; Renné, Thomas; Tannich, Egbert; Rolling, Thierry; Heinemann, Melina.
in: OPEN FORUM INFECT DI, Jahrgang 10, Nr. 3, 03.2023, S. ofad074.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Absence of Malaria-Associated Coagulopathy in Asymptomatic Plasmodium falciparum Infection: Results From a Cross-sectional Study in the Ashanti Region, Ghana
AU - Rolling, Christina Charlotte
AU - Phillips, Richard O
AU - Abass, Kabiru Mohammed
AU - Ken Adu Poku, Joseph
AU - Osei-Mireku, Samuel
AU - Osei-Wusu, Bright
AU - Thompson, William
AU - Vinnemeier, Christof D
AU - Huebl, Lena
AU - Langer, Florian
AU - Francke, Paul
AU - Kuta, Piotr
AU - Konrath, Sandra
AU - Renné, Thomas
AU - Tannich, Egbert
AU - Rolling, Thierry
AU - Heinemann, Melina
N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2023/3
Y1 - 2023/3
N2 - BACKGROUND: Coagulopathy is common in acute symptomatic Plasmodium falciparum malaria, and the degree of coagulation abnormality correlates with parasitemia and disease severity. Chronic asymptomatic malaria has been associated with increased morbidity. However, the role of coagulation activation in asymptomatic, semi-immune individuals remains unclear. This study investigates the potential effect of asymptomatic P falciparum infection on coagulation activation in semi-immune Ghanaian adults.METHODS: Blood from asymptomatic Ghanaian adults with P falciparum blood stage infection detectable by polymerase chain reaction (PCR) or by both PCR and rapid diagnostic test and from noninfected individuals, was investigated. Markers of coagulation activation including global coagulation tests, D-dimer, antithrombin III, fibrinogen, and von Willebrand factor antigen were tested. Furthermore, blood count, inflammation markers, and liver and kidney function tests were assessed.RESULTS: Acquired coagulopathy was not found in asymptomatic P falciparum infection. Asymptomatic malaria was associated with significantly lower platelet counts. Systemic inflammation markers and liver and kidney function tests were not altered compared to noninfected controls.CONCLUSIONS: There is no laboratory evidence for acquired coagulopathy in adults with asymptomatic P falciparum malaria in highly endemic regions. Lack of laboratory evidence for systemic inflammation and liver and kidney dysfunction indicates that asymptomatic malaria may not be associated with significant morbidity.
AB - BACKGROUND: Coagulopathy is common in acute symptomatic Plasmodium falciparum malaria, and the degree of coagulation abnormality correlates with parasitemia and disease severity. Chronic asymptomatic malaria has been associated with increased morbidity. However, the role of coagulation activation in asymptomatic, semi-immune individuals remains unclear. This study investigates the potential effect of asymptomatic P falciparum infection on coagulation activation in semi-immune Ghanaian adults.METHODS: Blood from asymptomatic Ghanaian adults with P falciparum blood stage infection detectable by polymerase chain reaction (PCR) or by both PCR and rapid diagnostic test and from noninfected individuals, was investigated. Markers of coagulation activation including global coagulation tests, D-dimer, antithrombin III, fibrinogen, and von Willebrand factor antigen were tested. Furthermore, blood count, inflammation markers, and liver and kidney function tests were assessed.RESULTS: Acquired coagulopathy was not found in asymptomatic P falciparum infection. Asymptomatic malaria was associated with significantly lower platelet counts. Systemic inflammation markers and liver and kidney function tests were not altered compared to noninfected controls.CONCLUSIONS: There is no laboratory evidence for acquired coagulopathy in adults with asymptomatic P falciparum malaria in highly endemic regions. Lack of laboratory evidence for systemic inflammation and liver and kidney dysfunction indicates that asymptomatic malaria may not be associated with significant morbidity.
U2 - 10.1093/ofid/ofad074
DO - 10.1093/ofid/ofad074
M3 - SCORING: Journal article
C2 - 36968961
VL - 10
SP - ofad074
JO - OPEN FORUM INFECT DI
JF - OPEN FORUM INFECT DI
SN - 2328-8957
IS - 3
ER -
